Evidence that non-lipid cardiovascular risk factors are associated with high prevalence of coronary artery disease in patients with heterozygous familial hypercholesterolemia or familial combined hyperlipidemia

International Journal of Cardiology

Volumn 121, Issue 2, 2007, Pages 178-183

  Skoumas, Ioannis ^a   Masoura, Constantina ^a   Pitsavos, Christos ^a   Tousoulis, Dimitris ^a   Papadimitriou, Lambros ^a   Aznaouridis, Konstantinos ^a   Chrysohoou, Christina ^a   Giotsas, Nikolaos ^a   Toutouza, Marina ^a   Tentolouris, Costas ^a   Antoniades, Charalambos ^a   Stefanadis, Christodoulos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Cardiovascular risk factors; Coronary artery disease; Familial combined hyperlipidemia; Heterozygous familial hypercholesterolemia; Lipids

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DIABETES MELLITUS; FAMILIAL HYPERCHOLESTEROLEMIA; FAMILIAL HYPERLIPEMIA; FEMALE; HETEROZYGOTE; HUMAN; HYPERTENSION; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR;

ADULT; CORONARY ARTERIOSCLEROSIS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA, FAMILIAL COMBINED; LIPIDS; MALE; MIDDLE AGED; PREVALENCE; RISK FACTORS;

EID: 34548482526     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2006.11.005     Document Type: Article

References (24)

1. Chaves F.J., Real J.T., Garsia-Garsia A.B., et al. Genetic diagnosis of familial hypercholesterolemia in a South European outbreed population: influence of low-density lipoprotein (LDL) receptor gene mutations on treatment response to simvastatin in total, LDL, and high-density lipoprotein cholesterol. J Clin Endocrinol Metab 86 (2001) 4926-4932
2. Voors-Pette C., and de Bruin T.W. Excess coronary heart disease in Familial Combined Hyperlipidemia, in relation to genetic factors and central obesity. Atherosclerosis 157 (2001) 481-489 Erratum in: Atherosclerosis 2001;159:245
3. Scientific Steering Committee on behalf of the Simon Broome Register Group. Risk of fatal coronary heart disease in familial hypercholesterolemia. Br Med J 303 (1991) 893-896
4. Dedoussis G., Skoumas J., Pitsavos C., et al. FH clinical phenotype in Greek patients with LDL-R defective vs. negative mutations. Eur J Clin Investig 34 (2004) 402-409
5. Veerkamp M.J., de Graaf J., Bredie S.J., Hendriks J.C., Demacker P.N., and Stalenhoef A.F. Diagnosis of familial combined hyperlipidemia based on lipid phenotype expression in 32 families: results of a 5-year follow-up study. Arterioscler Thromb Vasc Biol 22 (2002) 274-282
6. Panagiotakos D.B., Pitsavos C., Skoumas J., et al. Importance of LDL/HDL cholesterol ratio as a predictor for coronary heart disease events in patients with heterozygous familial hypercholesterolaemia: a 15-year follow-up (1987-2002). Curr Med Res Opin 19 (2003) 89-94
7. Jansen A.C., van Aalst-Cohen E.S., Tanck M.W., et al. The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients. J Intern Med 256 (2004) 482-490
8. Veerkamp M.J., de Graaf J., Hendriks J.C., Demacker P.N., and Stalenhoef A.F. Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study. Circulation 22 109 (2004) 2980-2985
9. Expert Panel on Detection. Evaluation and treatment of high blood cholesterol in adults (2001) executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285 (2001) 2486-2497
10. Eckel R.H. Familial combined hyperlipidemia and insulin resistance: distant relatives linked by intra-abdominal fat?. Arterioscler Thromb Vasc Biol 21 (2001) 469-470
11. Civeira F. International Panel on Management of Familial Hypercholesterolemia. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis 173 (2004) 55-68
12. Pitsavos C., Panagiotakos D.B., Chrysohoou C., and Stefanadis C. Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study. BMC Public Health 3 (2003) 32
13. Rader D.J., Cohen J., and Hobbs H.H. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest 111 (2003) 1795-1803
14. Carr M.C., and Brunzell J.D. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab 89 (2004) 2601-26017
15. Shoulders C.C., Johnes E.L., and Naoumona R.P. Genetics of familial combined hyperlipidemia and risk of coronary heart disease. Hum Mol Genet 13 (2004) 149-160
16. Williams R.R., Hunt S.C., Hopkins P.N., et al. Familial dyslipidemic hypertension. Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. JAMA 259 (1988) 333-344
17. Hunt S.C., Wu L.L., Hopkins P.N., et al. Apolipoprotein, LDL subfraction and insulin association with familial combined hyperlipidemia. Atherosclerosis 9 (1989) 335-343
18. Panagiotakos D.B., Pitsavos C., Chrysohoou C., Stefanadis C., and Toutouzas P. Risk stratification of coronary heart disease in Greece: final results from the CARDIO2000 Epidemiological Study. Prev Med 35 (2002) 548-556
19. Pitsavos C., Chrysohoou C., Panagiotakos D.B., et al. Association of leisure-time physical activity on inflammation markers (C-reactive protein, white cell blood count, serum amyloid A, and fibrinogen) in healthy subjects (from the ATTICA study). Am J Cardiol 91 (2003) 368-370
20. Neil H.A., Seagroatt V., Betteridge D.J., et al. Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Heart 90 (2004) 1431-1437
21. Ferrieres J., Lambert J., Lussier-Cacan S., and Davignon J. Coronary artery disease in heterozygous familial hypercholesterolemia patients with the same LDL receptor gene mutation. Circulation 92 (1995) 290-295
22. Hill J.S., Hayden M.R., Frohlich J., and Pritchard P.H. Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia. Arterioscler Thromb 11 (1991) 290-297
23. Beaumont V., Jacotot B., and Beaumont J.L. Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis. A comparative study of genetic and environmental factors in 274 heterozygous cases. Atherosclerosis 24 (1976) 441-450
24. de Sauvage Nolting P.R., Defesche J.C., Buirma R.J., Hutten B.A., Lansberg P.J., and Kastelein J.J. Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia. J Intern Med 253 (2003) 1618