Oestrogen stimulates endothelial progenitor cells via oestrogen receptor-α

Clinical Endocrinology

Volumn 67, Issue 4, 2007, Pages 520-525

  Foresta, Carlo ^a   Zuccarello, Daniela ^a   Biagioli, Andrea ^a   De Toni, Luca ^a   Prana, Elisa ^a   Nicoletti, Valentina ^a   Ambrosini, Guido ^a   Ferlin, Alberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

ARTICLE; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; STEM CELLS; STIMULATION, CHEMICAL;

EID: 34548679605     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.02918.x     Document Type: Article

References (26)

1. Venkov, C.D., Rankin, A.B. Vaughan, D.E. (1996) Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Circulation, 94, 727 733.
2. Iafrati, M.D., Karas, R.H., Aronovitz, M., Kim, S., Sullivan, T.R. Jr., Lubahn, D.B., O'Donnell, T.F. Jr., Korach, K.S. Mendelsohn, M.E. (1997) Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nature Medicine, 3, 545 548.
3. Orshal, J.M. Khalil, R.A. (2004) Gender, sex hormones, and vascular tone. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 286, R233 R249.
4. Mendelsohn, M.E. Karas, R.H. (1999) The protective effects of estrogen on the cardiovascular system. New England Journal of Medicine, 340, 1801 1811.
5. Iwakura, A., Luedemann, C., Shastry, S., Hanley, A., Kearney, M., Aikawa, R., Isner, J.M., Asahara, T. Losordo, D.W. (2003) Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation, 108, 3115 3121.
6. Karas, R.H., Schulten, H., Pare, G., Aronovitz, M.J., Ohlsson, C., Gustafsson, J.A. Mendelsohn, M.E. (2001) Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice. Circulation Research, 89, 534 539.
7. Brouchet, L., Krust, A., Dupont, S., Chambon, P., Bayard, F. Arnal, J.F. (2001) Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation, 103, 423 428.
8. Iwakura, A., Shastry, S., Luedemann, C., Hamada, H., Kawamoto, A., Kishore, R., Zhu, Y., Qin, G., Silver, M., Thorne, T., Eaton, L., Masuda, H., Asahara, T. Losordo, D.W. (2006) Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation, 113, 1605 1614.
9. Fontaine, V., Filipe, C., Werner, N., Gourdy, P., Billon, A., Garmy-Susini, B., Brouchet, L., Bayard, F., Prats, H., Doetschman, T., Nickenig, G. Arnal, J.F. (2006) Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization. American Journal of Pathology, 169, 1855 1862.
10. Hamada, H., Kim, M.K., Iwakura, A., Ii, M., Thorne, T., Qin, G., Asai, J., Tsutsumi, Y., Sekiguchi, H., Silver, M., Wecker, A., Bord, E., Zhu, Y., Kishore, R. Losordo, D.W. (2006) Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation, 114, 2261 2270.
11. Strehlow, K., Werner, N., Berweiler, J., Link, A., Dirnagl, U., Priller, J., Laufs, K., Ghaeni, L., Milosevic, M., Bohm, M. Nickenig, G. (2003) Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation, 107, 3059 3065.
12. Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G. Isner, J.M. (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275, 964 967.
13. Aicher, A., Zeiher, A.M. Dimmeler, S. (2005) Mobilizing endothelial progenitor cells. Hypertension, 45, 321 325.
14. Asahara, T. Kawamoto, T. (2004) Endothelial progenitor cells for postnatal vasculogenesis. American Journal of Physiology - Cell Physiology, 287, C572 C579.
15. Rafii, S. Lyden, D. (2003) Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nature Medicine, 9, 702 712.
16. Pare, G., Krust, A., Karas, R.H., Dupont, S., Aronovitz, M., Chambon, P. Mendelsohn, M.E. (2002) Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circulation Research, 90, 1087 1092.
17. Grady, D., Rubin, S.M., Petitti, D.B., Fox, C.S., Black, D., Ettinger, B., Ernster, V.L. Cummings, S.R. (1992) Hormone therapy to prevent disease and prolong life in postmenopausal women. Annals of Internal Medicine, 117, 1016 1037.
18. Stampfer, M.J., Colditz, G.A., Willett, W.C., Manson, J.E., Rosner, B., Speizer, F.E. Hennekens, C.H. (1991) Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. New England Journal of Medicine, 325, 756 762.
19. Villar, I.C., Francis, S., Webb, A., Hobbs, A.J. Ahluwalia, A. (2006) Novel aspects of endothelium-dependent regulation of vascular tone. Kidney International, 70, 840 853.
20. Williams, M.R., Westerman, R.A., Kingwell, B.A., Paige, J., Blombery, P.A., Sudhir, K. Komesaroff, P.A. (2001) Variations in endothelial function and arterial compliance during the menstrual cycle. Journal of Clinical Endocrinology and Metabolism, 86, 5389 5395.
21. Johns, A., Freay, A.D., Fraser, W., Korach, K.S. Rubanyi, G.M. (1996) Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice. Endocrinology, 137, 4511 4513.
22. Zhu, Y., Bian, Z., Lu, P., Karas, R.H., Bao, L., Cox, D., Hodgin, J., Shaul, P.W., Thoren, P., Smithies, O., Gustafsson, J.A. Mendelsohn, M.E. (2002) Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science, 295, 505 508.
23. Hristov, M., Erl, W. Weber, P.C. (2003) Endothelial progenitor cells: mobilization, differentiation, and homing. Arteriosclerosis, Thrombosis and Vascular Biology, 23, 1185 1189.
24. Hur, J., Yoon, C.H., Kim, H.S., Choi, J.H., Kang, H.J., Hwang, K.K., Oh, B.H., Lee, M.M. Park, Y.B. (2004) Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arteriosclerosis, Thrombosis and Vascular Biology, 24, 288 293.
25. Khalil, R.A. (2005) Sex hormones as potential modulators of vascular function in hypertension. Hypertension, 46, 249 254.
26. Imanishi, T., Kobayashi, K., Hano, T. Nishio, I. (2005) Effect of estrogen on differentiation and senescence in endothelial progenitor cells derived from bone marrow in spontaneously hypertensive rats. Hypertension Research, 28, 763 772.