Valsartan improves insulin sensitivity without altering vascular function in healthy overweight adults without the metabolic syndrome

Metabolic Syndrome and Related Disorders

Volumn 5, Issue 3, 2007, Pages 255-261

  Brook, Robert D ^a,b   Bard, Robert L ^a   Kehrer, Christine ^a   Bodary, Peter F ^a   Eitzman, Daniel T ^a   Rajagopalan, Sanjay ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCERYL TRINITRATE; PLACEBO; VALSARTAN;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; INSULIN SENSITIVITY; MALE; METABOLIC SYNDROME X; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; WAIST HIP RATIO;

EID: 34548620169     PISSN: 15404196     EISSN: None     Source Type: Journal    
DOI: 10.1089/met.2007.0002     Document Type: Article

References (15)

1. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001;88:1264-1269.
2. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction. Molecular and pathophysiological mechanisms. Circulation 2006;113:1888-1904.
3. Brook RD. Obesity, weight loss, and vascular function. Endocrine 2006;29:21-25.
4. Ritchie SA, Ewart MA, Perry CG, Connell JM, Salt IP. The role of insulin and the adipocytokines in regulation of vascular endothelial function. Clin Sci 2004; 107:519-532.
5. Giacchetti G, Faloia E, Mariniello B, Sardu C, Gatti C, Camilloni MA, Guerrieri M, Mantero F. Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects. Am J Hypertens 2002;15:381-388.
6. Shinozaki K, Ayajiki K, Nishio Y, Sugaya T, Kashiwagi A, Okamura T. Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance. Hypertension 2004;43: 255-262.
7. Sola S, Mir MQS, Cheema FA, Khan-Merchant N, Menon RG, Parthasarathy S, Khan BV. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome. Circulation 2005;111:343-348.
8. Engeli S, Bohnke J, Gorzelniak K, Janke J, Schling P, Bader M, Luft FC, Sharma AM. Weight loss and the renin-angiotensin system. Hypertension 2005;45:1-7.
9. Townsend RR. Angiotensin and insulin resistance: Conspiracy theory. Cur Hypertens Rep 2003;5:110-116.
10. Mollnau H, Wendt M, Szocs K, Lassegue B, Schulz E, Oelze M, Li H, Bodenschatz M, August M, Kleschyov AL, Tsilimingas N, Walter U, Forstermann U, Meinertz T, Griendling K, Munzel T. Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res 2002;90:58-65.
11. Blake GJ, Otvos JD, Rifai N, Ridker PM. Low-density lipoprotein particle concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women. Circulation 2002;106:1930-1937.
12. Mancia G, Grassi G, Zanchetti A. New-onset diabetes and antihypertensive drugs. J Hypertens 2006;24:3-10.
13. Yeni-Komshian H, Carantoni M, Abassi F, Reaven GM. Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy non-diabetic volunteers. Diabetes Care 2000;23:171-175.
14. Tuan CY, Abbasi F, Lamendola, McLaughlin T, Reaven G. Usefulness of plasma glucose and insulin concentrations in identifying patients with insulin resistance. Am J Cardiol 2003;92:606-610.
15. Monzillo LU, Hamdy O. Evaluation of insulin sensitivity in clinical practice and in research settings. Nutrition Reviews 2003;61:397-412.