Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-κB activation and NF-κB-regulated antiapoptotic gene products

Journal of Immunology

Volumn 179, Issue 3, 2007, Pages 1926-1933

  Sethi, Gautam ^a   Kwang, Seok Ahn ^a   Xia, Dianren ^a   Kurie, Jonathan M ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; FLICE INHIBITORY PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN BCL 2; PROTEIN BCL XL; SURVIVIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; X LINKED INHIBITOR OF APOPTOSIS; APOPTOSIS REGULATORY PROTEIN; GELATINASE B; PTGS2 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE DELETION; GENE EXPRESSION; GENE TRANSLOCATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; GENE TARGETING; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; CYCLIN D1; CYCLOOXYGENASE 2; DOWN-REGULATION; FIBROBLASTS; GENE DELETION; GENE TARGETING; MAP KINASE KINASE 4; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548643396     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.3.1926     Document Type: Article

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