6-Methylprednisolone down-regulates IRAK-M in human and murine osteoclasts and boosts bone-resorbing activity: A putative mechanism for corticoid-induced osteoporosis

Journal of Leukocyte Biology

Volumn 82, Issue 3, 2007, Pages 700-709

  Soares Schanoski, Alessandra ^a   Gómez Piña, Vanesa ^a   Del Fresno, Carlos ^a   Rodríguez Rojas, Alexandro ^a   García, Felipe ^b   Glaría, Alberto ^c   Sánchez, Miriam ^a   Vallejo Cremades, María Teresa ^a   Baos, Rosa ^a   Fuentes Prior, Pablo ^d   Arnalich, Francisco ^a   López Collazo, Eduardo ^a,e  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Discovery Unit   (Spain)

^c Instituto Madrileno de Oncologia   (Spain)

^d Institut Català de Ciències Cardiovasculars   (Spain)

^e HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Glucocorticoids; IL 1R; TLR

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 1R ASSOCIATED KINASE M; METHYLPREDNISOLONE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG INHIBITION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ADRENAL CORTEX HORMONES; ANIMALS; BLOTTING, WESTERN; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; GLUCOCORTICOIDS; HUMANS; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; METHYLPREDNISOLONE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MONOCYTES; OSTEOCLASTS; OSTEOPOROSIS; RNA, MESSENGER; TARTRATES;

MURINAE; MUS;

EID: 34548449892     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1106673     Document Type: Article

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