Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl

Journal of Controlled Release

Volumn 122, Issue 2, 2007, Pages 135-140

  Diaz del Consuelo, Isabel ^a,b,c   Falson, Françoise ^b,c   Guy, Richard H ^d   Jacques, Yves ^e  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITÉ LYON 1   (France)

^c Centre Interuniversitaire de Recherche et d'Enseignement   (France)

^d University of Bath   (United Kingdom)

^e OM Pharma ^*  (Switzerland)

Author keywords

Bioadhesion; Buccal drug delivery; Esophagus; Fentanyl; Permeability barrier

Indexed keywords

ADHESIVES; DRUG DELIVERY; IONIZATION; MOLECULAR WEIGHT; PH EFFECTS; THICKNESS MEASUREMENT;

BIOADHESION; BUCCAL DRUG DELIVERY; BUCCAL SYSTEM; PERMEABILITY BARRIER;

BIOFILMS;

ADHESIVE AGENT; EUDRAGIT; FENTANYL; POVIDONE;

ANIMAL TISSUE; ARTICLE; BIOFILM; CHEEK MUCOSA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; EX VIVO STUDY; HEATING; HYDROPHILICITY; IN VITRO STUDY; IONIZATION; MOLECULAR WEIGHT; NONHUMAN; PERMEABILITY BARRIER; PH MEASUREMENT; PRIORITY JOURNAL; TRANSDERMAL PATCH;

ADHESIVENESS; ADMINISTRATION, BUCCAL; ANALGESICS, OPIOID; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DIFFUSION CHAMBERS, CULTURE; DRUG CARRIERS; DRUG COMPOUNDING; ESOPHAGUS; FENTANYL; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR WEIGHT; MUCOUS MEMBRANE; PERMEABILITY; POVIDONE; SOLUBILITY; SWINE;

EID: 34548438447     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.05.017     Document Type: Article

References (18)

1. Peng P.W.H., and Sandler A.N. A review of the use of fentanyl analgesia in the management of acute pain in adults. Anesthesiology 90 (1999) 576-599
2. Labroo R.B., Paine M.F., Thummel K.E., and Kharasch E.D. Fentanyl metabolism by human hepatic and intestinal cytrochrome P450 3A4: implication for interindividual variabiliry in disposition efficacy and drug interactions. Drug Metab. Dispos 25 (1997) 1072-1080
3. Gourlay G.K. Treatment of cancer pain with transdermal fentanyl. Lancet Oncol. 2 (2001) 165-172
4. Coluzzi P.H., Schwartzberg L., Conroy J.D., Charapata S., Gay M., Busch M.A., Chavez J., Ashley J., Lebo D., McCracken M., and Portenoy R.K. Breakthrough cancer pain: a randomized trial comparing oral transmucosal fentanyl citrate (OTFC) and morphine sulfate immediate release (MSIR). Pain 91 (2001) 123-130
5. Wertz P.W., and Squier C.A. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev Ther Drug Carr. Syst 8 (1991) 237-269
6. Streisand J.B., Varvel J.R., Stanski D.R., Le Maire L., Tarver S.D., and Stanley T.H. Absorption and bioavailability of oral transmucosal fentanyl citrate. Anesthesiology 75 (1991) 223-229
7. Anders R., and Merkle H.P. Evaluation of laminated muco-adhesive patches for buccal drug delivery. Int. J. Pharm. 49 (1989) 231-240
8. Diaz del Consuelo I., Pizzolato G.-P., Falson F., Guy R.H., and Jacques Y. Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue. J. Pharm. Sci. 94 (2005) 2777-2788
9. Diaz del Consuelo I., Jacques Y., Pizzolato G.-P., Guy R.H., and Falson F. Comparison of the lipid composition of porcine buccal and esophageal permeability barriers. Arch. Oral Biol. 50 (2005) 981-987
10. Orlando R.C., Lacy E.R., and Tobey N.A. Barriers to paracellular permeability in rabbit esophageal epithelium. Gastroenterology 102 (1992) 910-923
11. Hill M.W., Squier C.A., and Linder J.E. A histological method for the visualization of the intercellular permeability barrier in mammalian stratified squamous epithelia. Histochem J 14 (1982) 641-648
12. Jacques Y., and Guy R.H. Mucoadhesive polymers: a dual-purpose water pump involved in the mucosadhesion and transport of hydrophilic drugs? European Conference on Drug Delivery and Pharmaceutical Technology, Sevilla, Spain vol. 48 (10-12 May, 2004)
13. Roy S.D., and Flynn G.L. Solubility behavior of narcotic analgesics in aqueous media: solubilities and dissociation donstants of morphine fentanyl and sufentanil. Pharm. Res. 6 (1989) 147-151
14. Mortazavi S.A., and Smart J.D. An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J. Control. Release. 25 (1993) 197-203
15. Daniel J.C. The fibroblast and its products. In: Meyer J., Squier C.A., and Gerson S.J. (Eds). The structure and function of oral mucosa (1984), Pergamon Press, New York 159-177
16. M.J. Stablein, J. Meyer, The vascular system and blood supply, in: Meyer J., Squier C.A., Gerson S.J., (Eds.), The structure and function of oral mucosa, Pergamon Press, New York, 237-256.
17. Mak V.H.W., Potts R.O., and Guy R.H. Does hydratation affect intercellular lipid organization in the stratum corneum?. Pharm. Res. 8 (1991) 1064-1065
18. Thassu D., and Vyas S.P. Controlled transdermal occlusive delivery device of primaquine. Drug Dev. Ind. Pharm. 19 (1993) 1343-1356