Mannose-resistant Proteus-like and P. mirabilis fimbriae have specific and additive roles in P. mirabilis urinary tract infections

FEMS Immunology and Medical Microbiology

Volumn 51, Issue 1, 2007, Pages 125-133

  Zunino, Pablo ^a,d   Sosa, Vanessa ^a   Schlapp, Geraldine ^a   Allen, Andrew G ^b   Preston, Andrew ^c   Maskell, Duncan J ^b  

^a INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d NONE   (Uruguay)

Author keywords

MR P fimbriae; PMF fimbriae; Proteus mirabilis

Indexed keywords

MANNOSE;

ARTICLE; BACTERIAL COLONIZATION; CELL ADHESION; EPITHELIUM CELL; FIMBRIA; GENE AMPLIFICATION; GENETIC ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEUS MIRABILIS; URINARY TRACT INFECTION;

ANIMALS; BACTERIAL ADHESION; BACTERIAL PROTEINS; FEMALE; FIMBRIAE, BACTERIAL; MANNOSE; MICE; PHENOTYPE; PROTEUS; PROTEUS MIRABILIS; URINARY TRACT INFECTIONS; VIRULENCE;

EID: 34548573717     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2007.00285.x     Document Type: Article

References (32)

1. Bahrani FK Mobley HLT (1994) Proteus mirabilis MR/P fimbrial operon: genetic organization, nucleotide sequence, and conditions for expression. J Bacteriol 176 : 3412 3419.
2. Bahrani FK, Massad G, Lockatell CV, Johnson DE, Russell RG, Warren JW Mobley HLT (1994) Construction of an MR/P fimbrial mutant of Proteus mirabilis: role in virulence in a mouse model of ascending urinary tract infection. Infect Immun 62 : 3363 3371.
3. Belas R, Erskine D Flaherty D (1991) Proteus mirabilis mutants defective in swarming cells differentiation and multicellular behaviour. J Bacteriol 173 : 6279 6288.
4. Bullock WO, Fernández JM Short JM (1987) XL1-Blue: a high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection. Biotechniques 5 : 376.
5. Coker C, Poore CA, Li X Mobley HLT (2000) Pathogenesis of Proteus mirabilis urinary tract infection. Microbes Infect 2 : 1497 1505.
6. Donnenberg MS Kaper JB (1991) Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive selection suicide vector. Infect Immun 59 : 4310 4317.
7. Jones BD, Lockatell CV, Johnson DE, Warren JW Mobley HLT (1990) Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection. Infect Immun 58 : 1120 1123.
8. Krieg NR Gerhardt P (1994) Solid, liquid/solid, and semisolid culture. Methods for General and Molecular Bacteriology (Gerhardt P, ed), pp. 216 223. American Society for Microbiology Press, Washington, DC.
9. Legnani-Fajardo C, Zunino P, Piccini C, Allen A Maskell D (1996) Defined mutants of Proteus mirabilis lacking flagella cause ascending urinary tract infection. Microb Pathog 21 : 395 405.
10. Locht C (1999) Molecular aspects of Bordetella pertussis pathogenesis. Int Microbiol 2 : 137 144.
11. Manoil C Beckwith J (1985) TnphoA: a transposon probe for protein export signals. Proc Natl Acad Sci USA 82 : 8129 8133.
12. Maskell DJ, Morrisey P Dougan G (1988) Cloning and nucleotide sequence of the aroA gene of Bordetella pertussis. J Bacteriol 170 : 2467 2471.
13. Massad G, Lockatell CV, Johnson DE Mobley HLT (1994) Proteus mirabilis fimbriae: construction of an isogenic pmfA mutant and analysis of virulence in a CBA mouse model of ascending urinary tract infection. Infect Immun 62 : 536 542.
14. Mobley HLT Chippendale GR (1990) Hemagglutinin, urease, and hemolysin production by Proteus mirabilis from clinical sources. J Infect Dis 161 : 525 530.
15. Neu HC (1992) Optimal characteristics of agents to treat uncomplicated urinary tract infections. Infections 20 : 266 271.
16. Old DC Adegbola RA (1982) Heamagglutinins and fimbriae of Morganella, Proteus and Providencia. J Med Microbiol 15 : 551 564.
17. Pellegrino R, Galvalisi U, Scavone P, Sosa V Zunino P (2003) Evaluation of Proteus mirabilis structural fimbrial proteins as antigens against urinary tract infections. FEMS Immunol Med Microbiol 36 : 103 110.
18. Reid G Sobel J (1987) Bacterial adherence in the pathogenesis of urinary tract infections: a review. Rev Infect Dis 9 : 470 487.
19. Rozalski A, Sidorczyk Z Kotelko K (1997) Potential virulence factors of Proteus bacilli. Microbiol Mol Biol Rev 61 : 65 89.
20. Sambrook J, Fritsch EF Maniatis T (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
21. Scavone P, Sosa V, Pellegrino R, Galvalisi U Zunino P (2004) Mucosal vaccination of mice with recombinant Proteus mirabilis structural fimbrial proteins. Microbes Infect 6 : 853 860.
22. Shih C Weinberg RA (1982) Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 29 : 161 169.
23. Simon R, Priefer U Puhler A (1983) A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram negative bacteria. Biotechnology 1 : 784 791.
24. Sosa V, Schlapp G Zunino P (2006) Proteus mirabilis isolates of different origins do not show correlation with virulence attributes and can colonize the urinary tract of mice. Microbiology 152 : 2149 2157.
25. Swihart KG Welch RA (1990) Cytotoxic activity of the Proteus hemolysin HpmA. Infect Immun 58 : 1861 1869.
26. Tolson DL, Harrison BA, Latta RK, Lee KK Altman E (1997) The expression of nonagglutinating fimbriae and its role in Proteus mirabilis adherence to epithelial cells. Can J Microbiol 43 : 709 717.
27. Towbin H, Staehelin T Gordon J (1979) Electrophoresis transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76 : 4350 4354.
28. Van Der Velden AWM, Baümler AJ, Tsolis REM Heffron F (1998) Multiple fimbrial adhesins are required for full virulence of Salmonella typhimurium in mice. Infect Immun 66 : 2803 2808.
29. Vieira J Messing J (1982) The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19 : 259 268.
30. Zunino P, Geymonat L, Allen AG, Legnani-Fajardo C Maskell DJ (2000) Virulence of a Proteus mirabilis ATF isogenic mutant in not impaired in a mouse model of ascending urinary tract infection. FEMS Immunol Med Microbiol 29 : 137 143.
31. Zunino P, Geymonat L, Allen AG, Preston A, Sosa V Maskell DJ (2001) New aspects of the role of MR/P fimbriae in Proteus mirabilis urinary tract infection. FEMS Immunol Med Microbiol 31 : 113 120.
32. Zunino P, Sosa V, Allen AG, Preston A, Schlapp G Maskell DJ (2003) Proteus mirabilis fimbriae (PMF) are important for both bladder and kidney colonisation in mice. Microbiology 149 : 3231 3237.