Antiphospholipid antibody syndrome: The flow cytometric annexin A5 competition assay as a diagnostic tool

British Journal of Haematology

Volumn 139, Issue 1, 2007, Pages 113-120

  Tomer, A ^a   Bar Lev, S ^a   Fleisher, S ^a   Shenkman, B ^b   Friger, M ^c   Abu Shakra, M ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Annexin A5; Anti phospholipid syndrome; Anticardiolipin; Flow cytometry; Lupus anticoagulant

Indexed keywords

ANTICOAGULANT PROTEIN; CARDIOLIPIN ANTIBODY; LIPOCORTIN 5; THROMBOCYTE ANTIBODY;

ANTIPHOSPHOLIPID SYNDROME; ARTERY THROMBOSIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIAGNOSTIC PROCEDURE; FEMALE; FLOW CYTOMETRY; GESTATION PERIOD; HUMAN; LABORATORY TEST; LUPUS ERYTHEMATOSUS; MAJOR CLINICAL STUDY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY; THROMBOCYTOPENIA;

ADULT; ANNEXIN A5; ANTIBODIES, ANTICARDIOLIPIN; ANTIPHOSPHOLIPID SYNDROME; AREA UNDER CURVE; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CASE-CONTROL STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; LUPUS COAGULATION INHIBITOR; MALE; MIDDLE AGED; PLATELET ACTIVATION; PREGNANCY; PROTEIN BINDING; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 34548588689     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06751.x     Document Type: Article

References (28)

1. Andree, H.A.M., Hermens, W.T., Hemker, H.C. Willems, G.M. (1992) Displacement of factor Va by annexin V. In : Phospholipid Binding and Anticoagulant Action of Annexin A5 (ed. by H.A.M. Andree pp. 73 85. Universitaire Press Maastricht, Maastricht, The Netherlands.
2. Brandt, J.T., Triplett, D.A., Alving, B. Scharrer, I. (1995) Criteria for the diagnosis of lupus anticoagulant: an update on behalf of the subcommittee on lupus anticoagulant/antiphospholipid antibody of the Scientific and Stratification Committee of the ISTH. Journal of Thrombosis and Haemostasis, 74, 1185 1190.
3. Giannakopoulos, B., Passam, F., Rahgozar, S. Krilis, S.A. (2007) Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood, 109, 422 430.
4. Hughes, G.R.V. (1993) The antiphospholipid syndrome: ten years on. Lancet, 342, 341 344.
5. de Laat, H.B., Derksen, R.H., Urbanus, R.T., Roest, M. de Groot, P.G. (2004) Beta2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome. Blood, 104, 3598 3602.
6. de Laat, B., Wu, X.X., van Lummel, M., Derksen, R.H., de Groot, P.G. Rand, J.H. (2006) Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5. Blood, 109, 1490 1494.
7. Levine, J.S., Ware Branch, D. Rauch, J. (2002) The antiphospholipid syndrome. New England Journal of Medicine, 346, 752 763.
8. Lockshin, M.D. (1997) Antiphospholipid antibody. Journal of the American Medical Association, 227, 1549 1551.
9. Love, P.E. Santoro, S.A. (1990) Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders: prevalence and clinical significance. Annals of Internal Medicine, 112, 682 698.
10. Miyakis, S., Robertson, S.A. Krilis, S.A. (2004) Beta-2 glycoprotein I and its role in antiphospholipid syndrome-lessons from knockout mice. Clinical Immunology 112, 136 143.
11. Miyakis, S., Lockshin, M.D., Atsumi, T., Branch, D.W., Brey, R.L., Cervera, R., Derksen, R.H.W.M., De Groot, P.G., Koike, T., Meroni, P.L., Reber, G., Shoenfeld, Y., Tincani, A., Vlachoyiannopoulos, P.G. Krilis, S.A. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. Journal of Thrombosis and Haemostasis, 4, 295 306.
12. Ortel, T.L. (2006) The antiphospholipid syndrome: what are we really measuring? How do we measure it? And how do we treat it? Journal of Thrombosis and Thrombolysis, 21, 79 83.
13. Petri, M. (2002) Classification and epidemiology of the antiphospholipid syndrome. In : The Antiphospholipid SyndromeII: Autoimmune Thrombosis (ed. by R.A. Asherson, R. Cervera, J.C. Piette Y. Shoenfeld pp. 11 20. Elsevier, St Louis, MO.
14. Pierangeli, S.S. (2006) In search for a receptor for antiphospholipid antibodies on target cells. Journal of Thrombosis and Haemostasis, 4, 1680 1690.
15. Rand, J.H., Wu, X.X., Andree, H.A., Lockwood, C.J., Guller, S., Scher, J. Harpel, C. (1997) Pregnancy loss in the antiphospholipid-antibody syndrome - a possible thrombogenic mechanism. New England Journal of Medicine, 337, 154 160.
16. Rand, J.H., Wu, X.X., Andree, H.A., Ross, J.B., Rusinova, E., Gascon-Lema, M.G., Calandri, C. Harpel, P.C. (1998) Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a ''lupus procoagulant" phenomenon. Blood, 92, 1652 1660.
17. Rand, J.H., Wu, X.X., Quinn, A.S., Chen, P.P., McCrae, K.R., Bovill, E.G. Taatjes, D.J. (2003) Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. American Journal of Pathology, 163, 1193 1200.
18. Rand, J.H., Wu, X.X., Lapinski, R., van Heerde, W.L., Reutelingsperger, C.P., Chen, P.P. Ortel, T.L. (2004) Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome. Blood, 104, 2783 2790.
19. Robertson, B. Greaves, M. (2006) Antiphospholipid syndrome: an evolving story. Blood Reviews, 20, 201 212.
20. Thiagarajan, P. Tait, J.F. (1990) Binding of annexin V/placental anticoagulant protein I to platelets. Journal of Biological Chemistry, 265, 17420 17423.
21. Tomer, A. (1997) Rapid, sensitive and specific functional flow cytometric assay for the diagnosis of heparin-induced thrombocytopenia(HIT). British Journal of Haematology, 98, 648 656.
22. Tomer, A. (2002) Antiphospholipid antibody syndrome (APLAS): rapid sensitive and specific flow cytometric assay for determination of anti-platelet-phospholipid autoantibodies. Journal of Laboratory and Clinical Medicine, 139, 147 154.
23. Tomer, A. (2004) Platelet activation as a marker for in vivo prothrombotic activity: detection by flow cytometry. The Journal of Biological Regulators and Homeostatic Agents, 18, 134 140.
24. Tomer, A., Stahl, C., McClure, H., Anderson, D., Myers, L., Liehl, E. Winton, E.F. (1993) Effects of rhGM-CSF on platelet survival and activation using a non-human primate model. Experimental Hematology, 21, 1577 1582.
25. Tomer, A., Kasey, S. Eckman, J.R. (2001a) Thrombogenesis in sickle cell disease. Journal of Laboratory and Clinical Medicine, 137, 398 407.
26. Tomer, A., Kasey, S. Eckman, J.R. (2001b) Reduction of pain episodes and prothrombotic activity in sickle cell disease by dietary n-3 fatty acids. Journal of Thrombosis and Haemostasis, 85, 966 974.
27. Tomer, A., Koziol, J. McMillan, R. (2005) Autoimmune thrombocytopenia: flow cytometric determination of circulating autoantibodies against platelet specific receptors. Journal of Thrombosis and Haemostasis, 3, 74 78.
28. Willems, G.M., Janssen, M.P., Comfurius, P., Galli, M., Zwaal, R.F. Bevers, E.M. (2000) Competition of annexin V and anticardiolipin antibodies for binding to phosphatidylserine containing membranes. Biochemistry, 39, 1982 1989.