Effect of anti-HER-2 engineered antibody chA21 on MMP-2 and TIMP-2 expression of human ovarian cancer SKOV3 cells

Journal of Xi'an Jiaotong University (Medical Sciences)

Volumn 28, Issue 4, 2007, Pages

  Gao, Yi ^a   Wu, Qiang ^a   Ling, Xiaoguang ^a   Cheng, Liansheng ^b   Liu, Jing ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

chA21; Engineering antibody; HER 2; MMP 2; Ovarian cancer; TIMP 2

Indexed keywords

ANTIBODY CHA21; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; GELATINASE A; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY ENGINEERING; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE NEU; OVARY CANCER; PROTEIN EXPRESSION;

EID: 34548737573     PISSN: 16718259     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Verri E, Guglielmini P, Puntoni M, et al. HER2/neu oncoprotein overexpression in epithelial ovarian cancer, evaluation of its prevalence and prognostic significance [J]. Clinical study, 2005, 68(2-3):154-161.
2. Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/ neu proto-oncogene in human breast and ovarian cancer [J]. Science, 1989, 244(4905):707-712.
3. Sanderson MP, Dempsey PJ, Dunbar AJ. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors [J]. Growth Factors, 2006, 24(2), 121-136.
4. Chinese source
5. Chinese source
6. Chinese source
7. Kamat AA, Fletcher M, Gruman LM, et al. The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer [J]. Clin Cancer Res, 2006, 12(6):1707-1714.
8. Sakata K, Shigemasa K, Nagai N, et al. Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial of the ovary [J]. Int J Oncol, 2000, 17(4):673-681.
9. Michel RB, Andrews PM, Castillo ME, et al. In vitro cytotoxicity of carcinoma cells with 111In-labeled antibodies to HER-2 [J]. Mol Cancer Ther, 2005, 4(6):927-937.
10. Chinese source
11. Yosef Y, Mark XS. Untangling the ErbB signaling network [J]. Nature Rev, 2001, 2(2):127-137.
12. Ke Z, Lin H, Fan Z, et al. MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB-2 [J]. Int J Cancer, 2006, 119(1):8-16.
13. Hsu MC, Chang HC, Hung WC. HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion [J]. J Biol Chem, 2006, 281(8):4718-4725.
14. La Rocca G, Pucci-Minafra I, Marrazzo A, et al. Zymographic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera [J]. Br J Cancer, 2004, 90(7):1414-1421.