Exercise and hypoxia: The role of the autonomic nervous system

Respiratory Physiology and Neurobiology

Volumn 158, Issue 2-3, 2007, Pages 280-286

  Favret, Fabrice ^a   Richalet, Jean Paul ^a  

^a UNIVERSITÉ PARIS 13   (France)

Author keywords

Altitude; Autonomic nervous system beta adrenoceptors; Downregulation; Exercise; Muscarinic receptors

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MUSCARINIC RECEPTOR; OXYGEN; VASCULOTROPIN;

ARTERIAL OXYGEN SATURATION; ARTICLE; AUTONOMIC NERVOUS SYSTEM; DESENSITIZATION; EXERCISE; HEART OUTPUT; HEART RATE; HUMAN; HYPOXIA; LUNG GAS EXCHANGE; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRAINING;

ACCLIMATIZATION; ALTITUDE; ANIMALS; ANOXIA; AUTONOMIC NERVOUS SYSTEM; EXERCISE; HUMANS; OXYGEN; OXYGEN CONSUMPTION;

EID: 34548691066     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.04.001     Document Type: Article

References (67)

1. Abdelmalki A., Fimbel S., Mayet-Sornay M.H., Sempore B., and Favier R. Aerobic capacity and skeletal muscle properties of normoxic and hypoxic rats in response to training. Pflügers Arch. 431 (1996) 671-679
2. Antezana A.-M., Kacimi R., Le Trong J.-L., Marchal M., Abousahl I., Dubray C., and Richalet J.-P. Adrenergic status of humans during prolonged exposure to the altitude of 6542 m. J. Appl. Physiol. 76 (1994) 1055-1059
3. Bender P.R., Groves B.M., Mc Cullough E.E., Mc Cullough R.G., Huang S.Y., Hamilton A.J., Wagner P.D., Cymerman A., and Reeves J.T. Oxygen transport to exercising leg in chronic hypoxia. J. Appl. Physiol. 65 (1988) 2592-2597
4. Bigard A.X., Brunet A., Guezennec C.Y., and Monod H. Effects of chronic hypoxia and endurance training on muscle capillarity in rats. Pflügers Arch. 419 (1991) 225-229
5. Bogaard H.J., Hopkins S.R., Yamaya Y., Niizeki K., Ziegler M.G., and Wagner P.D. Role of the autonomic nervous system in the reduced maximal cardiac output at altitude. J. Appl. Physiol. 93 (2002) 271-279
6. Boushel R., Calbet J.A.L., Rådegran G., Sondegaard H., Wager P.D., and Saltin B. Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation 104 (2001) 1781-1785
7. Boussuges A., Molenat F., Burnet H., Cauchy E., Gardette B., Sainty J.-M., Jammes Y., and Richalet J.-P. Operation Everest III (COMEX'97): modifications of cardiac function secondary to altitude-induced hypoxia: an echocardiographic and Doppler study. Am. J. Resp. Crit. Care Med. 161 (2000) 264-270
8. O2 max and cardiovascular function in lowlanders acclimatised to 5260 m. J. Physiol. 545 (2004) 715-728
9. Cerretelli P. Limiting factors to oxygen transport on Mt. Everest. J. Appl. Physiol. 40 (1976) 607-610
10. Cerretelli P. Energy sources for muscular exercise. Int. J. Spots med. 13 (1992) S106-S110
11. Christensen E.H., and Forbes W.H. Der Kreislauf in grossen Höhen. Arch. Physiol. 76 (1937) 75-89
12. Clancy R.L., Moue Y., Erwig L.P., Smith P.G., and Gonzalez N.C. Role of beta-adrenergic and cholinergic systems in acclimatisation to hypoxia in the rat. Respir. Physiol. 107 (1997) 75-84
13. Deveci D., Marshall J.M., and Egginton S. Chronic hypoxia induces prolonged angiogenesis in skeletal muscles of rat. Exp. Physiol. 87 3 (2002) 287-291
14. di Prampero P.E., and Ferretti G. Factors limiting maximal oxygen consumption in humans. Respir. Physiol. 80 (1990) 113-127
15. Eguzkitza J., and Iturriza A. De qué mueren los ochomilistas?. In: Botella J., Espacio A., and Ferrer V. (Eds). Nuevos Progresos en Medicina de Montana (2006), Sociedad Española de Medicina y Auxilio en Montaña 15-28
16. Favret F., Henderson K.K., Allen J., Richalet J.P., and Gonzalez N.C. Exercise training improves lung gas exchange, attenuates acute hypoxic pulmonary hypertension, but does not prevent pulmonary hypertension of prolonged hypoxia. J. Appl. Physiol. 100 (2006) 20-25
17. 2 transport during maximal exercise. J. Appl. Physiol. 95 (2003) 1531-1541
18. 2 transport in exercise. Am. J. Physiol. 280 (2001) R730-R738
19. Gaussin V., Tomlinson J.E., Depre C., Engelhardt S., Antos C.L., Takagi G., Hein L., Topper J.N., Liggett S.B., Olson E.N., Lohse M.J., Vatner S.F., and Vatner D.E. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation 108 (2003) 2926-2933
20. 2 uptake in rats acclimatized to simulated altitude. J. Appl. Physiol. 84 (1998) 164-168
21. Gonzalez N.C., Clancy R.L., and Wagner P.D. Determinants of maximal oxygen yuptake in rats acclimated to simulated altitude. J. Appl. Physiol. 75 (1993) 1608-1614
22. Gonzalez N.C., Sokari A., and Clancy R.L. Maximum oxygen uptake and arterial blood oxygenation during hypoxic exercise in rats. J. Appl. Physiol. 71 (1991) 1041-1049
23. Grover R.F., Weil J.V., and Reeves J.T. Cardiovascular adaptations to exercise at high altitude. Exerc. Sport Sci. Rev. 14 (1986) 269-302
24. Hartley L.H., Vogel J.A., and Cruz J.C. Reduction of maximal exercise heart rate at altitude and its reversal with atropine. J. Appl. Physiol. 36 (1974) 362-365
25. O2 max) more than living and training in normoxia. J. Appl. Physiol. 90 (2001) 2057-2062
26. Hoppeler H., and Vogt M. Muscle tissue adaptations to hypoxia. J. Exp. Biol. 204 (2001) 3133-3139
27. Hrbasova M., Novotny J., Hejnova L., Kolar F., Neckar J., and Svoboda P. Altered myocardial Gs protein and adenylyl cyclase signaling in rats exposed to chronic hypoxia and normoxic recovery. J. Appl. Physiol. 94 (2002) 2423-2432
28. Kacimi R., Richalet J.P., and Crozatier B. Hypoxia-induced differential modulation of adenosinergic and muscarinic receptors in rat heart. J. Appl. Physiol. 75 (1993) 1123-1128
29. Kacimi R., Richalet J.P., Corsin A., Abousahl I., and Crozatier B. Hypoxia-induced downregulation of β-adrenergic receptors in rat heart. J. Appl. Physiol. 73 (1992) 1377-1382
30. Kacimi R., Moalic J.M., Aldashev A., Vatner D.E., Richalet J.-P., and Crozatier B. Differential regulation of G-protein expression in rat hearts exposed to chronic hypoxia. Am. J. Physiol. Heart Circ. Physiol. 38 (1995) H1865-H1873
31. Kaijser L., Grubbstrom J., and Berglund B. Coronary circulation in acute hypoxia. Clin. Physiol. 10 (1990) 259-263
32. LaManna J.C., Chavez J.C., and Pichiule P. Structural and functional adaptation to hypoxia in the rat brain. J. Exp. Biol. 207 (2004) 3163-3169
33. Levine B.D., Stray-Gundersen J., Duhaime G., Snell P.G., and Friedman D.B. Living high-training low: the effect of altitude acclimatisation/normoxic training in trained runners. Med. Sci. Sports Exerc. 23 (1991) 25 (Abstract)
34. León-Velarde F., Bourin M.C., Germack R., Mohammidi K., Crozatier B., and Richalet J.P. Differential alterations in cardiac adrenergic signalling in chronic hypoxia or norepinephrine infusion. Am. J. Physiol. 280 (2001) R274-R280
35. León-Velarde F., Richalet J.P., Chavez J.C., Kacimi R., Rivera-Chira M., Palacios J.A., and Clark D. Hypoxia- and normoxia-induced reversibility of autonomic control in Andean guinea pig heart. J. Appl. Physiol. 81 (1996) 2229-2234
36. Lundby C., Pilegaard H., Andersen J.L., van Hall G., Sander M., and Calbet J.A. Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. J. Exp. Biol. 207 (2004) 3865-3871
37. Lundby C., Araoz M., and van Hall G. Peak heart rate decreases with increasing severity of acute hypoxia. High Alt. Med. Biol. 2 (2001) 369-376
38. Macarlupú J.L., Buvry A., Morel O.E., León-Velarde F., Richalet J.P., and Favret F. Time course of ventilatory acclimatisation to hypoxia in a model of anemic transgenic mice. Resp. Physiol. Neurobiol. 153 (2006) 14-22
39. Maher J.T., Deniiston J.C., Wolfe D.L., and Cymerman A. Mechanism of the attenuated cardiac response to beta-adrenergic stimulation in chronic hypoxia. J. Appl. Physiol. 44 (1978) 647-651
40. Mardon K., Merlet P., Syrota A., and Maziere B. Effects of 5-day hypoxia on cardiac adrenergic neurotransmission in rats. J. Appl. Physiol. 85 (1998) 890-897
41. O2 max of trained and untrained subjects. J. Sports Sci. 11 (1993) 37-42
42. Mathieu-Costello O. Muscle adaptation to altitude: tissue capillarity and capacity for aerobic metabolism. High Alt. Med. Biol. 2 (2001) 413-425
43. Mazzeo R.S., and Grantham P.A. Norepinephrine turnover in various tissues at rest and during exercise: evidence for a training effect. Metabolism 38 (1989) 479-483
44. Mazzeo R.S., Bender P.R., Brooks G.A., Butterfield G.E., Groves B.M., Sutton J.R., Wolfel E.E., and Reeves J.T. Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am. J. Physiol. 261 (1991) E419-E424
45. O2 max in moderate acute hypoxia in trained and untrained men. Int. J. Sports Med. 28 (2007) 186-192
46. Noakes T.D. Physiological models to understand exercise fatigue and the adaptations that predict or enhance athletic performance. Scand. J. Med. Sci. Sports 10 (2000) 123-145
47. Olfert I.M., Breen E.C., Mathieu-Costello O., and Wagner P.D. Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle. J. Appl. Physiol. 90 (2001) 1532-1538
48. Olfert I.M., Breen E.C., Mathieu-Costello O., and Wagner P.D. Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia. J. Appl. Physiol. 91 (2001) 1176-1184
49. Pei J.M., Yu X.C., Fung M.L., Zhou J.J., Cheung C.S., Wong N.S., Leung M.P., and Wong T.M. Impaired G(s)alpha and adenylyl cyclase cause beta-adrenoceptor desensitisation in chronically hypoxic rat hearts. Am. J. Physiol. Cell. Physiol. 279 (2000) C1455-C1463
50. Richalet J.P., Souberbielle J.C., Antezana A.M., Dechaux M., Le Trong J.L., Bienvenu A., Daniel F., Blanchot C., and Zittoun J. Control of erythropoiesis in humans during prolonged exposure to the altitude of 6542 m. Am. J. Physiol. 266 (1994) R756-R764
51. Richalet J.P. The heart and adrenergic system. In: Sutton J.R., Coates G., and Remmers J.E. (Eds). Hypoxia, The Adaptations (1990), Dekker, Philadelphia, PA 231-245
52. Richalet J.P., Mehdioui H., Rathat C., Vignon P., Kéromès A., Herry J.P., Sabatier C., Tanche M., and Lhoste F. Acute hypoxia decreases cardiac response to catecholamines in exercising humans. Int. J. Sports Med. 9 (1988) 157-162
53. Richalet J.P., Larmignat P., Rathat C., Kéromès A., Baud P., and Lhoste F. Decreased human cardiac response to isoproterenol infusion in acute and chronic hypoxia. J. Appl. Physiol. 65 (1988) 1957-1961
54. Richalet J.P., Le-Trong J.L., Rathat C., Merlet P., Bouissou P., Kéromès A., and Veyrac P. Reversal of hypoxia-induced decrease in human cardiac response to isoproterenol infusion. J. Appl. Physiol. 67 (1989) 523-527
55. Richalet J.P., Merlet P., Bourguignon M., Le Trong J.L., Kéromès A., Rathat C., Jouve B., Hot M.A., Castaigne A., and Syrota A. MIBG scintigraphic assessment of cardiac adrenergic activity in response to altitude hypoxia. J. Nucl. Med. 31 (1990) 34-37
56. Richalet J.P. Oxygen sensors in the organism. Examples of regulation under altitude hypoxia in mammals. Comp. Biochem. Physiol. 118A (1997) 9-14
57. Richalet J.P., and Herry J.P. Médecine de l'alpinisme et des Sports de Montagne. fourth ed. (2006), Masson, Paris
58. Richalet J.P. A proposed classification of environmental adaptation: the example of high altitude. Rev. Env. Sci. Biotechnol. 6 (2007) 223-229
59. Savard G.K., Areskog N.H., and Saltin B. Cardiovascular response to exercise in humans following acclimatization to extreme altitude. Acta Physiol. Scand. 154 (1995) 499-509
60. Seals D.R., Johnson D.G., and Fregosi R.F. Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J. Appl. Physiol. 71 (1991) 1032-1040
61. Voelkel N.F., Hegstrand L., Reeves J.T., McMurty I.F., and Molinoff P.B. Effects of hypoxia on density of beta-adrenergic receptors. J. Appl. Physiol. 50 (1981) 363-366
62. O2 max at sea level and altitude. Respir. Physiol. 106 (1996) 329-343
63. Wagner P.D. Reduced maximal cardiac output at altitude-mechanisms and significance. Respir. Physiol. 120 (2000) 1-11
64. Wenzlaff H., Stein B., and Teschemacher H. Diminution of contractile response by kappa-opioid receptor agonists in isolated rat ventricular cardiomyocytes is mediated via a pertussis toxin-sensitive G-protein. Naunyn Schmiedebergs Arch. Pharmacol. 358 (1998) 360-366
65. Wolfe B.B., and Voelkel N.F. Effects of hypoxia on atrial muscarinic cholinergic receptors and cardiac parasympathetic responsiveness. Biochem. Pharmacol. 32 (1983) 1999-2002
66. Wong T.M., and Shan J. Modulation of sympathetic actions on the heart by opioid receptor stimulation. J. Biomed. Sci. 8 (2001) 299-306
67. Woorons X., Mollard P., Lamberto C., Letournel M., and Richalet J.P. Effect of acute hypoxia on maximal exercise in trained and sedentary women. Med. Sci. Sports Exerc. 37 (2005) 147-154