Synthesis of γ-hydroxybutenolides applying crossed aldol condensation in the presence of a bulky Lewis acid and their anti-tumor activity

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 9, 2007, Pages 1365-1370

  Yamano, Yumiko ^a   Fujita, Yumi ^a   Mizuguchi, Yukari ^a   Nakagawa, Kimie ^a   Okano, Toshio ^a   Ito, Masayoshi ^a   Wada, Akimori ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

hydroxybutenolide; Anti tumor activity; Bulky lewis acid; Crossed aldol condensation

Indexed keywords

4 [6 (2 BENZO[B]THIENYL)HEXA 1,3,5 TRIENYL] 5 HYDROXY 2(5H) FURANONE; 4 [6 (2 BENZO[B]THIENYL)HEXA 1,3,5 TRIENYL] 5 TERT BUTYL DIMETHYLSILYLOXY 2(5H) FURANONE; 4 [6 (2 BENZOFURANYL)HEXA 1,3,5 TRIENYL] 5 HYDROXY 2(5H) FURANONE; 4 [6 (2 BENZOFURANYL)HEXA 1,3,5 TRIENYL] 5 TERT BUTYL DIMETHYLSILYLOXY 2(5H) FURANONE; 4 [6 (2 FURANYL)HEXA 1,3,5 TRIENYL] 5 HYDROXY 2(5H) FURANONE; 5 HYDROXY 4 (2 PHENYLETHENYL) 2 FURANONE; 5 HYDROXY 4 (4 PHENYLBUTA 1,3 DIENYL) 2(5H) FURANONE; 5 HYDROXY 4 (6 PHENYLHEXA 1,3,5 TRIENYL) 2(5H) FURANONE; 5 HYDROXY 4 (8 PHENYLOCTA 1,3,5,7 TETRAENYL) 2(5H) FURANONE; 5 HYDROXY 4 [6 (2 THIENYL)HEXA 1,3,5 TRIENYL] 2(5H) FURANONE; 5 TERT BUTYLDIMETHYLSILYLOXY 4 (6 PHENYLHEXA 1,3,5 TRIENYL) 2(5H) FURANONE; 5 TERT BUTYLDIMETHYLSILYLOXY 4 (8 PHENYLOCTA 1,3,5,7 TETRAENYL) 2(5H) FURANONE; 5 TERT BUTYLDIMETHYLSILYLOXY 4 [6 (2 FURANYL)HEXA 1,3,5 TRIENYL] 2(5H) FURANONE; 5 TERT BUTYLDIMETHYLSILYLOXY 4 [6 (2 THIENYL)HEXA 1,3,5 TRIENYL] 2(5H) FURANONE; ALDEHYDE DERIVATIVE; ALUMINUM DERIVATIVE; ALUMINUM TRIS(2,6 DIPHENYLPHENOXIDE); ANTINEOPLASTIC AGENT; BUTENOLIDE; GAMMA HYDROXYBUTENOLIDE DERIVATIVE; LEWIS ACID; UNCLASSIFIED DRUG;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FLOW CYTOMETRY; HORNER WADSWORTH EMMONS REACTION; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

ALDEHYDES; ANTIGENS, CD11B; ANTIGENS, CD14; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; SODIUM OXYBATE; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; THYMIDINE;

EID: 34548692509     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.1365     Document Type: Article

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