Neonatal vitamin K prophylaxis in Great Britain and Ireland: The impact of perceived risk and product licensing on effectiveness

Archives of Disease in Childhood

Volumn 92, Issue 9, 2007, Pages 754-758

  Busfield, Alison ^a   McNinch, Andrew ^a   Tripp, John ^b  

^a ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^b PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHYTOMENADIONE; VITAMIN K GROUP;

ARTICLE; ARTIFICIAL MILK; BREAST FEEDING; CLINICAL PRACTICE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; HUMAN; NEWBORN CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROPHYLAXIS; SINGLE DRUG DOSE; UNITED KINGDOM; VITAMIN K DEFICIENCY; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ANTIFIBRINOLYTIC AGENTS; DRUG APPROVAL; FEMALE; GREAT BRITAIN; HEMORRHAGIC DISEASE OF NEWBORN; HUMANS; INFANT, NEWBORN; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; IRELAND; PREGNANCY; VITAMIN K;

EID: 34548483216     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.2006.105304     Document Type: Article

References (26)

1. Cornelissen M, von Kries R, Loughnan P, et al. Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 1997;156(2):126-30.
2. Golding J, Greenwood R, Birmingham K, et al. Childhood cancer, intramuscular vitamin K and pethidine given during labour. BMJ 1992;305:314-16.
3. Roman E, Fear NT, Ansell P, et al. United Kingdom Childhood Cancer Study. Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study. Br J Cancer 2003;89(7):1228-31.
4. Passmore SJ, Draper G, Brownbill P, et al. Case-control studies of relation between childhood cancer and neonatal vitamin K administration. BMJ 1998;316:178-84.
5. Roman E, Fear NT, Ansell P, et al. Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies. Br J Cancer 2002;86(1):63-9.
6. Department of Health. Vitamin K for newborn babies, PL/CMO(98)3. London: HMSO, 1998.
7. Barton JS, Tripp JH, McNinch AW. Neonatal vitamin K prophylaxis in the British Isles: current practice and trends. BMJ 1995;310:632- 3.
8. Expert Committee. Vitamin K prophylaxis in infancy. London: British Paediatric Association, 1992.
9. Philip RK, Gul R, Dunworth M, et al. Ireland lacks consensus on neonatal vitamin K prophylaxis. BMJ 2001;323:1068
10. McNinch AW, Tripp JH. Haemorrhagic disease of the newborn in the British Isles: two year prospective study. BMJ 1991;303:1105-9.
11. McNinch A, Busfield A, Tripp J. Vitamin K deficiency bleeding in infants in Great Britain and Ireland: British Paediatric Unit Surveys, 1993-4 and 2001-2. Arch Dis Child 2007;92:759-66.
12. McNinch AW, Orme RL, Tripp JH. Haemorrhagic disease of the newborn returns. Lancet 1983;1(8333):1089-90.
13. McNinch AW, Upton C, Samuels M, et al. Plasma concentrations after oral or intramuscular vitamin K1 in neonates. Arch Dis Child 1985;60(9):814-18.
14. Hansen KN, Minousis M, Ebbesen F. Weekly oral vitamin K prophylaxis in Denmark. Acta Paediatr 2003;92(7):802-5.
15. Loughnan PM, McDougall PN, Balvin H, et al. Late onset haemorrhagic disease in premature infants who received intravenous vitamin K1. J Paediatr Child Health 1996;32(3):268-9.
16. Greer FP, Marshall SP. Severson RR, et al. A new mixed micellar preparation for oral vitamin K prophylaxis: randomised controlled comparison with an intramuscular formulation in breast fed infants. Arch Dis Child 1998;79:300-5.
17. Bangh SA, Hughes KA, Roberts DJ, et al. Neonatal ergot poisoning: a persistent iatrogenic illness. Am J Perinatol 2005;22(5):239-43.
18. Bhandari V, Tin NO, Ahmed SR. Aspiration pneumonia in association with oral vitamin K [letter]. Arch Dis Child Fetal Neonatal Ed 2002;87(3):F232.
19. Ford GJ. Possible skin allergy reaction to oral vitamin K [letter]. J Paediatr Child Health 1993;29(3):241.
20. Croucher C, Azzopardi D. Compliance with recommendations for giving vitamin K to newborn infants. BMJ 1994;308:894-5.
21. Ansell P, Roman E, Fear NT, et al. Vitamin K policies and midwifery practice: questionnaire survey. BMJ 2001;322:1148-52.
22. American Academy of Pediatrics Committee on Fetus and Newborn Controversies concerning vitamin K and the newborn. Pediatrics 2003;112:191-2.
23. National Health and Medical Research Council. Joint statement and recommendations on vitamin K administration to newborn infants to prevent vitamin K deficiency bleeding. Available at http://www.nets.org.au/PDF/ Vitamin_K_2001.PDF (accessed 11 June 2007).
24. Tripp JH, McNinch AW. The vitamin K debacle: cut the Gordian knot but first do no harm. Arch Dis Child 1998;79(4):295-7.
25. von Kries R. Oral versus intramuscular phytomenadione: safety and efficacy compared. Drug Saf 1999;21:1-6.
26. Hey E. Prevention of vitamin K deficiency in newborns. Br J Haematol 1999;106:255-6.