Bisphosphonate therapy for reduced bone mineral density during treatment of acute lymphoblastic leukemia in childhood and adolescence: A report of preliminary experience

Journal of Pediatric Hematology/Oncology

Volumn 29, Issue 9, 2007, Pages 613-616

  Lethaby, Christopher ^a   Wiernikowski, John ^b   Sala, Alessandra ^c,e   Naronha, Marissa ^c   Webber, Colin ^c,d   Barr, Ronald D ^a,c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b MCMASTER CHILDREN S HOSPITAL   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d HAMILTON HEALTH SCIENCES   (Canada)

^e UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Acute; Child adolescent; Diphosphonates; Leukemia; Lymphocytic; Osteoporosis

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; TUMS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BONE DENSITY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; LUMBAR SPINE; MALE; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VELOCITY;

EID: 34548443354     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e318142b7a1     Document Type: Article

References (21)

1. Ries LAG, Eisner MP, Kosary CL, et al, eds. SEER Cancer Statistics Review, 1975-1999. Bethesda MD: National Cancer Institute; 2002.
2. Hewitt M, Weiner SL, Simone JV, eds, for the National Cancer Policy Board. Childhood Cancer Survivorship. Improving Care and Quality of Life. Washington, DC: The National Academies Press; 2003.
3. Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572-1582.
4. Pfeilschifter J, Diel IJ. Osteoporosis due to cancer treatment: pathogenesis and management. J Clin Oncol. 2000;18:1570-1593.
5. Sala A, Barr RD. Osteopenia and cancer in children and adolescents - the fragility of success. Cancer. 2007;109:1420-1421.
6. Sala A, Mattano L, Barr RD. Osteonecrosis in children and adolescents with cancer - an adverse effect of systemic therapy. Eur J Cancer. 2007;43:683-689.
7. The Writing Group for the ISCD Position Development Conference. Diagnosis of osteoporosis in men, pre-menopausal women and children. J Clin Densitom. 2004;7:17-26.
8. Saggese G, Baroncelli GI, Bertelloni S. Osteoporosis in children and adolescents: diagnosis, risk factors and prevention. J Pediatr Endocrinol Metab. 2001;14:833-859.
9. Wiernikowski JT, Barr RD, Webber C, et al. Alendronate for steroid-induced osteopenia in children with acute lymphoblastic leukemia or non-Hodgkin lymphoma. J Oncol Pharmacy Pract. 2005;11:51-56.
10. Silverman LB, Declerck L, Gelber RD, et al. Results of Dana Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia. Leukemia. 2004;14:2247-2256.
11. Halton JM, Atkinson SA, Fraher L, et al. Altered mineral metabolism and bone mass in children during treatment for acute lymphoblastic leukemia. J Bone Miner Res. 1996;11:1774-1783.
12. Webber CE, Beaumont LF, Morrison J, et al. Age-predicted values for lumbar spine, proximal femur and whole body bone mineral density: results from a population of normal children aged 3-18 years. Can Assoc Radiol J. 2007;58:37-45.
13. Sala A, Talsma D, Webber C, et al. Bone mineral status after treatment of malignant lymphoma in childhood and adolescence. Eur J Cancer Care. 2007;16:373-379.
14. Barr RD, Guo CY, Wiernikowski J, et al. Osteopenia in children with acute lymphoblastic leukemia. A pilot study of amelioration with pamidronate. Med Pediatr Oncol. 2002;39:44-46.
15. Baroncelli CI, Bertelloni S, Sodini F, et al. Osteoporosis in children and adolescents. Etiology and management. Pediatr Drugs. 2005;7:295-323.
16. Margolin JF, Steuber CP, Poplack DG. Acute lymphoblastic leukemia. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2006:538-590.
17. Leonard MB, Propert KJ, Zemel BS, et al. Discrepancies in pediatric bone mineral density reference data: potential for mis-diagnosis of osteopenia. J Pediatr. 1999;135:182-188.
18. van der Sluis IM, van den Heuvel-Eibrink MM, Hahlen K, et al. Altered bone mineral density and body composition and increased fracture risk in childhood acute lymphoblastic leukemia. J Pediatr. 2002;141:204-210.
19. Agarwala S, Jain D, Joshi VR, et al. Efficacy of Alendronate, a bisphosphonate, in the treatment of avn of the hip. Rheumatology. 2005;44:352-359.
20. Nishii T, Sugano N, Miki H, et al. Does alendronate prevent collapse in osteonecrosis of the femoral head. Clin Orthop Relat Res. 2006;443:273-279.
21. Lai KA, Shen WJ, Yang CY, et al. The use of alendronate to prevent early collapse of the femoral head in patients with non-traumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg. 2005;87A:2155-2159.