Discovery and characterization of a novel splice variant of the GM-CSF receptor α subunit

Experimental Hematology

Volumn 35, Issue 10, 2007, Pages 1483-1494

  Pelley, Jennifer L ^a   Nicholls, Chris D ^a   Beattie, Tara L ^a   Brown, Christopher B ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR ALPHA; RECEPTOR SUBUNIT; REPETITIVE DNA; UNCLASSIFIED DRUG;

ALU SEQUENCE; AMINO ACID SEQUENCE; ARTICLE; CELL SURFACE; COLONY FORMING UNIT GM; CONTROLLED STUDY; DNA SPLICING; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; PROTEIN VARIANT; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

ALTERNATIVE SPLICING; ALU ELEMENTS; AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; EXONS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LIGANDS; MICE; MUTAGENESIS, INSERTIONAL; NEUTROPHILS; NIH 3T3 CELLS; PEPTIDE HYDROLASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE;

EID: 34548701996     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.06.008     Document Type: Article

References (41)

1. Emanuel P.D. Juvenile myelomonocytic leukemia. Curr Hematol Rep 3 (2004) 203-209
2. Kitamura T., Tanaka N., Watanabe J., et al. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J Exp Med 190 (1999) 875-880
3. Venkateshiah S.B., Thomassen M.J., and Kavuru M.S. Pulmonary alveolar proteinosis. Clinical manifestations and optimal treatment strategies. Treat Respir Med 3 (2004) 217-227
4. Korzenik J.R., Dieckgraefe B.K., Valentine J.F., Hausman D.F., and Gilbert M.J. Sargramostim for active Crohn's disease. N Engl J Med 352 (2005) 2193-2201
5. Gearing D.P., King J.A., Gough N.M., and Nicola N.A. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J 8 (1989) 3667-3676
6. Gasson J.C., Kaufman S.E., Weisbart R.H., Tomonaga M., and Golde D.W. High-affinity binding of granulocyte-macrophage colony-stimulating factor to normal and leukemic human myeloid cells. Proc Natl Acad Sci USA 83 (1986) 669-673
7. Park L.S., Friend D., Gillis S., and Urdal D.L. Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. J Exp Med 164 (1986) 251-262
8. DiPersio J., Billing P., Kaufman S., Eghtesady P., Williams R.E., and Gasson J.C. Characterization of the human granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem 263 (1988) 1834-1841
9. Bussolino F., Wang J.M., Defilippi P., et al. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 337 (1989) 471-473
10. Raines M.A., Liu L., Quan S.G., Joe V., DiPersio J.F., and Golde D.W. Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. Proc Natl Acad Sci USA 88 (1991) 8203-8207
11. Williams W.V., VonFeldt J.M., Rosenbaum H., Ugen K.E., and Weiner D.B. Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution. Arthritis Rheum 37 (1994) 1468-1478
12. Brown C.B., Beaudry P., Laing T.D., Shoemaker S., and Kaushansky K. In vitro characterization of the human recombinant soluble granulocyte-macrophage colony-stimulating factor receptor. Blood 85 (1995) 1488-1495
13. Prevost J.M., Pelley J.L., Zhu W., et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory stimuli up-regulate secretion of the soluble GM-CSF receptor in human monocytes: evidence for ectodomain shedding of the cell surface GM-CSF receptor alpha subunit. J Immunol 169 (2002) 5679-5688
14. Ashworth A., and Kraft A. Cloning of a potentially soluble receptor for human GM-CSF. Nucleic Acids Res 18 (1990) 7178
15. Nakagawa Y., Kosugi H., Miyajima A., Arai K., and Yokota T. Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. J Biol Chem 269 (1994) 10905-10912
16. Sayani F., Montero-Julian F.A., Ranchin V., et al. Identification of the soluble granulocyte-macrophage colony stimulating factor receptor protein in vivo. Blood 95 (2000) 461-469
17. Pruitt K.D., Tatusova T., and Maglott D.R. NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res 33 (2005) D501-D504
18. Maglott D., Ostell J., Pruitt K.D., and Tatusova T. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 33 (2005) D54-D58
19. Altschul S.F., Gish W., Miller W., Myers E.W., and Lipman D.J. Basic local alignment search tool. J Mol Biol 215 (1990) 403-410
20. Jurka J., and Milosavljevic A. Reconstruction and analysis of human Alu genes. J Mol Evol 32 (1991) 105-121
21. Sorek R., Ast G., and Graur D. Alu-containing exons are alternatively spliced. Genome Res 12 (2002) 1060-1067
22. Kreahling J., and Graveley B.R. The origins and implications of Aluternative splicing. Trends Genet 20 (2004) 1-4
23. Lev-Maor G., Sorek R., Shomron N., and Ast G. The birth of an alternatively spliced exon: 3′ splice-site selection in Alu exons. Science 300 (2003) 1288-1291
24. Alberts B, Bray D, Lewis J, Raff M., Roberts K, and J.D. Watson. Molecular Biology of the Cell. 3rd ed. New York: Garland Publishing, Inc.; 1994.
25. Wognum A.W., Westerman Y., Visser T.P., and Wagemaker G. Distribution of receptors for granulocyte-macrophage colony-stimulating factor on immature CD34+ bone marrow cells, differentiating monomyeloid progenitors, and mature blood cell subsets. Blood 84 (1994) 764-774
26. Yamada T., Sun Q., Zeibecoglou K., et al. IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor alpha-subunit, and common beta-subunit expression by peripheral leukocytes and blood dendritic cells. J Allergy Clin Immunol 101 (1998) 677-682
27. Heaney M.L., Vera J.C., Raines M.A., and Golde D.W. Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor alpha subunits are independently regulated in HL-60 cells. Proc Natl Acad Sci USA 92 (1995) 2365-2369
28. Carryn S., Van de Velde S., Van Bambeke F., Mingeot-Leclercq M.P., and Tulkens P.M. Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide. J Infect Dis 189 (2004) 2101-2109
29. Crosier K.E., Hall L.R., Vitas M.R., and Crosier P.S. Expression and functional analysis of two isoforms of the human GM-CSF receptor alpha chain in myeloid development and leukaemia. Br J Haematol 98 (1997) 540-548
30. Lotem J., and Sachs L. Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc Natl Acad Sci USA 76 (1979) 5158-5162
31. Collins S.J., Ruscetti F.W., Gallagher R.E., and Gallo R.C. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci USA 75 (1978) 2458-2462
32. Koeffler H.P., Amatruda T., Ikekawa N., Kobayashi Y., and DeLuca H.F. Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues. Cancer Res 44 (1984) 5624-5628
33. Prevost J.M., Farrell P.J., Iatrou K., and Brown C.B. Determinants of the functional interaction between the soluble GM-CSF receptor and the GM-CSF receptor beta-subunit. Cytokine 12 (2000) 187-197
34. Sorek R., Lev-Maor G., Reznik M., et al. Minimal conditions for exonization of intronic sequences: 5′ splice site formation in alu exons. Mol Cell 14 (2004) 221-231
35. Crosier K.E., Wong G.G., Mathey-Prevot B., Nathan D.G., and Sieff C.A. A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. Proc Natl Acad Sci USA 88 (1991) 7744-7748
36. Hu X., Emanuel P.D., and Zuckerman K.S. Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor. Biochim Biophys Acta 1223 (1994) 306-308
37. Hu X., and Zuckerman K.S. Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein. Am J Hematol 58 (1998) 145-147
38. Lavictoire S.J., Parolin D.A., Klimowicz A.C., Kelly J.F., and Lorimer I.A. Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem 278 (2003) 5292-5299
39. Black R.A., Doedens J.R., Mahimkar R., et al. Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity. Biochem Soc Symp 70 (2003) 39-52
40. Vandenbark G.R., deCastro C.M., Taylor H., Dew-Knight S., and Kaufman R.E. Cloning and structural analysis of the human c-kit gene. Oncogene 7 (1992) 1259-1266
41. Wypych J., Bennett L.G., Schwartz M.G., et al. Soluble kit receptor in human serum. Blood 85 (1995) 66-73