-
1
-
-
0018639190
-
Activation of inactive plasma renin by plasma and tissue kallikreins
-
Derkx FHM, Tan-Tjiong HL, Man in't Veld AJ, et al.: Activation of inactive plasma renin by plasma and tissue kallikreins. Clin Sci (Lond) 1979, 57:351-357.
-
(1979)
Clin Sci (Lond)
, vol.57
, pp. 351-357
-
-
Derkx, F.H.M.1
Tan-Tjiong, H.L.2
Man in't Veld, A.J.3
-
2
-
-
0024495446
-
Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy
-
Danser AHJ, van den Dorpel MA, Deinum J, et al.: Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy. J Clin Endocrinol Metab 1989, 68:160-167.
-
(1989)
J Clin Endocrinol Metab
, vol.68
, pp. 160-167
-
-
Danser, A.H.J.1
van den Dorpel, M.A.2
Deinum, J.3
-
3
-
-
0025794059
-
Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
-
Alderman MH, Madhavan S, Ooi WL, et al.: Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. N Engl J Med 1991, 324:1098-104.
-
(1991)
N Engl J Med
, vol.324
, pp. 1098-1104
-
-
Alderman, M.H.1
Madhavan, S.2
Ooi, W.L.3
-
4
-
-
0023264333
-
Active immunization against renin in normotensive marmoset
-
Michel JB, Guettier C, Philippe M, et al.: Active immunization against renin in normotensive marmoset. Proc Natl Acad Sci U S A 1987, 84:4346-4350.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 4346-4350
-
-
Michel, J.B.1
Guettier, C.2
Philippe, M.3
-
5
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril
-
Nussberger J, Wuerzner G, Jensen C, Brunner HR: Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril. Hypertension 2002, 39:e1-e8.
-
(2002)
Hypertension
, vol.39
-
-
Nussberger, J.1
Wuerzner, G.2
Jensen, C.3
Brunner, H.R.4
-
6
-
-
0024368885
-
Pharmacological investigations of a new renin inhibitor in normal sodium-unrestricted volunteers
-
de Gasparo M, Cumin F, Nussberger J, et al.: Pharmacological investigations of a new renin inhibitor in normal sodium-unrestricted volunteers. Br J Clin Pharmacol 1989, 27:587-596.
-
(1989)
Br J Clin Pharmacol
, vol.27
, pp. 587-596
-
-
de Gasparo, M.1
Cumin, F.2
Nussberger, J.3
-
7
-
-
0029017662
-
Clinical pharmacokinetics and efficacy of renin inhibitors
-
Rongen GA, Lenders JWM, Smits P, Thien T: Clinical pharmacokinetics and efficacy of renin inhibitors. Clin Pharmacokinet 1995, 29:6-14.
-
(1995)
Clin Pharmacokinet
, vol.29
, pp. 6-14
-
-
Rongen, G.A.1
Lenders, J.W.M.2
Smits, P.3
Thien, T.4
-
8
-
-
0027246493
-
Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects
-
Kleinbloesem CH, Weber C, Fahrner E et al.: Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects. Clin Pharmacol Ther 1993, 53:585-592.
-
(1993)
Clin Pharmacol Ther
, vol.53
, pp. 585-592
-
-
Kleinbloesem, C.H.1
Weber, C.2
Fahrner, E.3
-
9
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Maibaum J, Rahuel J, et al.: Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003, 308:698-705.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
-
10
-
-
14044271546
-
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
-
Wood JM, Schnell CR, Cumin F, et al.: Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens 2005, 23:417-426.
-
(2005)
J Hypertens
, vol.23
, pp. 417-426
-
-
Wood, J.M.1
Schnell, C.R.2
Cumin, F.3
-
11
-
-
33846160571
-
Aspartic proteases in drug discovery
-
Eder J, Hommel U, Cumin F, et al.: Aspartic proteases in drug discovery. Curr Pharm Des 2007, 13:271-285.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 271-285
-
-
Eder, J.1
Hommel, U.2
Cumin, F.3
-
12
-
-
4744348177
-
Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects
-
Dieterle W, Corynen S, Mann J: Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects. Br J Clin Pharmacol 2004, 58:433-436.
-
(2004)
Br J Clin Pharmacol
, vol.58
, pp. 433-436
-
-
Dieterle, W.1
Corynen, S.2
Mann, J.3
-
13
-
-
25444454353
-
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
-
Pilz B, Shagdarsuren E, Wellner M, et al.: Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 2005, 46:569-576.
-
(2005)
Hypertension
, vol.46
, pp. 569-576
-
-
Pilz, B.1
Shagdarsuren, E.2
Wellner, M.3
-
14
-
-
0347479295
-
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
-
Stanton A, Jensen C, Nussberger J, O'Brien E: Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 2003, 42:1137-1143.
-
(2003)
Hypertension
, vol.42
, pp. 1137-1143
-
-
Stanton, A.1
Jensen, C.2
Nussberger, J.3
O'Brien, E.4
-
15
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schmieder RE, Lins RL, et al.: Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005, 111:1012-1018.
-
(2005)
Circulation
, vol.111
, pp. 1012-1018
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
-
16
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
Villamil A, Chrysant SG, Calhoun D, et al.: Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007, 25:217-226.
-
(2007)
J Hypertens
, vol.25
, pp. 217-226
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
17
-
-
33846421005
-
Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker
-
O'Brien E, Barton J, Nussberger J, et al.: Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension 2007, 49:276-284.
-
(2007)
Hypertension
, vol.49
, pp. 276-284
-
-
O'Brien, E.1
Barton, J.2
Nussberger, J.3
-
18
-
-
85190688115
-
-
Azizi M, Menard J, Bissery A, et al.: Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. Am Soc Nephro12004, 15:3126-3133.
-
Azizi M, Menard J, Bissery A, et al.: Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. Am Soc Nephro12004, 15:3126-3133.
-
-
-
-
19
-
-
33845785350
-
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
-
Pool JL, Schmieder RE, Azizi M, et al.: Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens 2007, 20:11-20.
-
(2007)
Am J Hypertens
, vol.20
, pp. 11-20
-
-
Pool, J.L.1
Schmieder, R.E.2
Azizi, M.3
-
20
-
-
34247867955
-
Direct renin inhibition with aliskiren in obese patients with arterial hypertension
-
Jordan J, Engeli S, Boye SW, et al.: Direct renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension 2007, 49:1047-1055.
-
(2007)
Hypertension
, vol.49
, pp. 1047-1055
-
-
Jordan, J.1
Engeli, S.2
Boye, S.W.3
|