The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people

Molecular Medicine

Volumn 13, Issue 7-8, 2007, Pages 388-395

  Giacconi, Robertina ^a   Muti, Elisa ^a   Malavolta, Marco ^a   Cipriano, Catia ^a   Costarelli, Laura ^a   Bernardini, Gianni ^a   Gasparini, Nazzarena ^a   Mariani, Erminia ^b,c   Saba, Vittorio ^a   Boccoli, Gianfranco ^a   Mocchegiani, Eugenio ^a  

^a INRCA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD56 ANTIGEN; COPPER; IRON; MAGNESIUM; METAL; METALLOTHIONEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRACE ELEMENT; ZINC;

AGED; AGING; ATHEROSCLEROSIS; CAROTID ARTERY OBSTRUCTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; FEMALE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MINERAL BALANCE; NATURAL KILLER CELL; PRIORITY JOURNAL; RISK FACTOR; STROKE; TRANSIENT ISCHEMIC ATTACK; ZINC DEFICIENCY;

AGED; AGED, 80 AND OVER; CAROTID STENOSIS; CHEMOKINE CCL2; CHEMOKINES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GENE FREQUENCY; HUMANS; INFLAMMATION; KILLER CELLS, NATURAL; MALE; METALLOTHIONEIN; METALS; POLYMORPHISM, GENETIC; RANTES;

EID: 34548496933     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2007-00045.Giacconi     Document Type: Conference Paper

References (54)

1. Watanabe T, Yasunari K, Nakamura M, Maeda K. (2006) Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients. J. Hum. Hypertens. 20:336-40.
2. Radak D, Cvetkovic Z, Tasic N, Petrovic B, Lackovic V, Djordjevic-Denic G. (2004) The content of copper and zinc in human ulcerated carotid plaque. Srp. Arh. Celok. Lek. 132:80-4.
3. Rostan EF, DeBuys HV, Madey DL, Pinnell SR. (2002) Evidence supporting zinc as an important antioxidant for skin. Int. J. Dermatol. 41:606-11.
4. Meerarani P, Ramadass P, Toborek M, Bauer HC, Bauer H, Hennig B. (2000) Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Am. J. Clin. Nutr. 71:81-7.
5. Faure P, Benhamou PY, Perard A, Halimi S, Roussel AM. (1995) Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur. J. Clin. Nutr. 49:282 -288 .
6. Reiterer G et al. (2005) Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. J. Nutr. 13:2114-8.
7. Kurabayashi M. (2005) Role of magnesium in cardiac metabolism Clin. Calcium 15:77-83.
8. Mielcarz G, Howard AN, Mielcarz B, Williams NR, Rajput-Williams J, Nigdigar SV, Stone DL. (2001) Leucocyte copper, a marker of copper body status is low in coronary artery disease. J. Trace Elem. Med. Biol. 15:31-5.
9. Ueshima K. (2005) Magnesium and ischemic heart disease: a review of epidemiological, experimental, and clinical evidences. Magnes. Res. 18:275-84.
10. Vlad M, Caseanu E, Uza G, Petrescu M. (1994) Concentration of copper, zinc, chromium, iron and nickel in the abdominal aorta of patients deceased with coronary heart disease J. Trace Elem. Electrolytes Health Dis. 8:111-4.
11. Paolisso G, Esposito R, D'Alessio MA, Barbieri M. (1999) Primary and secondary prevention of atherosclerosis: is there a role for antioxidants? Diabetes Metab. 25:298-306.
12. Lee DH, Folsom AR, Jacobs DR Jr. (2005) Iron, zinc, and alcohol consumption and mortality from cardiovascular diseases: the Iowa Women's Health Study. Am. J. Clin. Nutr. 81:787-91.
13. Palmiter RD. (1998) The elusive function of metallothioneins. Proc. Natl. Acad. Sci. U. S. A. 95:8428-30.
14. Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Tesei S, Malavolta M. (2006) Nutrient-gene interaction in ageing and successful ageing: a single nutrient (zinc) and some target genes related to inflammatory/immune response. Mech. Ageing Dev. 127:517-25.
15. Giacconi R et al. (2004) The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing. Exp. Gerontol. 39:621-8.
16. Mocchegiani E et al. (2002) MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans. Exp. Gerontol. 37:349-57.
17. Cipriano C et al. (2005) The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases. Int. J. Immunogenet. 32:13-18.
18. Bruunsgaard H, Pedersen AN, Schroll M, Skinhoj P, Pedersen BK. (2001) Decreased natural killer cell activity is associated with atherosclerosis in elderly humans Exp. Gerontol. 37:127-36.
19. Jonasson L, Backteman K, Ernerudh J. (2005) Loss of natural killer cell activity in patients with coronary artery disease. Atherosclerosis 183:316-21.
20. Sheikine Y, Hansson GK. (2004) Chemokines and atherosclerosis. Ann. Med. 36:98-118.
21. Boisvert WA. (2004) Modulation of atherogenesis by chemokines. Trends Cardiovasc. Med. 14:161-5.
22. Schober A et al. (2002) Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation 106:1523-29.
23. Wang J et al.(2006). Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation 113:544-54.
24. Wold LE et al. (2006) Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. Free Radic. Biol. Med. 40:1419-29.
25. Trendelenburg G et al. (2002) Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J. Neurosci. 2002; 22:5879-88.
26. Giacconi R et al. (2005) Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc. Biogerontology 6:407-13.
27. Hellings WE, Ackerstaff RG, Pasterkamp G, De Vries JP, Moll FL. (2006) The carotid atherosclerotic plaque and microembolisation during carotid stenting. J. Cardiovasc. Surg. 47:115-26
28. Mariani E, Cattini L, Neri S, Malavolta M, Mocchegiani E, Ravaglia G, Facchini A. (2006) Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status. Biogerontology 7:449-59.
29. Burdette SC, Walkup GK, Spingler B, Tsien RY, Lippard SJ. (2001) Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution. J. Am. Chem. Soc. 123:7831-41.
30. Malavolta M et al. (2006) Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: relationship with metallothioneins. Cytometry A. 69:1043-53.
31. Yurkow EJ, Makhijani PR. (1998) Flow cytometric determination of metallothionein levels in human peripheral blood lymphocytes: utility in environmental exposure assessment. J. Toxicol. Environ. Health A. 54:445-57.
32. Giacconi R et al. (2006) CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins. Int. J. Cardiol. Nov. 10 [Epub ahead of print].
33. Giacconi R et al. (2006) Involvement of -308 TNF-alpha and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients. Biogerontology 7 :347-56.
34. Prasad AS, Bao B, Beck FW, Kucuk O, Sarkar FH. (2004) Antioxidant effect of zinc in humans. Free Radic. Biol. Med. 37:1182-90.
35. Chen XL, Zhang Q, Zhao R, Medford RM. (2004) Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase. Am. J. Physiol Heart Circ Physiol. 286:H1001-7.
36. Larsson PT, Hallerstam S, Rosfors S, Wallen NH. (2005) Circulating markers of inflammation are related to carotid artery atherosclerosis Int Angiol. 24:43-51.
37. Profumo E et al. (2007) Intracellular expression of cytokines in peripheral blood from patients with atherosclerosis before and after carotid endarterectomy. Atherosclerosis 191(2):340-7.
38. Lee SD et al. (2006) Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron. Clin. Chim. Acta. 370:50-6.
39. Gosling Jet al. (1999) MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein J. Clin. Invest. 103:773-8.
40. Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ. (1998) Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell. 2:275-81.
41. Kissela B, Air E. (2006) Diabetes: impact on stroke risk and poststroke recovery. Semin. Neurol. 26:100-7.
42. Egashira K. (2003) Molecular mechanisms mediating inflammation in vascular disease: special reference to monocyte chemoattractant protein-1. Hypertension 41:834-41.
43. Ohtani K et al. (2004) Antimonocyte chemoattractant protein-1 gene therapy reduces experimental in-stent restenosis in hypercholesterolemic rabbits and monkeys. Gene Ther. 11:1273-82.
44. Kobusiak-Prokopowicz M, Orzeszko J, Mazur G, Mysiak A, Orda A, Mazurek W. (2005) Kinetics of chemokines in acute myocardial infarction. Kardiol. Pol. 62:301-16.
45. Arakelyan A, Petrkova J, Hermanova Z, Boyajyan A, Lukl J, Petrek M. (2005) Serum levels of the MCP-1 chemokine in patients with ischemic stroke and myocardial infarction. Mediators Inflamm. 3:175-9.
46. Martinovic I et al. (2005) Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease. Circ. J. 69:1484-9.
47. McCabe DJ et al. (2005) Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. J. Neurol. Neurosurg. Psychiatr 76:1249-54.
48. Turaj W, Slowik A, Dziedzic T, Pulyk R, Adamski M, Strojny J, Szczudlik A. (2006) Increased plasma fibrinogen predicts one-year mortality in patients with acute ischemic stroke. J. Neurol. Sci. 246:13-9.
49. Cipriano C et al. (2006) Polymorphisms in MT1A gene coding region are associated with longevity in Italian Central female population. Biogerontology 7:357-65.
50. Hamilton IM, Gilmore WS, Strain JJ. (2000) Marginal copper deficiency and atherosclerosis. Biol. Trace Elem. Res. 78:179-89.
51. Fujioka Y, Yokoyama M. (2005) Magnesium, cardiovascular risk factors and atherosclerosis. Clin. Calcium 15:221-5.
52. Qayyum R, Schulman P. (2005) Iron and atherosclerosis. Clin. Cardiol. 28:119-22.
53. Amighi J et al. (2004) Low serum magnesium predicts neurological events in patients with advanced atherosclerosis. Stroke 35:22-7.
54. Ravaglia G et al. (2000) Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥ 90 y. Am. J. Clin. Nutr. 711:590-8.