Investigation of the origin of ephedrine and methamphetamine by stable isotope ratio mass spectrometry: A Japanese experience

Bulletin on Narcotics

Volumn 57, Issue 1-2, 2007, Pages 63-78

  Makino, Y ^a   Urano, Y ^b   Nagano, T ^b  

^a Ministry of Health Labour and Welfare   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Drug profiling; Ephedrine; IRMS; Methamphetamine; Origin; Precursor

Indexed keywords

EPHEDRINE; METHAMPHETAMINE; STREET DRUG;

ARTICLE; CHEMISTRY; COMMERCIAL PHENOMENA; DRUG ABUSE; DRUG CONTAMINATION; DRUG CONTROL; DRUG FORMULATION; HUMAN; ISOTOPE LABELING; JAPAN; LEGAL ASPECT; MASS SPECTROMETRY; METHODOLOGY; SYNTHESIS;

AMPHETAMINE-RELATED DISORDERS; COMMERCE; DRUG AND NARCOTIC CONTROL; DRUG COMPOUNDING; DRUG CONTAMINATION; EPHEDRINE; HUMANS; ISOTOPE LABELING; JAPAN; MASS SPECTROMETRY; METHAMPHETAMINE; STREET DRUGS;

EID: 34548478124     PISSN: 0007523X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Ken Tanaka, Takeshi Ohmori and Takako Inoue, "Analysis of impurities in illicit methamphetamine", Forensic Science International, vol. 56, 1992, pp. 157-165.
2. Yoshiteru Marumo, Takako Inoue and Shigeki Seta, "Analysis of inorganic impurities in seized methamphetamine samples", Forensic Science International, vol. 69, 1994, pp. 89-95.
3. Yukiko Makino, Yasuteru Urano and Tetsuo Nagano, "Impurity profiling of ephedrines in methamphetamine by high-performance liquid chromatography", Journal of Chromatography A, vol. 947, 2002, pp. 151-154.
4. Naoki Kurashima and others, "Determination of origin of ephedrine used as precursor for illicit methamphetamine by carbon and nitrogen stable isotope ratio analysis", Analytical Chemistry, vol. 76, No. 14 (2004), pp. 4233-4236.
5. B. Remberg and A. H. Stead, "Drug characterization/impurity profiling, with special focus on methamphetamine: recent work of the United Nations International Drug Control Programme", Bulletin on Narcotics, vol. LI, Nos. 1 and 2 (1999).
6. M. Lambrechts and K. E. Rasmussen, "Leuckart-specific impurities in amphetamine and methamphetamine seized in Norway", Bulletin on Narcotics, vol. XXXVI, No. 1, 1984, pp. 47-57.
7. T. S. Cantrell and others, "A study of impurities found in methamphetamine synthesized from ephedrine", Forensic Science International, vol. 39, 1988, pp. 39-54.
8. H. F. Skinner, "Methamphetamine synthesis via hydriodic acid/red phosphorus reduction of ephedrine", Forensic Science International, vol. 48, 1990, pp. 123-134.
9. K. L. Windahl and others, "Investigation of the impurities found in methamphetamine synthesised from pseudoephedrine by reduction with hydriodic acid and red phosphorus", Forensic Science International, vol. 76, 1995, pp. 97-114.
10. Tetsuo Nagano and others, "The basic research on methamphetamine profiling", report funded by a health sciences research grant from the Ministry of Health, Labour and Welfare of Japan, 1999, pp. 60-62.
11. Tetsuo Nagano and others, "The basic research on methamphetamine profiling", report funded by a health sciences research grant from the Ministry of Health, Labour and Welfare of Japan, 2000, pp. 53-57.
12. Tetsuo Nagano and others, "The basic research on methamphetamine profiling", report funded by a health sciences research grant from the Ministry of Health, Labour and Welfare of Japan, 2001, pp. 61-64.
13. A. H. Beckett, G. R. Jones and D. A. Hollingsbee, "Degradation of (-)-ephedrine in solution and during extraction with diethyl ether", Journal of Pharmacy and Pharmacology, vol. 30, 1978, pp. 15-19.
14. M. H. O'Leary, "Carbon isotope fractionation in plants", Phytochemistry, vol. 20, 1981, pp. 553-567.
15. G. D. Farquhar, J. R. Ehleringer and K. T. Hubick, "Carbon isotope discrimination and photosynthesis", Annual Review Plant Physiology and Plant Molecular Biology, vol. 40, 1989, pp. 503-537.
16. International Narcotics Control Board, "Precursors and chemicals frequently used in the illicit manufacture of narcotic drugs and psychotropic substances" (United Nations publication, Sales No. E.05.XI.6) (2005), pp. 14-17.
17. United Nations Office for Drug Control and Crime Prevention (Scientific Section), Drug Characterization/Impurity Profiling: Background and Concepts (United Nations publication, Sales No. E.01.XI.10) (2001).
18. T. D. Meehan and others, "Using hydrogen isotope geochemistry to estimate the natal latitudes of immature Cooper's hawks migrating through the Florida Keys", Condor, vol. 103, 2001, pp. 11-20.