Induction of Autologous Graft-versus-Host Disease: Results of a Randomized Prospective Clinical Trial in Patients with Poor Risk Lymphoma

Biology of Blood and Marrow Transplantation

Volumn 13, Issue 10, 2007, Pages 1185-1191

  Bolaños Meade, Javier ^a   Garrett Mayer, Elizabeth ^a   Luznik, Leo ^a   Anders, Viki ^a   Webb, Jennifer ^a   Fuchs, Ephraim J ^a   Huff, Carol Ann ^a   Matsui, William ^a   Borrello, Ivan M ^a   Brodsky, Robert ^a   Kasamon, Yvette L ^a   Swinnen, Lode J ^a   Flinn, Ian W ^a   Ambinder, Richard F ^a   Jones, Richard J ^a   Hess, Allan D ^a   Vogelsang, Georgia B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Autologous graft versus host disease; Autologous stem cell transplant; Graft versus host disease; Hodgkin lymphoma; Lymphoma

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 2;

ADULT; ARTICLE; AUTOLOGOUS GRAFT VERSUS HOST REACTION; AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; CANCER RESISTANCE; CANCER RISK; CANCER SURVIVAL; CAPILLARY LEAK SYNDROME; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG FATALITY; DRUG FEVER; DRUG TOLERABILITY; DRUG WITHDRAWAL; EOSINOPHILIA; FEMALE; FLU LIKE SYNDROME; GRAFT VERSUS HOST REACTION; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOLOGY; INTERSTITIAL PNEUMONIA; KIDNEY FAILURE; LIVER FAILURE; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MORTALITY; NONHODGKIN LYMPHOMA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS SYNDROME; SIDE EFFECT; SKIN TOXICITY; STEM CELL MOBILIZATION;

ADULT; CYCLOSPORINE; FEMALE; GRAFT VS TUMOR EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HODGKIN DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-2; LYMPHOMA, NON-HODGKIN; MALE; NEOPLASM RECURRENCE, LOCAL; SALVAGE THERAPY; SURVIVAL ANALYSIS; SYNDROME; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, AUTOLOGOUS;

EID: 34548689612     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2007.06.011     Document Type: Article

References (39)

1. Akpek G., Ambinder R.F., Piantadosi S., et al. Long-term results of blood and marrow transplantation for Hodgkin's lymphoma. J Clin Oncol 19 (2001) 4314-4321
2. Kasamon Y.L., Jones R.J., Diehl L.F., et al. Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma. Biol Blood Marrow Transplant 11 (2005) 39-46
3. Aksentijevich I., Jones R.J., Ambinder R.F., Garrett-Mayer E., and Flinn I.W. Autologous versus allogeneic blood and marrow transplantation for relapsed diffuse large cell non-Hodgkin's lymphoma. Biol Blood Marrow Transplant 12 (2006) 965-972
4. Rapoport A.P., Guo C., Badros A., et al. Autologous stem cell transplantation followed by consolidation chemotherapy for relapsed or refractory Hodgkin's lymphoma. Bone Marrow Transplant 34 (2004) 883-890
5. Jones R.J., Ambinder R.F., Piantadosi S., and Santos G.W. Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation. Blood 77 (1991) 649-653
6. van Besien K., Sobocinski K.A., Rowlings P.A., et al. Allogeneic bone marrow transplantation for low-grade lymphoma. Blood 92 (1998) 1832-1836
7. Peniket A.J., Ruiz de Elvira M.C., Taghipour G., et al. An EBMT registry matched study of allogeneic stem cell transplants for lymphoma: allogeneic transplantation is associated with a lower relapse rate but a higher procedure-related mortality rate than autologous transplantation. Bone Marrow Transplant 31 (2003) 667-678
8. Jones R.J., Vogelsang G.B., Hess A.D., et al. Induction of graft-versus-host disease after autologous bone marrow transplantation. Lancet 333 (1989) 754-757
9. Vogelsang G.B., Jones R.J., Hess A.D., Geller R., Schucter L., and Santos G.W. Induction of autologous graft-versus-host disease. Transplant Proc 21 1 Pt 3 (1989) 2997-2998
10. Yeager A.M., Vogelsang G.B., Jones R.J., Farmer E.R., Hess A.D., and Santos G.W. Cyclosporine-induced graft-versus-host disease after autologous bone marrow transplantation for acute myeloid leukemia. Leuk Lymphoma 11 (1993) 215-220
11. Yeager A.M., Vogelsang G.B., Jones R.J., et al. Induction of cutaneous graft-versus-host disease by administration of cyclosporine to patients undergoing autologous bone marrow transplantation for acute myeloid leukemia. Blood 79 (1992) 3031-3035
12. Hess A.D., Horwitz L., Beschorner W.E., and Santos G.W. Development of graft-vs.-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity. J Exp Med 161 (1985) 718-730
13. Noga S.J., Horwitz L., Kim H., Laulis M.K., and Hess A.D. Interferon-gamma potentiates the antitumor effect of cyclosporine-induced autoimmunity. J Hematother 1 (1992) 75-84
14. Geller R.B., Esa A.H., Beschorner W.E., Frondoza C.G., Santos G.W., and Hess A.D. Successful in vitro graft-versus-tumor effect against an Ia-bearing tumor using cyclosporine-induced syngeneic graft-versus-host disease in the rat. Blood 74 (1989) 1165-1171
15. Soiffer R.J., Murray C., Cochran K., et al. Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation. Blood 79 (1992) 517-526
16. Soiffer R.J., Murray C., Gonin R., and Ritz J. Effect of low-dose interleukin-2 on disease relapse after T-cell-depleted allogeneic bone marrow transplantation. Blood 84 (1994) 964-971
17. Miura Y., Ueda M., Zeng W., et al. Induction of autologous graft-versus-host disease with cyclosporin A after peripheral blood stem cell transplantation: analysis of factors affecting induction. J Allergy Clin Immunol 106 (2000) S51-S57
18. Vogelsang G., Bitton R., Piantadosi S., et al. Immune modulation in autologous bone marrow transplantation: cyclosporine and gamma-interferon trial. Bone Marrow Transplant 24 (1999) 637-640
19. Przepiorka D., Weisdorf D., Martin P., et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant 15 (1995) 825-828
20. Gray R.J. A class of k-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 16 (1988) 1141-1154
21. Philip T., Armitage J.O., Spitzer G., et al. High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. N Engl J Med 316 (1987) 1493-1498
22. Bolaños-Meade J., and Vogelsang G.B. Acute graft-versus-host disease. Clin Adv Hematol Oncol 2 (2004) 672-682
23. Ratanatharathorn V., Uberti J., Karanes C., et al. Phase I study of alpha-interferon augmentation of cyclosporine-induced graft versus host disease in recipients of autologous bone marrow transplantation. Bone Marrow Transplant 13 (1994) 625-630
24. Wu J.M., Bensen-Kennedy D., Miura Y., et al. The effects of interleukin 10 and interferon gamma cytokine gene polymorphisms on survival after autologous bone marrow transplantation for patients with breast cancer. Biol Blood Marrow Transplant 11 (2005) 455-464
25. Miura Y., Thoburn C.J., Bright E.C., et al. Characterization of the T-cell repertoire in autologous graft-versus-host disease (GVHD): evidence for the involvement of antigen-driven T-cell response in the development of autologous GVHD. Blood 98 (2001) 868-876
26. Miura Y., Ueda M., Takami A., Shiobara S., Nakao S., and Hess A.D. Enhancement of cyclosporin A-induced autologous graft-versus-host disease after peripheral blood stem cell transplantation by utilizing selected CD34(+) cells. Bone Marrow Transplant 32 (2003) 785-790
27. Miura Y., Thoburn C.J., Bright E.C., Chen W., Nakao S., and Hess A.D. Cytokine and chemokine profiles in autologous graft-versus-host disease (GVHD): interleukin 10 and interferon gamma may be critical mediators for the development of autologous GVHD. Blood 100 (2002) 2650-2658
28. Vela-Ojeda J., García-Ruiz Esparza M.A., Reyes-Maldonado E., et al. Peripheral blood mobilization of different lymphocyte and dendritic cell subsets with the use of intermediate doses of G-CSF in patients with non-Hodgkin's lymphoma and multiple myeloma. Ann Hematol 85 (2006) 308-314
29. Condomines M., Quittet P., Lu Z.Y., et al. Functional regulatory T cells are collected in stem cell autografts by mobilization with high-dose cyclophosphamide and granulocyte colony-stimulating factor. J Immunol 176 (2006) 6631-6639
30. Kusnierz-Glaz C.R., Still B.J., Amano M., et al. Granulocyte colony-stimulating factor-induced comobilization of CD4- CD8- T cells and hematopoietic progenitor cells (CD34+) in the blood of normal donors. Blood 89 (1997) 2586-2595
31. Fischer A.C., and Hess A.D. Age-related factors in cyclosporine-induced syngeneic graft-versus-host disease: regulatory role of marrow-derived T lymphocytes. J Exp Med 172 (1990) 85-94
32. Fischer A.C., Laulis M.K., Horwitz L., Beschorner W.E., and Hess A. Host resistance to cyclosporine induced syngeneic graft-versus-host disease. Requirement for two distinct lymphocyte subsets. J Immunol 143 (1989) 827-832
33. Wu D.Y., and Goldschneider I. Cyclosporin A-induced autologous graft-versus-host disease: a prototypical model of autoimmunity and active (dominant) tolerance coordinately induced by recent thymic emigrants. J Immunol 162 (1999) 6926-6933
34. Sica S., Chiusolo P., Salutari P., et al. Autologous graft-versus-host disease after CD34+-purified autologous peripheral blood progenitor cell transplantation. J Hematother Stem Cell Res 9 (2000) 375-379
35. Jenkins M.K., Schwartz R.H., and Pardoll D.M. Effects of cyclosporine A on T cell development and clonal deletion. Science 241 (1988) 1655-1658
36. van der Wall E., Horn T., Bright E., et al. Autologous graft-versus-host disease induction in advanced breast cancer: role of peripheral blood progenitor cells. Br J Cancer 83 (2000) 1405-1411
37. Giralt S., Weber D., Colome M., et al. Phase I trial of cyclosporine-induced autologous graft-versus-host disease in patients with multiple myeloma undergoing high-dose chemotherapy with autologous stem-cell rescue. J Clin Oncol 15 (1997) 667-673
38. Streetly M., Kazmi M., Radia D., Hoyle C., and Schey S.A. Second autologous transplant with cyclosporin/interferon alpha-induced graft versus host disease for patients who have failed first-line consolidation. Bone Marrow Transplant 33 (2004) 1131-1135
39. Marín G.H., Menna M.E., Bergna M.I., et al. Induction of anti-tumor activity following autologous stem cell transplantation: immunotherapeutic implications. Transplant Proc 33 (2001) 2004-2007