Tacrolimus (FK506) reduces hippocampal damage but fails to prevent learning and memory deficits after transient, global cerebral ischemia in rats

Pharmacology Biochemistry and Behavior

Volumn 88, Issue 1, 2007, Pages 28-38

  Benetoli, Arcelio ^a   Dutra, Aline Mara ^a   Paganelli, Ricardo Alexandre ^a   Senda, Dalton Makoto ^a   Franzin, Simone ^a   Milani, Humberto ^a  

^a Universidade Estadual de Maringa Centro de Ciencias da Saude Faculdade de Medicina   (Brazil)

Author keywords

Aversive radial maze; FK506; Global cerebral ischemia; Learning and memory; Neurodegeneration; Neuroprotection

Indexed keywords

TACROLIMUS;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HIPPOCAMPUS; LEARNING DISORDER; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; HIPPOCAMPUS; IMMUNOSUPPRESSIVE AGENTS; ISCHEMIC ATTACK, TRANSIENT; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMORY DISORDERS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; TACROLIMUS;

RATTUS;

EID: 34548504306     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2007.07.001     Document Type: Article

References (46)

1. Aronowski J., Samways E., Strong R., Rhoades H.M., and Grotta J.C. An alternative method for the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats: Analysis of behavioral deficits. J Cereb Blood Flow Metab 16 (1996) 705-713
2. Bachevalier J., and Meunier M. Cerebral Ischemia: are the memory deficits associated with hippocampal cell loss?. Hippocampus 66 (1999) 553-560
3. Bennett P.C., Schmidt L., Lawen A., Moutsoulas P., and Ng K.T. Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick. Brain Res 927 (2002) 180-194
4. Benetoli A., Paganelli R.A., Giordani F., Lima K.C.M., Favero-Filho L.A., and Milani H. Effect of tacrolimus (FK506) on ischemia-induced brain damage and memory dysfunction in rats. Pharmacol Biochem Behav 77 (2004) 607-615
5. Busto R., Dietrich W.D., Globus M.Y.-T., Valdes I., Scheinberg P., and Ginsberg M.D. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7 (1987) 729-738
6. Busto R., Dietrich D.W., Globus M.Y.-T., and Ginsberg M.D. The importance of brain Temperature in cerebral ischemic injury. Stroke 20 8 (1989) 113-114
7. Colbourne F., and Corbett D. Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection. J Neurosci 15 11 (1995) 7250-7260
8. Cummings J.L., Tomiyasu U., Read S., and Benson D.F. Amnesia with hippocampal lesions after cardiopulmonary arrest. Neurology 34 (1984) 679-681
9. Dale R.H. Spatial and temporal response patterns on the eight-arm radial maze. Physiol Behav 36 4 (1986) 787-790
10. Dawson T.M., Steiner J.P., Dawson V.L., Dinerman J.L., Uhl G.R., and Snyder S.H. Immunossupressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci USA 90 (1993) 9808-9812
11. Drake M., Friberg H., Boris-Moller F., Sakata K., and Wieloch T. The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. Acta Physiol Scand 158 (1996) 155-159
12. Dudchenko P.A. An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev 28 (2004) 699-709
13. Earnest M.P., Yarnell P.T., Merril S.L., and Knapp G.L. Long-term survival and neurologic status after resuscitation from out-of-hospital cardiac arrest. Neurol 30 (1980) 1298-1302
14. Furuichi Y., Katsuta K., Maeda M., Ueyama N., Moriguchi A., Matsuoka N., et al. Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy. Brain Res 965 (2003) 137-145
15. Furuichi Y., Maeda M., Moriguchi A., Sawamoto T., Kawamura A., Matsuoka N., et al. Tacrolimus, a potential neuroprotective agent, ameliorates ischemic brain damage and neurologic deficits after focal cerebral ischemia in nonhuman primates. J Cereb Blood Flow Metab 23 10 (2003) 1183-1194
16. Furuichi Y., Noto T., Li J.-Y., Oku T., Ishiye M., Moriguchi A., et al. Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats. Brain Res 1014 (2004) 120-130
17. Ginsberg M.D., Sternau L.L., Globus M.Y.-T., Dietrich D.W., and Busto R. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev 4 (1992) 189-225
18. Giordani F., Benetoli A., Favero-Filho L.A., Lima K.C.M., Cestari J.L., and Milani H. Tacrolimus (FK506) reduces ischemia-induced hippocampal damage in rats: a 7- and 30-day study. Braz J Med Biol Res 36 4 (2003) 495-502
19. Green E.J., Dietrich W.D., Van Dijk F., Busto R., Markgraf C.G., McCabe P.M., et al. Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats. Brain Res 580 (1992) 197-204
20. Hamilton G.S., and Steiner J.P. Neuroimmunophilin ligands as novel therapeutics for the treatment of degenerative disorders of the nervous system. Curr Pharm Des 3 (1997) 405-428
21. Hodges H. Maze procedures: the radial-arm and water maze compared. Cogn Brain Res 3 (1996) 167-181
22. Ide T., Morikawa E., and Kirino T. An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil. Neurosci Lett 204 (1996) 157-160
23. Ikegami S., and Inokuchi K. Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction. Neurosci 98 4 (2000) 637-646
24. Ishimaru H., Takahashi A., Ikarashi Y., and Muruyama Y. Pentobarbital protects against CA1 pyramidal cell death but not dysfunction of hippocampal cholinergic neurons following transient ischemia. Brain Res 673 (1995) 112-118
25. Kaminska B., Gaweda-Walerych K., and Zawadzka M. Molecular mechanisms of neuroprotective action of immunosuppressants - facts and hypotheses. J Cell Mol Med 8 1 (2004) 45-58
26. Katsuta K., Umemura K., Ueyama N., and Matsuoka N. Pharmacological evidence for a correlation between hippocampal CA1 cell damage and hyperlocomotion following global cerebral ischemia in gerbils. Eur J Pharmacol 467 (2003) 103-109
27. Lim C., Alexander M.P., LaFleche G., Schnyer D.M., and Verfaellie M. The neurological and cognitive sequelae of cardiac arrest. Neurology 63 10 (2004) 1774-1778
28. Longstreth Jr. W.T., Inui T.S., Cobb L.A., and Copass M.K. Neurologic recovery after out-of-hospital cardiac arrest. Ann Intern Med 98 (1983) 588-592
29. Macleod M.R., O'Collins T., Horky L.L., Howells D.W., and Donnan G.A. Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. J Cereb Blood Flow Metab 25 6 (2005) 713-721 [Jun]
30. Nito C., Kamiya T., Ueda M., Arii T., and Katayama Y. Mild hypothermia enhances the neuroprotective effects of FK506 and expands its therapeutic window following transient focal ischemia in rats. Brain Res 1008 (2004) 179-185
31. Nunn J.A., Le Peillet E., Netto C.A., Hodges H., Gray J.A., and Meldrum B.S. Global ischaemia: hippocampal pathology and spatial deficits in the water maze. Behav Brain Res 62 (1994) 41-54
32. Paganelli R.A., Benetolli A., Lima K.C.M., Cestari Junior L.A., Favero-Filho L.A., and Milani H. A novel version of the 8-arm radial maze: effects of cerebral ischemia on learning and memory. J Neurosci Methods 132 (2004) 9-18
33. Paganelli R.A., Benetoli A., and Milani H. Sustained neuroprotection and facilitation of behavioral recovery by the Ginkgo biloba extract, EGb 761, after transient forebrain ischemia in rats. Behav Brain Res 174 1 (2006) 70-77 [Nov 1]
34. Peskine A., Picq C., and Pradat-Diehl P. Cerebral anoxia and disability. Brain Inj 18 12 (2004) 1243-1254
35. Petito C.K., Feldmann E., Pulsinelli W.A., and Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 37 (1987) 1281-1286
36. Pulsinelli W.A., and Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10 3 (1979) 267-272
37. Pulsinelli W.A., and Buchan A.M. The four-vessel cocclusion rat model method for complete occlusion of vertebral arteries and control of collateral circulation. Stroke 19 7 (1988) 913-914
38. Roullet P., and Lassalle J.M. Radial maze learning using exclusively distant visual cues reveals learners and nonlearners among inbred mouse strains. Physiol Behav 58 6 (1995) 1189-1195
39. Seif el Nasr M., Nuglish J., and Krieglstein J. Prevention of ischemia-induced cerebral hypothermia by controlling the environmental temperature. J Pharmacol Methods 27 (1992) 23-26
40. Sharkey J., Crawford J.H., Butcher S.P., and Marston H.M. Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. Stroke 27 (1996) 2282-2286
41. Sharkey J., and Butcher S.P. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature 371 (1994) 336-339
42. STAIR. S.T.A.I.R, recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30 (1999) 2752-2758
43. Tokime T., Nozaki K., and Kikuchi H. Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. Neurosci Lett 206 (1996) 81-84
44. Volpe B.T., and Hirst W. The characterization of an amnesic syndrome following hypoxic ischemic injury. Arch Neurol 40 (1983) 436-440
45. Yagita Y., Kitagawa K., Matsushita K., Taguchi A., Mabuchi T., Ohtsuki T., et al. Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. Life Sci 59 19 (1996) 1643-1650
46. Zola-Morgan S., Squire L.R., and Amaral D.G. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the Hippocampus. J Neurosci 6 (1986) 2950-2967