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Volumn 55, Issue 9, 2007, Pages 1406-1411

N-monocarbamoyl derivatives of symmetrical diamines with antiviral activity

Author keywords

1,2 diaminocyclohexane; 2,6 diaminopyridine; Anti herpes simplex virus (HSV) 1; Plaque reduction assay; Symmetrical diamine; Urea

Indexed keywords

ACICLOVIR; DIAMINE DERIVATIVE; ISOCYANIC ACID DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; N MONOCARBAMOYL 2,6 DIAMINOPYRIDINE; N MONODODECANOUL 2,6 DIAMINOPYRIDINE; UNCLASSIFIED DRUG;

EID: 34548662626     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.1406     Document Type: Article
Times cited : (16)

References (14)
  • 9
    • 34548692793 scopus 로고    scopus 로고
    • In the reaction of 4c with DAP• HCl, we used the DAP salt elucidated by an elemental analysis and spectroscopic data as the starting material see Experimental; Method B
    • In the reaction of 4c with DAP• HCl, we used the DAP salt elucidated by an elemental analysis and spectroscopic data as the starting material (see Experimental; Method B).
  • 11
    • 34548683942 scopus 로고    scopus 로고
    • As an explanation of the difference in the stability of the products between cis-6c and (1R,2R)-6c, one could consider that the product cis-6c probably has the chair conformation with the amino group in an axial position and the thiourea group in an equatorial position predominantly. However, the product from (1R,2R)-2 (trans isomer of 1,2-diaminocyclohexane) requires both amino and thiourea group in the equatorial orientation. The fact that this diequatorial conformer is more stable than the former conformer of cis-6c by the steric hindrance could be estimated by the energy calculation of these conformers using the computer program CAChe version 6.1.12 (Fujitsu Limited, 2004, The results of calculation showed that minimized strain energy for (1R,2R)-6c, 30.63 kcal/mol) is lower than that of cis-6c, 30.47 kcal/mol) by an energy difference of 0.16 kcal/mol, an
    • a values contribute very little to the reactivity of diamines.
  • 14
    • 0038539929 scopus 로고    scopus 로고
    • 15) 15 Bernstein J., Stearns B., Dexter M., Lott W. A., J. Am. Chem. Soc., 69, 1147-1150 (1947).
    • 15) 15) Bernstein J., Stearns B., Dexter M., Lott W. A., J. Am. Chem. Soc., 69, 1147-1150 (1947).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.