Antepartum treatment without early cordocentesis for standard-risk alloimmune thrombocytopenia: A randomized controlled trial

Obstetrics and Gynecology

Volumn 110, Issue 2 I, 2007, Pages 249-255

  Berkowitz, Richard L ^a   Lesser, Martin L ^b   McFarland, Janice G ^b   Wissert, Megan ^b   Primiani, Andrea ^b   Hung, Crystal ^b   Bussel, James B ^b  

^a New York Presbyterian Hospital Columbia University Medical Center   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; PREDNISONE; ANTIINFLAMMATORY AGENT; THROMBOCYTE ANTIGEN;

ADULT; ARTHRALGIA; ARTICLE; BLOOD SAMPLING; BRAIN HEMORRHAGE; CESAREAN SECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORDOCENTESIS; DRUG DOSE INCREASE; DRUG ERUPTION; DRUG INDUCED HEADACHE; EDEMA; FATIGUE; FEMALE; FETUS BLOOD; GESTATIONAL AGE; HUMAN; INCIDENCE; INSOMNIA; MAJOR CLINICAL STUDY; MOOD DISORDER; MULTICENTER STUDY; NERVOUSNESS; PREGNANCY DIABETES MELLITUS; PRENATAL CARE; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SALVAGE THERAPY; SIDE EFFECT; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT OUTCOME; CYTOLOGY; DRUG COMBINATION; DRUG EFFECT; IMMUNOLOGY; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PROSPECTIVE STUDY;

ADULT; ANTI-INFLAMMATORY AGENTS; ANTIGENS, HUMAN PLATELET; CORDOCENTESIS; DRUG COMBINATIONS; FEMALE; FETAL BLOOD; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INTRACRANIAL HEMORRHAGES; PLATELET COUNT; PREDNISONE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY OUTCOME; PROSPECTIVE STUDIES; THROMBOCYTOPENIA;

EID: 34548439081     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000270302.80336.dd     Document Type: Article

References (15)

1. Hohlfeld P, Forestier F, Kaplan C, Tissot JD, Daffos F. Fetal thrombocytopenia: a retrospective study of 5,194 fetal blood samplings. Blood 1994;84:1851-6.
2. Bussel JB, Zacharoulis S, Kramer K, McFarland JG, Pauliny J, Kaplan C. Clinical and diagnostic comparison of neonatal alloimmune thrombocytopenia to non-immune cases of thrombocytopenia. Pediatr Blood Cancer 2005;45:176-83.
3. Mao C, Guo J, Chituwo BM. Intraventricular haemorrhage and its prognosis, prevention and treatment in term infants. J Trop Pediatr 1999;45:237-40.
4. van Loghem JJ, Dorfmeijer H, van Hart M, Schreuder F. Serological and genetical studies on a platelet antigen (Zw). Vox Sang 1959;4:161-9.
5. Pearson HA, Shulman NR, Marder VJ, Cone TE Jr. Isoimmune neonatal thrombocytopenic purpura: clinical and therapeutic considerations. Blood 1964;23:154-77.
6. Herman JH, Jumbelic MI, Ancona RJ, Kickler TS. In utero cerebral hemorrhage in alloimmune thrombocytopenia. Am J Pediatr Hematol Oncol 1986;8:312-7.
7. Bussel JB, Berkowitz RL, McFarland JG, Lynch L, Chitbara N. Antenatal treatment of neonatal alloimmune thrombocytopenia. N Engl J Med 1988;319:1374-8.
8. Murphy MF, Metcalfe P, Waters AH, Ord J,Hambley H, Nicolaides K. Antenatal management of severe feto-maternal alloimmune thrombocytopenia: HLA incompatibility may affect responses to fetal platelet transfusions. Blood 1993;81:2174-9.
9. Lynch L, Bussel JB, McFarland JG, Chitkara U, Berkowitz RL. Antenatal treatment of alloimmune thrombocytopenia. Obstet Gynecol 1992;80:67-71.
10. Berkowitz RL, Kolb EA, McFarland JG, Wissert M, Primani A, Lesser M, et al. Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol 2006;107:91-6.
11. Birchall JE, Murphy MF, Kaplan C, Kroll H; European Fetomaternal Alloimmune Thrombocytopenia Study Group. European collaborative study of the antenatal management of feto-maternal alloimmune thrombocytopenia. Br J Haematol 2003;122:275-88.
12. Bussel JB, Berkowitz RL, Lynch L, Lesser ML, Paidas MJ, Huang CL, et al. Antenatal management of alloimmune thrombocytopenia with intravenous gamma-globulin: a randomized trial of the addition of low-dose steroids to intravenous gamma-globulin. Am J Obstet Gynecol 1996;174:1414-23.
13. Overton TG, Duncan KR, Jolly M, Letsky E, Fisk NM. Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: platelet dynamics and perinatal outcome. Am J Obstet Gynecol 2002;186:826-31.
14. Paidas MJ, Berkowitz RL, Lynch L, Lockwood CJ, Lapinski R, McFarland JG, et al. Alloiummune thrombocytopenia: Fetal and neonatal losses related to cordocentesis. Am J Obstet Gynecol 1995;172:475-9.
15. Gaddipati S, Berkowitz RL, Lembet AA, Lapinski R, McFarland JG, Bussel JB, et al. Initial fetal platelet counts predict the response to intravenous gammaglobulin therapy in fetuses that are affected by PLA1 incompatibility. Am J Obstet Gynecol 2001;185:976-80.