22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells

Neuroscience

Volumn 148, Issue 2, 2007, Pages 441-453

  Yao, Z X ^a   Han, Z ^a   Xu, J ^a   Greeson, J ^b   Lecanu, L ^a   Papadopoulos, V ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b Samaritan Pharmaceuticals   (United States)

Author keywords

Alzheimer's disease; glial cell line derived neurotrophic factor; neurogenesis; neurosteroids

Indexed keywords

CHOLESTEROL; CHOLESTEROL DERIVATIVE; CYTOSKELETON PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA 2; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 2B; NEUROFILAMENT PROTEIN; NEUROSTEROID; PROTEIN NF200; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASSAY; ASTROCYTE; BINDING AFFINITY; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CHOLESTEROL PROTEIN BINDING BLOT ASSAY; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG UPTAKE; ENANTIOMER; HUMAN; HUMAN CELL; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR BINDING; STEM CELL; STEREOSPECIFICITY; SYMPATHETIC NERVE; TERATOCARCINOMA;

BROMODEOXYURIDINE; CELL DEATH; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; HYDROXYCHOLESTEROLS; L-LACTATE DEHYDROGENASE; NERVE TISSUE PROTEINS; NEURONS; TERATOCARCINOMA; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TRITIUM;

EID: 34548456890     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.06.013     Document Type: Article

References (65)

1. Airaksinen M.S., and Saarma M. The GDNF family: Signalling, biological functions and therapeutic value. Nat Rev Neurosci 3 (2002) 383-394
2. Airaksinen M.S., Titievsky A., and Saarma M. GDNF family neurotrophic factor signaling: four masters, one servant?. Mol Cell Neurosci 13 (1999) 313-325
3. Akwa Y., Schumacher M., Jung-Testas I., and Baulieu E.E. Neurosteroids in rat sciatic nerves and Schwann cells. CR Acad Sci III (France) 316 (1993) 410-414
4. Andrews P.W. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 103 (1984) 285-293
5. Kip1 for embryonal carcinoma cell survival and differentiation. Oncogene 18 (1999) 6241-6251
6. Kip1. Oncogene 21 (2002) 1739-1749
7. Bani-Yaghoub M., Bechberger J.F., Underhill T.M., and Naus C.C. The effects of gap junction blockage on neuronal differentiation of human Ntera2/clone D1 cells. Exp Neurol 156 (1999) 16-32
8. Bani-Yaghoub M., Felker J.M., and Naus C.C. Human NT2/D1 cells differentiate into functional astrocytes. Neuroreport 10 (1999) 3843-3846
9. Baulieu E.E., and Robel P. Neurosteroids: a new brain function?. J Steroid Biochem Mol Biol 37 (1990) 395-403
10. Binder L.I., Frankfurter A., Kim H., Caceres A., Payne M.R., and Rebhun L.I. Heterogeneity of microtubule-associated protein 2 during rat brain development. Proc Natl Acad Sci U S A 81 (1984) 5613-5617
11. 1 receptors. Mol Neuropharmacol 3 (1993) 117-126
12. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
13. Chang J.Y., and Liu L.Z. Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells. Neurochem Int 32 (1998) 317-323
14. Childers S.R., Creese I., Snowman A.M., and Snyder S.H. Opiate receptor binding affected differentially by opiates and opioid peptides. Eur J Pharmacol 55 (1979) 11-18
15. Clark A.F., Lane D., Wilson K., Miggans S.T., and McCartney M.D. Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol. Invest Ophthalmol Vis Sci 37 (1996) 805-813
16. Clementi F., and Sher E. Antibody induced internalization of acetylcholine nicotinic receptor: kinetics, mechanism and selectivity. Eur J Cell Biol 37 (1985) 220-228
17. Dixon R., Furutachi T., and Lieberman S. The isolation of crystalline 22R-hydroxycholesterol and 20 alpha, 22R-dihydroxycholesterol from bovine adrenals. Biochem Biophys Res Commun 49 (1970) 161-165
18. Eckert R.L., and Katzenellenbogen B. Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Res 42 (1982) 139-144
19. Garner C.C., Brugg B., and Matus A. A 70 kDa microtubule-associated protein (MAP2c), related to MAP2. J Neurochem 50 (1988) 609-615
20. Ge R.S., Dong Q., Sottas C.M., Papadopoulos V., Zirkin B.R., and Hardy M.P. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Proc Natl Acad Sci U S A 103 (2006) 2719-2724
21. Guillemain I., Fontes G., Privat A., and Chaudieu I. Early programmed cell death in human NT2 cell cultures during differentiation induced by all-trans-retinoic acid. J Neurosci Res 71 (2003) 38-45
22. Hall P.F. Role of cytochromes P-450 in the biosynthesis of steroid hormones. Vitam Horm 42 (1985) 315-368
23. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., and Mangelsdorf D.J. An oxysterol signaling pathway mediated by the nuclear receptor LXRα. Nature 383 (1996) 728-731
24. Jung-Testas I., Hu Z., Baulieu E.E., and Robel P. Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125 (1989) 2083-2091
25. Kolsch H., Lutjohann D., Tulke A., Bjorkhem I., and Rao M.L. The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. Brain Res 818 1 (1999) 171-175
26. 3H](+)PN 200-110 binding to dihydropyridine receptors associated with calcium channels in rat cerebral cortex and heart. Life Sci 35 (1984) 721-732
27. Lee V.M., and Andrews P.W. Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins. J Neurosci 6 (1986) 514-521
28. Marvison J.C., Vazquez J., Garcia-Calvo M., Mayor Jr. F., Ruiz Gomez A., Valdivieso F., and Benavides J. The glycine receptor: pharmacological studies and mathematical modeling of the allosteric interaction between the glycine-and strychnine-binding sites. Mol Pharmacol 30 (1986) 590-597
29. Megiorni F., Mora B., Indovina P., and Mazzilli M.C. Expression of neuronal markers during NTera2/cloneD1 differentiation by cell aggregation method. Neurosci Lett 373 (2005) 105-109
30. 3H]kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res 252 (1982) 91-100
31. 3H]α-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and a filtration assay. Neurochem Res 12 (1987) 775-781
32. Nat R., Nilbratt M., Narkilahti S., Winblad B., Hovatta O., and Nordberg A. Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures. Glia 55 (2007) 385-399
33. Ong J.M., Aoki A.M., Seigel G.M., Sacerio I., Castellon R., Nesburn A.B., and Kenney M.C. Oxysterol-induced toxicity in R28 and ARPE-19 cells. Neurochem Res 28 6 (2003) 883-891
34. Ozdener H. Inducible functional expression of Bcl-2 in human astrocytes derived from NTera-2 cells. J Neurosci Methods 159 (2007) 8-18
35. 3H]Cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 39 (1991) 9-12
36. 3H]Ryanodine binding sites in rat brain demonstrated by membrane binding and autoradiography. Brain Res 542 (1992) 135-140
37. Papadopoulos V., Guarneri P., Krueger K.E., Guidotti A., and Costa E. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sci U S A 89 (1992) 5113-5117
38. Parker G.J., Law T.L., Lenoch F.J., and Bolger R.E. Development of high throughput screening assays using fluorescence polarization: nuclear receptor-ligand-binding and kinase/phosphatase assays. J Biomol Screen 5 (2000) 77-88
39. Paul M.P., and Purdy R.H. Neuroactive steroids. FASEB J 6 (1992) 2311-2322
40. 3H]spiroperidol. Mol Pharmacol 16 (1979) 687-699
41. Pleasure S.J., Page C., and Lee V.M.-Y. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 12 (1992) 1802-1815
42. Pleasure S.J., and Lee V.M.-Y. NTera 2 cell: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J Neurosci Res 35 (1993) 585-602
43. Rao M.V., and Nixon R.A. Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review. Neurochem Res 28 (2003) 1041-1047
44. 3H]desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines. J Pharmacol Exp Ther 237 (1986) 731-738
45. Roberts E. Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) as neural facilitators: effects on brain tissue in culture and on memory in young and old mice: A cyclic GMP hypothesis of action of DHEA and DHEAS in nervous system and other tissues. In: Kalimi M., and Regelson W. (Eds). The biologic role of dehydroepiandrosterone (DHEA) (1990), Walter de Gruyter, Berlin 13-42
46. Ross M.E. Cell division and the nervous system: regulating the cycle from neural differentiation to death. Trends Neurosci 19 (1996) 62-68
47. 3 receptor in insect cells using the baculovirus expression system. Proc Natl Acad Sci U S A 88 (1991) 6555-6559
48. Sanchez M.P., Silos-Santiago I., Frisen J., He B., Lira S.A., and Barbacid M. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382 (1996) 70-73
49. Sandhu J.K., Sikorska M., and Walker P.R. Characterization of astrocyte derived from human NTera-2/D1 embryonal carcinoma cells. J Neurosci Res 68 (2002) 604-614
50. 3H]Diltiazem binding to calcium channel antagonist recognition sites in rat cerebral cortex. Eur J Pharmacol 111 (1985) 273-277
51. Sharples C.G.V., Kaiser S., Soliakov L., Marks M.J., Collins A.C., Washburn M., Wright E., Spencer J.A., Gallagher T., Whiteaker P., and Wonnacott S. UB-165: A novel nicotinic agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci 20 (2000) 2783-2791
52. 3H]MDL 105,519, a high affinity radioligand for the NMDA receptor-associated glycine recognition site. J Pharmacol Exp Ther 279 (1995) 62-68
53. 3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain. Eur J Pharmacol 192 (1991) 19-24
54. Tsuji A., Sato H., Kume Y., Tamai I., Okesaki E., Nagat O., and Kato H. Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes. Antimicrob Agents Chemother 32 (1988) 190-194
55. Vallee M., Mayo W., Darnaudery M., Corpechot C., Young J., Koehl M., Moal M.L., Baulieu E.E., Robel P., and Simon H. Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus. Proc Natl Acad Sci U S A 94 (1997) 14865-14870
56. 3H]TCP) binds to two different sites in rat brain. Localization by autoradiographic and biochemical techniques. Brain Res 378 (1986) 133-141
57. Vindelov L.L., Christensen I.J., and Nissen N.I. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3 (1983) 323-327
58. Wagner J.A., Snowman A.M., Biswas A., Olivera B.M., and Snyder S.H. ω-Conotoxin GVIA binding to high-affinity receptor in brain: characterization, calcium sensitivity, and solubilization. J Neurosci 8 (1988) 3354-3359
59. Webb M., Graham C., and Walsh F. Neuronal differentiation of cloned human teratoma cells in response to retinoic acid in vitro. J Neuroimmunol 11 (1986) 67-86
60. Widenfalk J., Nosrat C., Tomac A., Westphal H., Hoffer B., and Olson L. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. J Neurosci 17 (1997) 8506-8519
61. Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., and Mangelsdorf D.J. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9 (1995) 1033-1045
62. Yao Z.-X., Brown R.C., Teper G., Greeson J., and Papadopoulos V. 22R-Hydroxycholesterol protects neuronal cells from β-amyloid-induced cytotoxicity by binding to β-amyloid peptide. J Neurochem 83 (2002) 1110-1119
63. Yao Z., Drieu K., and Papadopoulos V. The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. Brain Res 889 (2001) 181-190
64. Yao Z.-X., and Papadopoulos V. Function of β-amyloid in cholesterol transport: a lead to neurotoxicity. FASEB J 16 (2002) 1677-1679
65. 3H]methyltrienolone (R1881) in the presence of progesterone receptor. Endocrinology 104 (1979) 1007-1012