Increased cyclooxygenase expression and thymine dimer formation after repeated exposures of humans to low doses of solar simulated radiation

Experimental Dermatology

Volumn 16, Issue 10, 2007, Pages 837-843

  Narbutt, Joanna ^a   Lesiak, Aleksandra ^a   Jochymski, Cezary ^b   Kozlowski, Wojciech ^b   Sysa jedrzejowska, Anna ^a   Norval, Mary ^c  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b MILITARY INSTITUTE OF MEDICINE   (Poland)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cyclooxygenase 1 and 2; Photoadaptation; Photoprotection; Solar simulated radiation thymine dimers

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; THYMINE;

ADULT; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ERYTHEMA; FEMALE; HUMAN; HUMAN TISSUE; MALE; NORMAL HUMAN; PHOTOACCLIMATIZATION; PROTEIN EXPRESSION; RADIATION EXPOSURE; SIMULATION; SKIN BIOPSY; SKIN CARCINOGENESIS; SKIN PIGMENTATION; SKIN PROTECTION; SOLAR RADIATION; SUNLIGHT PROTECTION; ULTRAVIOLET B RADIATION;

ADAPTATION, PHYSIOLOGICAL; ADULT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, RADIATION; ERYTHEMA; FEMALE; HUMANS; KERATINOCYTES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRIMIDINE DIMERS; SKIN; SKIN PIGMENTATION; SUNLIGHT; ULTRAVIOLET RAYS;

EID: 34548512499     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2007.00598.x     Document Type: Article

References (34)

1. Ullrich S E. Mechanisms underlying UV-induced immune suppression. Mutat Res 2005: 571: 185-205.
2. Schwarz T. Mechanisms of UV-induced immunosuppression. Keio J Med 2005: 54: 165-171.
3. Vink A A, Shreedhar V, Roza L, Krutmann J, Kripke M L. Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity. J Photochem Photobiol B 1998: 44: 107-111.
4. Young A R, Chadwick C A, Harrison G I, Hawk J L, Nikaido O, Potten C S. The in situ repair kinetics of epidermal thymine dimers and 6-4 photproducts in human skin types I and II. J Invest Dermatol 1996: 106: 1307-1313.
5. Vink A A, Strickland F M, Bucana P A et al. Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice. J Exp Med 1996: 183: 1491-1500.
6. Hart P H, Townley S L, Grimbaldeston M A, Khalil Z, Finlay-Jones J J. Mast cells, neuropeptides, histamine, and prostaglandins in UV-induced systemic immunosuppression. Methods 2002: 28: 79-89.
7. Jans J, Schul W, Sert Y G et al. Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol 2005: 15: 105-115.
8. Walterscheid J P, Ullrich S E, Ngiem D X. Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J Exp Med 2002: 195: 171-179.
9. Pei Y, Barber L A, Murphy R C et al. Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. J Immunol 1998: 161: 1954-1961.
10. Tripp C S, Blomme E A, Chinn K S, Hardy M M, LaCelle P, Pentland A P. Epidermal COX-2 induction following ultraviolet irradiation: Suggested mechanism for the role of COX-2 inhibition in photoprotection. J Invest Dermatol 2003: 121: 853-861.
11. Muller-Decker K, Kopp-Schneider A, Marks F, Seibert K, Fustenberger G. Localization of prostaglandin H synthase isozymes in murine epidermal tumors. Suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. Mol Carcinogenesis 1998: 23: 36-44.
12. Pentland A P, Schoggins J W, Scott G A, Khan K N, Han R. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis 1999: 20: 1939-1944.
13. Athar M, An K P, Morel K D et al. Ultraviolet B (UVB)-induced COX-2 expression in murine skin: An immunohistochemical study. Biochem Biophys Res Comm 2001: 280: 1042-1047.
14. An K P, Athar M, Tang X et al. Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: Implications for therapeutic approaches. Photochem Photobiol 2002: 76: 73-80.
15. Smith W L, Garavito R M, DeWitt D L. Prostaglandin endoperoxidase H synthase (cyclooxygenases-1 and -2). J Biol Chem 1996: 271: 33157-33160.
16. Pentland A P, Scott G, VanBuskirk J, Tanck C, LaRossa G, Brouxhon S. Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors. Cancer Res 2004: 64: 5587-5591.
17. + epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci USA 1992: 89: 8497-8501.
18. Kelly D A, Walker S L, McGregor J M, Young A R. A single exposure of solar simulated radiation suppresses contact hypersensitivity responses both locally and systemically in humans: Quantitative studies with high frequency ultrasound. J Photochem Photobiol B 1998: 44: 130-142.
19. Wolf P, Hoffmann C, Quehenberger F, Grinschgl S, Kerl H. Immune protection factors of chemical sunscreens measured in the local contact hypersensitivity model in humans. J Invest Dermatol 2003: 121: 1080-1087.
20. Stoebner PE, Rahmoun M, Ferrand C, Meunier L, Yssel H, Pene J. A single sub-erythematosus exposure of solar-simulated radiation on the elicitation phase of contact hypersensitivity induces IL-10-producing T-regulatory cells in human skin. Exp Dermatol 2006: 15: 615-624.
21. Narbutt J, Lesiak A, Skibinska M et al. Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation. Photochem Photobiol Sci 2005: 4: 517-522.
22. Diffey BL. Sources and measurement of ultraviolet radiation. Methods 2002: 28: 4-13.
23. Sheehan J M, Potten C S, Young A R. Tanning in human types II and III offers modest photoprotection against erythema. Photochem Photobiol 1998: 68: 588-592.
24. Fitzpatrick T B. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988: 124: 869-871.
25. Narbutt J, Lesiak A, Sysa-Jedrzejowska A et al. Repeated low dose UVB exposures of humans induce limited photoprotection against the immune effects of erythema UVB radiation. Br J Dermatol 2007: 156: 539-547.
26. Bech-Thomsen N, Ravnborg L, Wulf H C. A quantitative study of the melanogenic effect of multiple suberytemal doses of different ultraviolet radiation sources. Photodermatol Photoimmunol Photomed 1994: 10: 53-56.
27. Barnetson R S, Ooi T K, Zhuang L et al. [Nle4-D-phe7]-α-melanocyte-stimulating hormone significantly increased pigmentation and decreased UV damage in fair-skinned Caucasian volunteers. J Invest Dermatol 2006: 126: 1869-1878.
28. Kollias N, Stamatas G N, Youn J I. Suppression of UVB-induced cutaneous erythema by a previous UVB exposure. Photochem Photobiol 2001: 74: 471-478.
29. Al Mahroos M, Yaar M, Phillips T J, Bhawan J, Gilchrest B A. Effect of sunscreen application of UV-induced thymine dimers. Arch Dermatol 2002: 138: 1480-1485.
30. Kuchel J M, Barnetson R S, Halliday G M. Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans. Photochem Photobiol Sci 2005: 4: 577-582.
31. Young A R, Chadwick C A, Harrison G I, Nikaido O, Ramsden J, Potten C S. The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. J Invest Dermatol 1998: 111: 982-989.
32. Stege H, Roza L, Vink A A et al. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc Natl Acad Sci USA 2000: 97: 1790-1795.
33. Eller M S, Ostrom K, Gilchrest B A. DNA damage enhances melanogenesis. Proc Natl Acad Sci USA 1996: 93: 1087-1092.
34. Sheehan J M, Cragg N, Chadwick C A, Potten C S, Young A R. Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV. J Invest Dermatol 2002: 118: 825-829.