Effects of organisational oestradiol on adult immunoreactive oestrogen receptors (α and β) in the male mouse brain

Journal of Neuroendocrinology

Volumn 19, Issue 10, 2007, Pages 767-772

  Kudwa, A E ^a   Harada, N ^b   Honda, S I ^b   Rissman, E F ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

POA; Reproduction; Sex differences; Sexual differentiation; VMN

Indexed keywords

AROMATASE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATED MALE; CONTROLLED STUDY; ESTROGEN ACTIVITY; GENOTYPE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOCYTOCHEMISTRY; MALE; MEDIAL PREOPTIC AREA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPRODUCTION; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; WILD TYPE;

ANIMALS; AROMATASE; CRITICAL PERIOD (PSYCHOLOGY); ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PREOPTIC AREA; SEX DIFFERENTIATION; TISSUE DISTRIBUTION; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 34548574848     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2007.01585.x     Document Type: Article

References (36)

1. McCarthy MM, Schlenker EH, Pfaff DW. Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain. Endocrinology 1993; 133: 433-439.
2. Toran-Allerand CD, Hashimoto K, Greenough WT, Saltarelli M. Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro. III. Effects of estrogen on dendritic differentiation. Brain Res 1983; 283: 97-101.
3. Toran-Allerand CD. Estrogen and the brain. Beyond ER-alpha, ER-beta, and 17beta-estradiol. Ann NY Acad Sci 2005; 1052: 136-144.
4. White R, Lees JA, Needham M, Ham J, Parker M. Structural organization and expression of the mouse estrogen receptor. Mol Endocrinol 1987; 1: 735-744.
5. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA 1998; 95: 15677-15682.
6. Shughrue PJ, Scrimo PJ, Merchenthaler I. Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain. Endocrinology 1998; 139: 5267-5270.
7. Bakker J, Pool CW, Sonnemans M, van Leeuwen FW, Slob AK. Quantitative estimation of estrogen and androgen receptor-immunoreactive cells in the forebrain of neonatally estrogen-deprived male rats. Neuroscience 1997; 77:911-919.
8. Kuhnemann S, Brown TJ, Hochberg RB, MacLusky NJ. Sexual differentiation of estrogen receptor concentrations in the rat brain: Effects of neonatal testosterone exposure. Brain Res 1995; 691: 229-234.
9. Agarwal VR, Sinton CM, Liang C, Fisher C, German DC, Simpson ER. Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice. Mol Cell Endocrinol 2000; 162: 9-16.
10. McGinnis MY, Krey LC, MacLusky NJ, McEwen BS. Steroid receptor levels in intact and ovariectomized estrogen-treated rats: An examination of quantitative, temporal and endocrine factors influencing the efficacy of an estradiol stimulus. Neuroendocrinology 1981; 33: 158-165.
11. Shughrue PJ, Bushnell CD, Dorsa DM. Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: A comparison with ovariectomized females and intact males. Endocrinology 1992; 131: 381-388.
12. Yuan H, Bowlby DA, Brown TJ, Hochberg RB, MacLusky NJ. Distribution of occupied and unoccupied estrogen receptors in the rat brain: Effects of physiological gonadal steroid exposure. Endocrinology 1995; 136: 96-105.
13. Honda S, Harada N, Ito S, Takagi Y, Maeda S. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun 1998; 252: 445-449.
14. Bakker J, Honda S, Harada N, Balthazart J. Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice. Horm Behav 2004; 46: 1-10.
15. Gatewood JD, Wills A, Shetty S, Xu J, Arnold AP, Burgoyne PS, Rissman EF. Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci 2006; 26: 2335-2342.
16. Arnold AP, Burgoyne PS. Are XX and XY brain cells intrinsically different? Trends Endocrinol Metab 2004; 15: 6-11.
17. Nomura M, Korach KS, Pfaff DW, Ogawa S. Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on its ligand in a brain region-specific manner. Brain Res Mol Brain Res 2003; 110: 7-14.
18. Temple JL, Fugger HN, Li X, Shetty SJ, Gustafsson J, Rissman EF. Estrogen receptor beta regulates sexually dimorphic neural responses to estradiol. Endocrinology 2001; 142: 510-513.
19. Greco B, Allegretto EA, Tetel MJ, Blaustein JD. Coexpression of ER beta with ER alpha and progestin receptor proteins in the female rat forebrain: Effects of estradiol treatment. Endocrinology 2001; 142: 5172-5181.
20. Bakker J, Honda S, Harada N, Balthazart J. Sexual partner preference requires a functional aromatase (cyp19) gene in male mice. Horm Behav 2002; 42: 158-171.
21. Kudwa AE, Boon WC, Simpson ER, Handa RJ, Rissman EF. Dietary phytoestrogens dampen female sexual behavior in mice with a disrupted aromatase enzyme gene. Behav Neurosci 2007; 121: 356-361.
22. Scordalakes EM, Shetty SJ, Rissman EF. Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase. J Comp Neurol 2002; 453: 336-344.
23. Friend KE, Chiou YK, Lopes MB, Laws ER Jr, Hughes KM, Shupnik MA. Estrogen receptor expression in human pituitary: Correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas. J Clin Endocrinol Metab 1994; 78: 1497-1504.
24. Greco B, Blasberg ME, Kosinski EC, Blaustein JD. Response of ERalpha-IR and ERbeta-IR cells in the forebrain of female rats to mating stimuli. Horm Behav 2003; 43: 444-453.
25. Kudwa AE, Gustafsson JA, Rissman EF. Estrogen receptor beta modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area. Endocrinology 2004; 145: 4500-4506.
26. Moffatt CA, Rissman EF, Shupnik MA, Blaustein JD. Induction of progestin receptors by estradiol in the forebrain of estrogen receptor-alpha gene-disrupted mice. J Neurosci 1998; 18: 9556-9563.
27. Franklin KBJ, Paxinos G. The Mouse Brain in Stereotaxic Coordinates. New York, NY: Academic Press, 1997.
28. Ogawa S, Chan J, Chester AE, Gustafsson JA, Korach KS, Pfaff DW. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Proc Natl Acad Sci USA 1999; 96: 12887-12892.
29. Temple JL, Scordalakes EM, Bodo C, Gustafsson JA, Rissman EF. Lack of functional estrogen receptor beta gene disrupts pubertal male sexual behavior. Horm Behav 2003; 44: 427-434.
30. Liposits Z, Kallo I, Coen CW, Paull WK, Flerko B. Ultrastructural analysis of estrogen receptor immunoreactive neurons in the medial preoptic area of the female rat brain. Histochemistry 1990; 93: 233-239.
31. Simerly RB, Carr AM, Zee MC, Lorang D. Ovarian steroid regulation of estrogen and progesterone receptor messenger ribonucleic acid in the anteroventral periventricular nucleus of the rat. J Neuroendocrinol 1996; 8: 45-56.
32. Yokosuka M, Okamura H, Hayashi S. Postnatal development and sex difference in neurons containing estrogen receptor-alpha immunoreactivity in the preoptic brain, the diencephalon, and the amygdala in the rat. J Comp Neurol 1997; 389: 81-93.
33. Clancy AN, Michael RP. Effects of testosterone and aromatase inhibition on estrogen receptor-like immunoreactivity in male rat brain. Neuroendocrinology 1994; 59: 552-560.
34. Kudwa AE, Bodo C, Gustafsson JA, Rissman EFA. previously uncharacterized role for estrogen receptor beta: Defeminization of male brain and behavior. Proc Natl Acad Sci USA 2005; 102: 4608-4612.
35. Toda K, Saibara T, Okada T, Onishi S, Shizuta Y 2001 A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19). J Endocrinol 2005; 168: 217-220.
36. Toda K, Okada T, Takeda K, Akira S, Saibara T, Shiraishi M, Onishi S, Shizuta Y. Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice. J Endocrinol 2001; 168: 455-463.