Recombinant human luteinizing hormone, lutropin alfa, for the induction of follicular development and pregnancy in profoundly gonadotrophin-deficient women

Clinical Endocrinology

Volumn 67, Issue 4, 2007, Pages 563-569

  Kaufmann, Robert ^a   Dunn, Randall ^b   Vaughn, Thomas ^c   Hughes, Graeme ^d   O'Brien, Fanny ^e   Hemsey, George ^e   Thomson, Barbara ^e   St L O'Dea, Louis ^e  

^a Southeastern Fertility Center   (United States)

^b Obstetrical and Gynecological Associates   (United States)

^c Texas Fertility Center   (United States)

^d PRINCE OF WALES PRIVATE HOSPITAL   (Australia)

^e EMD SERONO INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; GONADOTROPIN; LUTROPIN ALFA; PLACEBO; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GONADOTROPHIN DEFICIENCY; HEALTH CENTER; HORMONE DEFICIENCY; HOSPITALIZATION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; MEDICAL PRACTICE; MULTIPLE CYCLE TREATMENT; OVARY DEVELOPMENT; OVARY FOLLICLE CELL; OVARY HYPERSTIMULATION; OVULATION; PREGNANCY OUTCOME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ESTRADIOL; FEMALE; FERTILITY AGENTS, FEMALE; FOLLICLE STIMULATING HORMONE; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; GONADOTROPINS; HUMANS; HYPOGONADISM; INFERTILITY, FEMALE; LUTEINIZING HORMONE; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; SAFETY;

EID: 34548698186     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.02925.x     Document Type: Article

References (30)

1. Jones, J.R. Kemmann, E. (1976) Olfacto-genital dysplasia in the female. Obstetrics and Gynecology, 5, 443 446.
2. O'Dea, L. Lee, P.A. (2001) Delayed puberty. In : J.S. Sanfilippo, D. Muram, J. Dewhurst, P.A. Lee eds. Pediatric and Adolescent Gynecology. W.B. Saunders, Philadelphia, 72 86.
3. Schoot, D.C., Coelingh, B., Mannaerts, B., Lamberts, S.W.J., Bouchard, P. Fauser, B.C.J.M. (1992) Human recombinant follicle-stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency. Journal of Clinical Endocrinology and Metabolism, 74, 1471 1473.
4. Schoot, D.C., Harlin, J., Shoham, Z., Mannaerts, B.M.J.L., Lahlou, N., Bouchard, P., Bennink, H. Fauser, B.C. (1994) Recombinant human follicle-stimulating hormone and ovarian response in gonadotrophin-deficient women. Human Reproduction, 9, 1237 1242.
5. Couzinet, B., Lestrat, N., Brailly, S., Forest, M. Schaison, G. (1988) Stimulation of ovarian follicular maturation with pure follicle-stimulating hormone in women with gonadotropin deficiency. Journal of Clinical Endocrinology and Metabolism, 66, 552 556.
6. Crowley, W.F. Jr. & McArthur, J.W. (1980) Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH). Journal of Clinical Endocrinology and Metabolism, 51, 173 175.
7. Shoham, Z., Mannaerts, B., Insler, V. Coelingh, B. (1993) Induction of follicular growth using recombinant human follicle stimulating hormone in two volunteer women with hypogonadotrophic hypogonadism. Fertility and Sterility, 59, 738 742.
8. Balasch, J., Miro, F., Burzaco, I., Casamitjana, R., Civico, S., Ballesca, J.L., Puerto, B. Vanrell, J.A. (1995) The role of luteinizing hormone in human follicle development and oocyte fertility. Evidence from in-vitro fertilization in a woman with long-standing hypogonadotrophic hypogonadism and using recombinant human follicle stimulating hormone. Human Reproduction, 10, 1678 1683.
9. European Recombinant Human LH Study Group 1998) Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH- and FSH-deficient anovulatory women: a dose-finding study. Journal of Clinical Endocrinology and Metabolism, 83, 1507 1514.
10. Seibel, M.M. (1990) Ovulation induction: FSH. In : M.M. Seibel ed. Infertility: A Comprehensive Text. Appleton & Lange, 323 332.
11. Overton, C.E., Davis, C.J., West, C., Davies, M.C. Conway, G.S. (2002) High risk pregnancies in hypopituitary women. Human Reproduction, 17, 1464 1467.
12. Shoham, Z., Balen, A.H., Patel, A. Jacobs, H.S. (1991) Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients. Fertility and Sterility, 56, 1048 1053.
13. O'Dea, L. the US Recombinant Human LH Study Group 2000) Recombinant LH in support of recombinant FSH in female hypogonadotropic hypogonadism - evidence of threshold effect. Fertility and Sterility, 74 (3 Suppl. 1 S36.
14. Silverberg, K.M., Olive, D.L., Burns, W.N., Johnson, J.V., Groff, T.R. Schenken, R.S. (1991) Follicular size at the time of human chorionic gonadotropin administration predicts ovulation outcome in human menopausal gonadotropin-stimulated cycles. Fertility and Sterility, 56, 296 300.
15. Key, T.J.A. Pike, M.C. (1988) The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate. Its central role in explaining and predicting endometrial cancer risk. British Journal of Cancer, 57, 205 212.
16. Schwartz, M., Jewelewicz, R., Dyrenfurth, I., Tropper, P. Van de Wiele, R.L. (1980) The use of human menopausal and chorionic gonadotropins for induction of ovulation. American Journal of Obstetrics and Gynecology, 138 (7 Part 1 801 807.
17. Mishell, D.R. Jr., Nakamura, R.M., Crosignani, P.G., Stone, S., Kharma, K., Nagata, Y. Thorneycroft, I.H. (1971) Serum gonadotropin and steroid patterns during the normal menstrual cycle. American Journal of Obstetrics and Gynecology, 11, 60 65.
18. Siklosi, G., Siklos, P., Hintalan, A., Olajos, F. Marcsek, Z. (1984) Episodic secretion of hormones and the diagnostic value of single blood estimates II. Progesterone, oestradiol and oestrone. Acta Medica Hungarica, 41, 203 211.
19. Vermesh, M. Kletzky, O.A. (1987) Longitudinal evaluation of the luteal phase and its transition into the follicular phase. Journal of Clinical Endocrinology and Metabolism, 65, 653 658.
20. Abraham, G.E., Odell, W.D., Swerdloff, R.S. Hopper, K. (1972) Simultaneous radioimmunoassay of plasma FSH, LH, progesterone, 17-hydroxyprogesterone, and estradiol-17b during the menstrual cycle. Journal of Clinical Endocrinology and Metabolism, 34, 312 318.
21. Ross, G.T., Cargille, C.M., Lipsett, M.B., Rayford, P.L., Marshall, J.R., Strott, C.A. Rodbard, D. (1970) Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles. Recent Progress in Hormone Research, 26, 1 62.
22. Van de Wiele, R.L. Dyrenfurth, I. (1973) Gonadotrophin-steroid interrelationships. Pharmacological Reviews, 25, 189 207.
23. Dodson, K.S., Coutts, J.R.T. Macnaughton, M.C. (1975) Plasma sex steroid and gonadotrophin patterns in human menstrual cycles. British Journal of Obstetrics and Gynaecology, 82, 602 614.
24. Haning, R.V. Jr., Levin, R.M., Behrman, H.R., Kase, N.G. Speroff, L. (1979) Plasma estradiol window and urinary estriol glucuronide determinations for monitoring menotropin induction of ovulation. Obstetrics and Gynecology, 54, 442 447.
25. Practice Committee (2003) Induction of ovarian follicle development and ovulation with exogenous gonadotrophins. American Society of Reproductive Medicine, 23, 7 0003.
26. Oelsner, G., Serr, D.M., Mashiach, S., Blankstein, J., Snyder, M. Lunenfeld, B. (1978) The study of induction of ovulation with menotropins: analysis of results of 1897 treatment cycles. Fertility and Sterility, 30, 538 544.
27. Schenker, J.G., Yarkoni, S. Granat, M. (1981) Multiple pregnancies following induction of ovulation. Fertility and Sterility, 35, 105 123.
28. Thompson, C.R. Hansen, L.M. (1970) Pergonal (menotropins): a summary of clinical experience in the induction of ovulation and pregnancy. Fertility and Sterility, 21, 844 853.
29. Shapiro, H., Cowell, C. Casper, R.F. (1993) The use of vaginal ultrasound for monitoring endometrial preparation in a donor oocyte program. Fertility and Sterility, 59, 1055 1058.
30. Adams, J.M., Tan, S.L., Wheeler, M.J., Morris, D.V., Jacobs, H.S. Franks, S. (1988) Uterine growth in the follicular phase of spontaneous ovulatory cycles and during luteinizing hormone-releasing hormone-induced cycles in women with normal or polycystic ovaries. Fertility and Sterility, 49, 52 55.