Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 293, Issue 3, 2007, Pages

  Scheving, Lawrence A ^a,c   Buchanan, Renee ^a   Krause, Michael A ^a   Zhang, Xiuqi ^a   Stevenson, Mary C ^a   Russell, William E ^a,b,c,d  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Vanderbilt Digestive Disease Research Center   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Cell culture; EGF; Liver; TGF

Indexed keywords

DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOCORTICOID; PROTEIN TYROSINE KINASE;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; IMMUNOLOGY; IMMUNOMODULATION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; DEXAMETHASONE; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOCORTICOIDS; HEPATOCYTES; IMMEDIATE-EARLY PROTEINS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; SIGNAL TRANSDUCTION; SOS1 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 34548753559     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00140.2007     Document Type: Article

References (38)

1. Abramoff MD, Magelhaes PJ, Ram SJ. Image Processing with ImageJ. Biophotonics International 11: 36-42, 2004.
2. Anastasi S, Fiorentino L, Fiorini M, Fraioli R, Sala G, Castellani L, Alema S, Alimandi M, Segatto O. Feedback inhibition by RALT controls signal output by the ErbB network. Oncogene 22: 4221-4234, 2003.
3. Bailly A, Torres-Padilla ME, Tinel AP, Weiss MC. An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors. Nucleic Acids Res 29: 3495-3505, 2001.
4. Bailly-Maitre B, de Sousa G, Zucchini N, Gugenheim J, Boulukos KE, Rahmani R. Spontaneous apoptosis in primary cultures of human and rat hepatocytes: molecular mechanisms and regulation by dexamethasone. Cell Death Differ 9: 945-955, 2002.
5. Baker JB, Barsh GS, Carney DH, Cunningham DD. Dexamethasone modulates binding and action of epidermal growth factor in serum-free cell culture. Proc Natl Acad Sci USA 75: 1882-1886, 1978.
6. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 27: 413-426, 2006.
7. Barnes PJ. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol 148: 245-254, 2006.
8. Carver RS, Mathew PM, Russell WE. Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors. Endocrinology 138: 5195-5201, 1997.
9. Carver RS, Sliwkowski MX, Sitaric S, Russell WE. Insulin regulates heregulin binding and ErbB3 expression in rat hepatocytes. J Biol Chem 271: 13491-13496, 1996.
10. Carver RS, Stevenson MC, Scheving LA, Russell WE. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Gastroenterology 123: 2017-2027, 2002.
11. Chrysis D, Zaman F, Chagin AS, Takigawa M, Savendahl L. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3′-kinase signaling pathway. Endocrinology 146: 1391-1397, 2005.
12. Croxtall JD, Choudhury Q, Flower RJ. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 130: 289-298, 2000.
13. Debonera F, Krasinkas AM, Gelman AE, Aldeguer X, Que X, Shaked A, Olthoff KM. Dexamethasone inhibits early regenerative response of rat liver after cold preservation and transplantation. Hepatology 38: 1563-1572, 2003.
14. Engelbrecht Y, de Wet H, Horsch K, Langeveldt CR, Hough FS, Hulley PA. Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. Endocrinology 144: 412-422, 2003.
15. Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O. Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol Cell Biol 20: 7735-7750, 2000.
16. Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O. Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control. Oncogene 21: 6530-6539, 2002.
17. Giorgino F, Pedrini MT, Matera L, Smith RJ. Specific increase in p85alpha expression in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated phosphatidylinositol 3-kinase activity in cultured muscle cells. J Biol Chem 272: 7455-7463, 1997.
18. Gospodarowicz D, Moran J. Effect of a fibroblast growth factor, insulin, dexamethasone, and serum on the morphology of BALB/c 3T3 cells. Proc Natl Acad Sci USA 71: 4648-4652, 1974.
19. Gospodarowicz D, Moran JS. Stimulation of division of sparse and confluent 3T3 cell populations by a fibroblast growth factor, dexamethasone, and insulin. Proc Natl Acad Sci USA 71: 4584-4588, 1974.
20. Guerriero V Jr, Florini JR. Dexamethasone effects on myoblast proliferation and differentiation. Endocrinology 106: 1198-1202, 1980.
21. Hiragun T, Peng Z, Beaven MA. Dexamethasone up-regulates the inhibitory adaptor protein dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Mol Pharmacol 67: 598-603, 2005.
22. Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 93: 487-490, 1998.
23. Kassel O, Sancono A, Kratzschmar J, Kreft B, Stassen M, Cato AC. Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J 20: 7108-7116, 2001.
24. Loeb JN, Borek C, Yeung LL. Suppression of DNA synthesis in hepatoma cells exposed to glucocorticoid hormone in vitro. Proc Natl Acad Sci USA 70: 3852-3856, 1973.
25. Loyer P, Cariou S, Glaise D, Bilodeau M, Baffet G, Guguen-Guillouzo C. Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro. Evidence of a mitogen restriction point in mid-late G1. J Biol Chem 271: 11484-11492, 1996.
26. McGowan JA. Reciprocal regulation of adult rat hepatocyte growth and functional activities in culture by dimethyl sulfoxide. J Cell Physiol 137: 497-504, 1988.
27. Michalopoulos GK, Bowen WC, Mule K, Luo J. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expr 11: 55-75, 2003.
28. Nagy P, Kiss A, Schnur J, Thorgeirsson SS. Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver. Hepatology 28: 423-429, 1998.
29. Oh HY, Namkoong S, Lee SJ, Por E, Kim CK, Billiar TR, Han JA, Ha KS, Chung HT, Kwon YG, Lee H, Kim YM. Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP. Cell Death Differ 13: 512-523, 2006.
30. Sand TE, Bronstad G, Digernes V, Killi A, Amara W, Refsnes M, Christoffersen T. Quantitative aspects of the effects of insulin, epidermal growth factor and dexamethasone on DNA synthesis in cultured adult rat hepatocytes. Acta Endocrinol 109: 369-377, 1985.
31. Scheving LA, Zhang L, Stevenson MC, Kwak ES, Russell WE. The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling. Am J Physiol Gastrointest Liver Physiol 291: G16-G25, 2006.
32. Singleton JR, Baker BL, Thorburn A. Dexamethasone inhibits insulin-like growth factor signaling and potentiates myoblast apoptosis. Endocrinology 141: 2945-2950, 2000.
33. Talarmin H, Rescan C, Cariou S, Glaise D, Zanninelli G, Bilodeau M, Loyer P, Guguen-Guillouzo C, Baffet G. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol Cell Biol 19: 6003-6011, 1999.
34. Vintermyr OK, Doskeland SO. Characterization of the inhibitory effect of glucocorticoids on the DNA replication of adult rat hepatocytes growing at various cell densities. J Cell Physiol 138: 29-37, 1989.
35. 3H]-thymidine labelling patterns to determine rapid changes in the rate of onset of DNA replication. J Cell Physiol 141: 371-382, 1989.
36. Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR. Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem 281: 39128-39134, 2006.
37. Wang RY, Shen CN, Lin MH, Tosh D, Shih C. Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus. J Virol 79: 13116-13128, 2005.
38. Xu D, Makkinje A, Kyriakis JM. Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. J Biol Chem 280: 2924-2933, 2005.