Structure-Based Engineering of Strictosidine Synthase: Auxiliary for Alkaloid Libraries

Chemistry and Biology

Volumn 14, Issue 9, 2007, Pages 979-985

  Loris, Elke A ^a   Panjikar, Santosh ^b   Ruppert, Martin ^a   Barleben, Leif ^a   Unger, Matthias ^c   Schübel, Helmut ^d   Stöckigt, Joachim ^a,e  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d Hermes Arzneimittel GmbH   (Germany)

^e ZHEJIANG UNIVERSITY   (China)

Author keywords

CHEMBIOL; MICROBIO

Indexed keywords

INDOLE ALKALOID; LYASE; STRICTOSIDINE; STRICTOSIDINE SYNTHETASE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; VINCA ALKALOID;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG SCREENING; ENZYME SPECIFICITY; GENETICS; METHODOLOGY; MISSENSE MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

CARBON-NITROGEN LYASES; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; INDOLE ALKALOIDS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PLANT PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY; VINCA ALKALOIDS;

CATHARANTHUS; EMBRYOPHYTA; RAUVOLFIA SERPENTINA;

EID: 34548694786     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2007.08.009     Document Type: Article

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