Is maternal obesity related to semen quality in the male offspring? A pilot study

Human Reproduction

Volumn 22, Issue 10, 2007, Pages 2758-2762

  Ramlau Hansen, C H ^a,b   Nohr, E A ^c   Thulstrup, A M ^a   Bonde, J P ^a   Storgaard, L ^a   Olsen, J ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Body mass index; Prenatal exposure; Reproductive hormones; Semen; Sperm count

Indexed keywords

FOLLITROPIN; HORMONE; INHIBIN B; TESTOSTERONE;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MATERNAL DISEASE; OBESITY; PILOT STUDY; PROGENY; SEMEN ANALYSIS; SPERMATOZOON MOTILITY; STATISTICAL SIGNIFICANCE; UNDERWEIGHT;

EID: 34548745728     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dem219     Document Type: Article

References (30)

1. Diamanti-Kandarakis E, Bergiele A. The influence of obesity on hyperandrogenism and infertility in the female. Obes Rev 2001;2 231-238.
2. Fejes I, Koloszar S, Szollosi J,. Zavaczki Z, Pal A. Is semen quality affected by male body fat distribution? Andrologia 2005;37 155-159.
3. Fejes I, Koloszar S, Zavaczki Z, Daru J, Szollosi J, Pal A. Effect of body weight on testosterone/estradiol ratio in oligozoospermic patients. Arch Androl 2006;52:97-102.
4. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002;288:1723-1727.
5. Gosman GG, Katcher HI, Legro RS. Obesity and the role of gat and adipose hormones in female reproduction. Hum Reprod Update 2006;12 585-601.
6. Hauser R. The environment and male fertility: Recent research on emerging chemicals and semen quality. Semin Reprod Med 2006;24 156-167.
7. Jalkanen L, Tuomilehto J, Tanskanen A, Puska P. Accuracy of self-reported body weight compared to measured body weight. A population survey. Scand J Soc Med 1987;15:191-198.
8. Jaraczewska K, Lulek J, Covaci A, Voorspoels S, Kaluba-Skotarczak A, Drews K, Schepens P. Distribution of polychlorinated biphenyls, organochlorine pesticides and polybrominated diphenyl ethers in human umbilical cord senim, maternal seturn. and milk from Wielkopolska region, Poland. Sci Total Environ 2006;372:20-31.
9. Jensen TK, Andarsson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH, Skakkebaek NE. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004;82:863-870.
10. Jensen TK, Jorgensen N, Asklund C, Carlsen E, Holm M, Skakkebaek NE. Fertility treatment and reproductive health of male offspring: A study of 1,925 young men from the general population. Am J Epidemiol 2007;165:583-590.
11. Jimenez TM, Campoy FC, Canabate RF, Rivas VA, Cerrillo GI, Mariscal AM, Olea-Serrano F. Organochlorine pesticides in serum and adipose tissue of pregnant women in Southern Spain giving birth by cesarean section. Sci Total Environ 2006;372:32-38.
12. Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, Roudebush WE. Impact of body mass index values on sperm quantity and quality. J Androl 2006;27:450-452.
13. Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S. Predictive value of abnormal sperm morphologyin in vitro fertilization. Fertil Steril 1988;49:112-117.
14. Magnusdottir EV, Thorsteinsson T, Thorstainsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 2005;20:208-215.
15. Makler A, Zaidise I, Paldi E, Brandes JM. Factors affecting sperm motility. I. In vitro change in motility with time after ejaculation. Feral Steril 1979;31:147-154.
16. Olsen J, Frische G, Poutsen AO, Kirchheiner H. Changing smoking, drinking, and eating behaviour among pregnant women in Denmark. Evaluation of a health campaign in a local region. Scand J Soc Med 1989;17:277-280.
17. Pettigrew R, Hamilton-Fairley D. Obesity and female reproductive function. Br Med Bull 1997;53:341-358.
18. Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sorensen TI, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod 2007a; 22:1634-1637.
19. Ramlau-Hansen CH, Thulstrup AM, Storgaard L, Toft G, Olsen J, Bonde JP. Is prenatal exposure to tobacco smoking a cause of poor semen quality? A follow-up study. Am J Epidemiol 2007b;165:1372-1379.
20. Ramlau-Hansen CH, Thulstrup AM, Bonde JP, Ernst E. Is self-measuring of testicular volume by a Prader orchidometer a valid method? Fertil Steril 2007c;87:1480-1482.
21. Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD. Reduced fertility among overweight and obese men. Epidemiology 2006;17:520-523.
22. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993;341:1392-1395.
23. Silventoinen K, Sans S, Tolonen H, Monterde D, Kuulasmaa K, Kesteloot H, Tuomilehto J. Trends in obesity and energy supply in the WHO MONICA Project. Int J Obes Relat Metab Disord 2004;28:710-718.
24. Storgaard L, Bonde JP, Ernst E, Andersen CY, Kyvik KO. Olsen J. Effect of prenatal exposure to oestrogen on quality of semen: Comparison of twins and singleton brothers. BMJ 2002;325:252-253.
25. Storgaard L, Bonde JP, Olsen J. Male reproductive disorders in humans and prenatal indicators of estrogen exposure. A review of published epidemiological studies. Reprod Toxicol 2006;21:4-15.
26. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: An analysis of 101 studies published 1934-1996. Environ Health Perspect 2000;108:961-966.
27. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 2005;113:1056-1061.
28. Toft,G. Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A, Lindh CH, Pedersen HS, Ludwicki JK, Lesovoy V, Hagmar L et al. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 2006;17:450-458.
29. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th edn. Cambridge. Cambridge University Press, 1999.
30. World Health Organization. Obesity: Preventing and Managing the Global Epidemic. 2000.