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Early examples of the preparation of 2a: (a) Stadler, P. A.; Nechvatal, A.; Frey A. J.; Eschenmoser, A. Helv. Chim. Acta 1957, 40, 1373-1409.
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Preparation of 2b: (a) Mesnard, D.; Miginiac, L. J. Organomet. Chem. 1990, 397, 127-137.
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0026549953
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A similar selectivity for the 2-bromo derivative: Hirama, M.; Fujiwara, K.; Shigematu, K.; Fukazawa, Y. J. Am. Chem. Soc. 1989, 111, 4120-4122.
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34548534079
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While the authors of ref 13 did not mention the preparation, TMSC≡ CMe has been synthesized by the methods
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While the authors of ref 13 did not mention the preparation, TMSC≡ CMe has been synthesized by the methods:
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0000705649
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34548539549
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See ref 6
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(c) See ref 6.
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Reactions with the propargylic copper reagents: (a) Lam, H. W.; Pattenden, G. Angew. Chem., Int. Ed. 2002, 41, 508-511.
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34548522193
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(d) See ref 7c.
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Although (1S)-14 is the direct substrate to give (1R)-16, synthesis of (1S)-14 by the asymmetric hydrolysis of the diacetate by PLE of several lots was unsuccessful in our hand. The hydrolysis with PLE: (a) Wang, Y.-F.; Chen, C-S.; Girdaukas, G.; Sih, C. J. J. Am. Chem. Soc. 1984, 106, 3695-3696.
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