Low and ultra low-dose estrogen therapy for climacteric symptom control - Preliminary report

International Journal of Fertility and Women's Medicine

Volumn 51, Issue 4, 2006, Pages 171-175

  Carranza Lira, Sebastián ^a   Gooch, Ana Luz Mac Gregor ^a   Velasco Díaz, Guillermina ^a   Solano, Jacqueline ^a   Arzola Paniagua, Angélica ^a  

^a Hospital Luis Castelazo Ayala   (Mexico)

Author keywords

Conjugated esterified estrogens; Estrogen therapy; HRT; HT; Low dose; Ultra low dose

Indexed keywords

ANDROGEN; CONJUGATED ESTROGEN; ESTROGEN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ESTROGEN THERAPY; FEMALE; HOT FLUSH; HUMAN; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; ANALYSIS OF VARIANCE; ANDROGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; ESTROGENS, CONJUGATED (USP); FEMALE; HOT FLASHES; HUMANS; MIDDLE AGED; POSTMENOPAUSE; TREATMENT OUTCOME;

EID: 34548658012     PISSN: 1534892X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. JAMA 288:321-333, 2002.
2. Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362:419-427, 2003.
3. Burger H, Archer D, Barlow D, et al: Practical recommendations for hormone replacement therapy on the peri- and postmenopause. Climacteric 7:210-216, 2004. (Pubitemid 38951703)
4. Ettinger B, Genant HK, Cann CE: Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med 104:40-44, 1987.
5. Gambacciani M, Ciaponi M, Cappagli B, et al: Effects of low-dose continuous combined estrogens and medroxyprogesterone acetate on menopausal symptoms, body weight, bone density, and metabolism in postmenopausal women. Am J Obstet Gynecol 185:1180-1185, 2001. (Pubitemid 33097384)
6. Rebar RW, Trabal J, Mortola J: Low-dose esterified estrogens (0.3mg/day): long-term and short-term effects on menopausal symptoms and quality of life in postmenopausal women. Climacteric 3:176-182, 2000.
7. Utian WH, Burry KA, Archer DF, et al. Efficacy and safety of low, standard, and high dosages of an estradiol transdermal system (Esclim) compared with placebo on vasomotor symptoms in highly symptomatic menopausal patients. Am J Obstet Gynecol 181:71-79, 1999. (Pubitemid 29343333)
8. Marx P, Schade G, Wilbourn S, et al: Low-dose (0.3 mg) synthetic conjugated estrogens A is effective for managing atrophic vaginitis. Maturitas 47:47-54, 2003. (Pubitemid 38050015)
9. Utian WH, Shoupe D, Bachmann G, et al: Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate. Fertil Steril 75:1065-1079, 2001. (Pubitemid 32522600)
10. Prestwood KM, Kenny AM, Kleppinger A, et al: Ultra low-dose micronized 17,-estradiol and bone density and bone metabolism in older women. JAMA 290:1042-1048, 2003. (Pubitemid 37430444)
11. Ettinger B: Unopposed ultra-low-dose estradiol: A new approach to osteoporosis prevention. J Fam Pract 2004, 53 Suppl: 17-19.
12. Cummings SR, Browner WS, Bauer D, et al: Endogenous Sex and calciotropic hormones and the risk of hip and vertebral fractures in older women: The Study of Osteoporotic Fractures. N Engl J Med 339:733-738, 1998 (Pubitemid 28417356)
13. Ettinger B, Pressman A, Sklarin P, et al: Associations between low levels of serum estradiol, bone density, and fractures among elderly women. J Clin Endocrinol Metab 83:2239-2243, 1998. (Pubitemid 28503008)
14. Archer DF, Dorin M, Lewis V, et al: Effects of lower doses of conjugated estrogens and medroxyprogesterone acetate on endometrial bleeding. Fertil Steril 2001, 75:1080-1087. (Pubitemid 32522601)