Effects of continuous dexamethasone treatment on differentiation capabilities of bone marrow-derived mesenchymal cells

Bone

Volumn 41, Issue 4, 2007, Pages 575-583

  Oshina, Hidekazu ^a   Sotome, Shinichi ^a   Yoshii, Toshitaka ^a   Torigoe, Ichiro ^a   Sugata, Yumi ^a   Maehara, Hidetsugu ^a   Marukawa, Eriko ^a   Omura, Ken ^a   Shinomiya, Kenichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bone marrow derived mesenchymal cells; Dexamethasone; Multi lineage potential; Osteogenesis

Indexed keywords

DEXAMETHASONE; MESSENGER RNA; TRANSCRIPTION FACTOR SOX9;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINEAGE; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG EFFECT; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MONKEY; NONHUMAN; OSSIFICATION; OSTEOBLAST;

ADIPOGENESIS; ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CASPASE 3; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; COLONY-FORMING UNITS ASSAY; CYTOPHOTOMETRY; DEXAMETHASONE; FEMALE; HUMANS; MACACA; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOGENESIS;

EID: 34548537171     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.06.022     Document Type: Article

References (40)

1. Banwart J.C., Asher M.A., and Hassanein R.S. Iliac crest bone graft harvest donor site morbidity. A statistical evaluation. Spine 20 9 (1995) 1055-1060
2. Fernyhough J.C., Schimandle J.J., Weigel M.C., Edwards C.C., and Levine A.M. Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion. Spine 17 12 (1992) 1474-1480
3. Kurz L.T., Garfin S.R., and Booth Jr. R.E. Harvesting autogenous iliac bone grafts. A review of complications and techniques. Spine 14 12 (1989) 1324-1331
4. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 5411 (1999) 143-147
5. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 5309 (1997) 71-74
6. Vacanti V., Kong E., Suzuki G., Sato K., Canty J.M., and Lee T. Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture. J Cell Physiol 205 2 (2005) 194-201
7. Digirolamo C.M., Stokes D., Colter D., Phinney D.G., Class R., and Prockop D.J. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 107 2 (1999) 275-281
8. Haynesworth S.E., Goshima J., Goldberg V.M., and Caplan A.I. Characterization of cells with osteogenic potential from human marrow. Bone 13 1 (1992) 81-88
9. Jaiswal N., Haynesworth S.E., Caplan A.I., and Bruder S.P. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64 2 (1997) 295-312
10. Sekiya I., Colter D.C., and Prockop D.J. BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 284 2 (2001) 411-418
11. Sekiya I., Larson B.L., Vuoristo J.T., Reger R.L., and Prockop D.J. Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res 320 2 (2005) 269-276
12. Derfoul A., Perkins G.L., Hall D.J., and Tuan R.S. Glucocorticoids promote chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes. Stem Cells 24 6 (2006) 1487-1495
13. Indrawattana N., Chen G., Tadokoro M., Shann L.H., Ohgushi H., Tateishi T., et al. Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Biophys Res Commun 320 3 (2004) 914-919
14. Yokoyama A., Sekiya I., Miyazaki K., Ichinose S., Hata Y., and Muneta T. In vitro cartilage formation of composite of synovium-derived mesenchymal stem cells with collagen gel. Cell Tissue Res 322 (2005) 289-298
15. Tajima N., Sotome S., Marukawa E., Omura K., and Shinomiya K. A three-dimensional cell-loading system using autologous plasma loaded into a porous β-tricalcium-phosphate block promotes bone formation at extraskeletal sites in rats. Mater Sci Eng C 27 (2007) 625-632
16. Torigoe I, Sotome S, Tsuchiya A, Yoshii T, Takahashi M, Kawabata S, Shinomiya K. Novel cell seeding system into a porous scaffold using a modified low pressure method to enhance cell seeding efficiency and bone formation. Cell Transplant; in press.
17. Jiang Y., Jahagirdar B.N., Reinhardt R.L., Schwartz R.E., Keene C.D., Ortiz-Gonzalez X.R., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418 6893 (2002) 41-49
18. Toma C., Pittenger M.F., Cahill K.S., Byrne B.J., and Kessler P.D. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105 1 (2002) 93-98
19. Gregory C.A., Prockop D.J., and Spees J.L. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp Cell Res 306 2 (2005) 330-335
20. Koc O.N., Gerson S.L., Cooper B.W., Dyhouse S.M., Haynesworth S.E., Caplan A.I., et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 18 2 (2000) 307-316
21. Koc O.N., Day J., Nieder M., Gerson S.L., Lazarus H.M., and Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 30 4 (2002) 215-222
22. Horwitz E.M., Prockop D.J., Gordon P.L., Koo W.W., Fitzpatrick L.A., Neel M.D., et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 97 5 (2001) 1227-1231
23. Horwitz E.M., Prockop D.J., Fitzpatrick L.A., Koo W.W., Gordon P.L., Neel M., et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5 3 (1999) 309-313
24. Kawate K., Yajima H., Ohgushi H., Kotobuki N., Sugimoto K., Ohmura T., et al. Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula. Artif Organs 30 12 (2006) 960-962
25. Morishita T., Honoki K., Ohgushi H., Kotobuki N., Matsushima A., and Takakura Y. Tissue engineering approach to the treatment of bone tumors: three cases of cultured bone grafts derived from patients' mesenchymal stem cells. Artif Organs 30 2 (2006) 115-118
26. Yoshikawa T., Ohgushi H., Ichijima K., and Takakura Y. Bone regeneration by grafting of cultured human bone. Tissue Eng 10 5-6 (2004) 688-698
27. Takakura Y., Tanaka Y., Kumai T., Sugimoto K., and Ohgushi H. Ankle arthroplasty using three generations of metal and ceramic prostheses. Clin Orthop Relat Res 424 (2004) 130-136
28. Cheng S.L., Yang J.W., Rifas L., Zhang S.F., and Avioli L.V. Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone. Endocrinology 134 1 (1994) 277-286
29. Diefenderfer D.L., Osyczka A.M., Garino J.P., and Leboy P.S. Regulation of BMP-induced transcription in cultured human bone marrow stromal cells. J Bone Joint Surg Am 85-A Suppl 3 (2003) 19-28
30. Liu Y., Titus L., Barghouthi M., Viggeswarapu M., Hair G., and Boden S.D. Glucocorticoid regulation of human BMP-6 transcription. Bone 35 3 (2004) 673-681
31. Friedman M.S., Long M.W., and Hankenson K.D. Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J Cell Biochem 98 3 (2006) 538-554
32. Boden S.D., Hair G., Titus L., Racine M., Mccuaig K., Wozeny J.M., et al. Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6. Endocrinology 138 7 (1997) 2820-2828
33. zur Nieden N.I., Kempka G., Rancourt D.E., and Ahr H.J. Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. BMC Dev Biol. 5 (Jan 26 2005) 1
34. Zaragosi L.E., Ailhaud G., and Dani C. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 24 (2006) 2412-2419
35. Spreafico A., Frediani B., Capperucci C., Leonini A., Gambera D., Ferrata P., et al. Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis. J Cell Biochem 98 4 (2006) 1007-1020
36. Gu G., Hentunen T.A., Nars M., Harkonen P.L., and Vaananen H.K. Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis. Apoptosis 10 3 (2005) 583-595
37. Liu Y., Porta A., Peng X., Gengaro K., Cunningham E.B., Li H., et al. Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28 k. J Bone Miner Res 19 3 (2004) 479-490
38. Bellows C.G., Heersche J.N.M., and Aubin J.E. Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of dexamethasone. Dev Biol 140 (1990) 132-138
39. Bellows C.G., Heersche J.N.M., and Aubin J.E. Effects of dexamethasone on expression and maintenance of cartilage in serum-containing cultures of calvaria cells. Cell Tissue Res 256 (1989) 145-151
40. Bellows C.G., Wang Y.H., Heersche J.N.M., and Aubin J.E. 1,25-Dihydroxyvitamin D3 stimulates adipocyte differentiation in cultures of fetal rat calvaria cells: comparison with the effects of dexamethasone. Endocrinology 134 5 (1994) 2221-2229