Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules

Biophysical Journal

Volumn 93, Issue 5, 2007, Pages

  Han, Lin ^a   Dean, Delphine ^b   Mao, Pan ^a   Ortiz, Christine ^a   Grodzinsky, Alan J ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; CALCIUM ION;

AQUEOUS SOLUTION; ARTICLE; ATOMIC FORCE MICROSCOPY; CARTILAGE; COMPRESSION; IONIC STRENGTH; MACROMOLECULE; MATERIALS; NANOANALYSIS; SHEAR STRESS;

EID: 34548648016     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.107.114025     Document Type: Article

References (13)

1. Hardingham, T. E., and A. J. Fosang. 1992. Proteoglycans: many forms and many functions. FASEB J. 6:861-870.
2. Maroudas, A. 1979. Physicochemical properties of articular cartilage. In Adult Articular Cartilage. M. A. R. Freeman, editor. Pitman Medical, London. 215-290.
3. Han, L., D. Dean, C. Ortiz, and A. J. Grodzinsky. 2007. Lateral nanomechanics of cartilage aggrecan macromolecules. Biophys. J. 92:1384-1398.
4. Dean, D., L. Han, C. Ortiz, and A. J. Grodzinsky. 2005. Nanoscale conformation and compressibility of cartilage aggrecan using microcontact printing and atomic force microscopy. Macromolecules. 38:4047-4049.
5. Dean, D., L. Han, A. J. Grodzinsky, and C. Ortiz. 2006. Compressive nanomechanics of opposing aggrecan macromolecules. J. Biomech. 39:2555-2565.
6. Tomlinson, G. A. 1929. The molecular theory of friction. Philos. Mag. 7:905-916.
7. Han, L., D. Dean, L. A. Daher, A. J. Grodzinsky, and C. Ortiz. 2006. Biomolecular adhesion between opposing cartilage aggrecan macromolecules. 52nd Orthopedic Research Society, Chicago, IL. 361.
8. Grodzinsky, A. J., V. Roth, E. Myers, W. D. Grossman, and V. C. Mow. 1981. The significance of electromechanical and osmotic forces in the nonequilibrium swelling behavior of articular cartilage in tension. J. Biomech. Eng. Trans. ASME. 103:221-231.
9. Parker, K. H., C. P. Winlove, and A. Maroudas. 1988. The theoretical distributions and diffusivities of small ions in chondroitin sulphate and hyaluronate. Biophys. Chem. 32:271-282.
10. MacGregor, E. A., and J. M. Bowness. 1971. Interaction of proteoglycans and chondroitin sulfates with calcium or phosphate ions. Can. J. Biochem. 49:417-425.
11. Hunter, G. K., K. S. Wong, and J. J. Kim. 1988. Binding of calcium to glycosaminoglycans: an equilibrium dialysis study. Arch. Biochem. Biophys. 260:161-167.
12. Ehrlich, S., N. Wolff, R. Schneiderman, A. Maroudas, K. H. Parker, and C. P. Winlove. 1998. The osmotic pressure of chondroitin sulphate solutions. Biorheology. 35:383-397.
13. Setton, L. A., W. B. Zhu, and V. C. Mow. 1993. The biphasic poroviscoelastic behavior of articular cartilage: role of the surface zone in governing the compressive behavior. J. Biomech. 26:581-592.