Inhibitory effects of an aqueous extract of Gynura procumbens on human mesangial cell proliferation

Korean Journal of Physiology and Pharmacology

Volumn 11, Issue 4, 2007, Pages 145-148

  Lee, Hee Jae ^a   Lee, Byung Cheol ^b   Chung, Joo Ho ^c   Wiryowidagdo, Sumali ^d   Chun, Wanjoo ^a   Kim, Sung Soo ^a   Kim, Hyunsook ^a   Choe, Myeon ^a  

^a Kangwon National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

^d UNIVERSITY OF INDONESIA   (Indonesia)

Author keywords

Gynura procumbens (Lour.) Merr.; Mesangial cell; Proliferation; Renal disease

Indexed keywords

CAPTOPRIL; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; DNA; GYNURA PROCUMBENS EXTRACT; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; GLOMERULOPATHY; HUMAN; HUMAN CELL; KIDNEY DISEASE; MESANGIUM CELL; PROTEIN EXPRESSION;

EID: 34548737196     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 346: 371-374, 1990
2. Brooks DP, Short BG, Cyronak MJ, Contino LC, DiCristo M, Wang YX, Ruffolo RR. Comparison between carvedilol and captopril in rats with partial ablation-induced chronic renal failure. Br J Pharmacol 109: 581-586, 1993
3. Floege J, Johnson RJ. Multiple roles for platelet-derived growth factor in renal disease. Miner Electrolyte Metab 21: 27-82, 1995
4. Floege J, Ostendorf T, Janssen U, Burg M, Radeke HH, Vargeese C, Gill SC, Green LS, Janji N. Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol 154: 169-179, 1999
5. Grandaliano G, Ranieri E, Monno R, Gesualdo L, Schena F. Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol 7: 229-235, 1999
6. Iskander MN, Song Y, Coupar IM, Jiratchariyakul W. Antiinflammatory screening of the medicinal plant Gynura procumbens. Plant Foods Hum Nutr 57: 234-244, 2002
7. Kim M, Lee HJ, Wiryowidagdo S, Kim HK. Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats. J Med Food 9: 587-590, 2006
8. Kurogi Y. Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease. Med Res Rev 23: 15-31, 2003
9. Marshall CB, Shankland SJ. Cell cycle and glomerular disease: a minireview. Nephron Exp Nephrol 102: 39-48, 2006
10. Perry LM, Medicinal. Plants of East and Southeast Asia: Attributed Properties and Uses. The MIT Press, England, p 94-95, 1980
11. Praga M, Hernandez E, Montoyo C, Andres A, Ruilope LM, Rodicio JL. Long-term beneficial effects of angiotensin-converting enzyme inhibition in patients with nephrotic proteinuria. Am J Kidney Dis 20: 240-248, 1992
12. Shankland SJ, Hugo C, Coats SR, Nangaku M, Pichler RH, Gordon KL, Pippin J, Roberts JM, Couser WG, Johnson RJ. Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis. Kidney Int 50: 1230-1239, 1996
13. Shankland SJ, Johnson RJ. TGF-β in glomerular disease. Miner Electrolyte Metab 24: 168-173, 1995
14. Terada Y, Yamada T, Nakashima O, Sasaki S, Nonoguchi H, Tomita K, Marumo F. Expression of PDGF and PDGF receptor mRNA in glomeruli in IgA nephropathy. J Am Soc Nephrol 8: 817-819, 1997
15. Wang ZQ, Liang KH, Pahl MV, Vaziri ND. Effect of heparin on mesangial cell growth and gene expression of matrix proteins. Nephrol Dial Transplant 13: 3052-3057, 1998
16. Yokozawa T, Oura H, Hattori M, Iwano M, Dohi K. Effects of Wen-Pi-Tang and its crude drug extracts on proliferation of cultured mouse mesangial cells. Phytother Res 8: 170-173, 1994
17. Zhang XF, Tan BK. Effects of an ethanolic extract of Gynura procumbens on serum glucose, cholesterol and triglyceride levels in normal and streptozotocin-induced diabetic rats. Singapore Med J 41: 9-13, 2000