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Complex 1 is now readily available in high yield through a very simple procedure; see: Sentets, S.; Rodriguez Martinez, M.; Vendier, L.; Donnadieu, B.; Hue, V.; Lugan, N.; Lavigne, G. J. Am. Chem. Soc. 2005, 127, 14554.
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For a straightforward preparation of this ligand, see
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For a straightforward preparation of this ligand, see: Laue, S.; Greiner, L.; Wöltinger, J.; Liese, A. Adv. Synth. Catal 2001, 343.
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34548578205
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By contrast, with 2-bromobenzaldehyde, namely, in the absence of a better directing group than the oxygen of the acyl, we do observe normal activation at the ortho position, with competing cleavage of C-Br and C-H bonds (Benhamou, L.; Cesar, V.; Lugan. N.; Lavigne, G., in preparation).
-
By contrast, with 2-bromobenzaldehyde, namely, in the absence of a better directing group than the oxygen of the acyl, we do observe "normal" activation at the ortho position, with competing cleavage of C-Br and C-H bonds (Benhamou, L.; Cesar, V.; Lugan. N.; Lavigne, G., in preparation).
-
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62
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34548551930
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Although the hydroacylation on diphenylacetylene occurs as a formal syn addition, the CIP descriptor of the stilbenyl moiety is E according to the priority rules
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Although the hydroacylation on diphenylacetylene occurs as a formal syn addition, the CIP descriptor of the stilbenyl moiety is E according to the priority rules.
-
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63
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34548560031
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For selected examples of such a coordination mode with preformed α,β-unsaturated ketones, see
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For selected examples of such a coordination mode with preformed α,β-unsaturated ketones, see:
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