Development of hepatocellular carcinoma in a patient with Crohn's disease treated with azathioprine

Digestive Diseases and Sciences

Volumn 52, Issue 10, 2007, Pages 2748-2750

  Samarasena, Jason ^a,b   Borgaonkar, Mark ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b NONE   (United States)

Author keywords

Azathioprine; Crohn's disease; Hepatocellular carcinoma; Inflammatory bowel disease

Indexed keywords

AZATHIOPRINE; DICLOFENAC; MESALAZINE; METRONIDAZOLE; PREDNISONE;

ANAMNESIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CROHN DISEASE; HISTOPATHOLOGY; HUMAN; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER FUNCTION TEST; MALE; PRIORITY JOURNAL;

ADULT; AZATHIOPRINE; BIOPSY; CARCINOMA, HEPATOCELLULAR; CROHN DISEASE; DIAGNOSIS, DIFFERENTIAL; FATAL OUTCOME; HUMANS; LIVER NEOPLASMS; MALE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 34548494130     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9613-3     Document Type: Article

References (22)

1. Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB (2004) Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology 127:1372-1378
2. Chen CJ, Wang LY, Lu SN, Wu MH, You SL, Zhang YJ, Wang LW, Santella RM (1996) Elevated aflatoxin exposure and increased risk of hepatocellular carcinoma. Hepatology 24(1):38-42
3. Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe MF, Park HD, Chen GC, Chen G, Yu SZ (1996) Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 17(6):1317-1321
4. Bralet MP, Regimbeau JM, Pineau P, Dubois S, Loas G, Degos F, Valla D, Belghti J, Degott C, Terris B (2000) Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases. Hepatology 32:200-204
5. Kalayci C, Johnson PJ, Davies SE, Williams R (1991) Hepatitis B virus related hepatocellular carcinoma in the non-cirrhotic liver. J Hepatol 12(1):54-59
6. Trevisani F, D'Intino PE, Caraceni P, Pizzo M, Stafanini GF, Mazziotti A, Grazi GL, Gozzetti G, Gasbarrini G, Bernardi M (1995) Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients. Cancer 75(9):2220-2232
7. El-Refaie A, Savage K, Bhattacharya S, Khakoo S, Harrison TJ, el-Batanony M, Soliman el-S, Nasr S, Mokhtar N, Amer K, Scheuer PJ, Dhillon AP (1996) HCV-associated hepatocellular carcinoma without cirrhosis. J Hepatol 24(3):277-285
8. Bernstein CN, Blanchard JF, Kliewer, Wajda A (2001) Cancer risk is patients with inflammatory bowel disease, a population based study. Cancer 91:854-852
9. Bernstein D, Rogers A (1996) Malignancy in Crohn's disease. Am J Gastroenterol 91:434-440
10. Clevers H (2004) At the crossroads of inflammation and cancer. Cell 118:671-674
11. Oya H, Sato S, Yamamoto S, Tekeishi T, Kobayoshi T, Hatakeyama K (2004) Living related donor liver transplantation for primary sclerosing cholangitis with hepatocellular carcinoma and crohn's disease: a case report. Transplant Proc 36:2297-2298
12. Harnois DM, Gores GJ, Ludwig J, Steers JL, LaRusso NF, Wiesner RH (1997) Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular carcinoma? J Hepatol 27(3):512-516
13. Russman S, Zimmerman A, Krahenbuhl, Kern B, Reichen J (2001) Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis. Eur J Gastroenterol Hepatol 13:287-290
14. Nakao K, Tsunoda A, Shimizu Y, Takenaka K, Morohara K, Suzuki N, Yamazaki K, Aoki T, Hoshino M, Kusano M, Kitadai E, Kurihara T, Tekeuchi Y, Imawari M (2005) Development of hepatocellular carcinoma following treatment with 6-mercaptopurine for ulcerative colitis: investigation of chromosomal aberration by comparative genomic hybridization. Int J Clin Oncol 10:281-284
15. Borum ML (2001) Unusual development of hepatocellular carcinoma in a patient with crohn's disease. Dig Dis Sci 46:2199-2200
16. Cattan S, Wendum D, Chazouilleres O, Schmitz J, Gendre JP (2000) Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. Hum Pathol 31:874-876
17. Lee FL, Murray SM, Prior J, Shreeve DR (1983) Primary liver cell cancer occurring in association with Crohn's disease treated with prednisolone and azathioprine. Hepatogastroenterology 30:188-189
18. Romagnuolo J, Sadowski DC, Lalor E, Jewell L, Thomson ABR (1998) Cholestatic hepatocellular injury with azathioprine: a case report and review of mechanisms of hepatotoxicity. Can J Gastroenterol 12:479-483
19. Nzeako UC, Goodman ZD, Ishak KG (1996) Hepatocellular carcinoma and nodular regenerative hyperplasia: possible pathogenetic relationship. Am J Gastroenterol 91(5):879-884
20. Fraser AG, Orchard TR, Robinson EM, Jewell DP (2002) Long term risk of malignancy after treatment of inflammatory bowel disease with azathioprine. Aliment Pharmacol Ther 16:1225-1232
21. Connell WR, Kamm MA, Dickson M, Balkwill AM, Ritchie JK, Lennard-Jones JE (1994) Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet 343:1249-1252
22. Korelitz BI, Mirsky FJ, Fleisher MR, Warman JI, Wisch N, Gleim GW (1999) Malignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurine. Am J Gastroenterol 94(11):3248-3253