Up-regulation of connexin 43 and gap junctional intercellular communication by Coleusin Factor is associated with growth inhibition in rat osteosarcoma UMR106 cells

Cell Biology International

Volumn 31, Issue 11, 2007, Pages 1420-1427

  Geng, Shuo ^a,b   Sun, Bo ^a,b   Liu, Shu ^a,b   Wang, Jingze ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Cell growth; Coleusin Factor; Connexin 43; Gap junctional intercellular communication; Osteosarcoma; Retinoic acid

Indexed keywords

COLEUSIN FACTOR; CONNEXIN 43; DITERPENOID; DYE; FSK 88; MESSENGER RNA; RETINOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL ASSAY; CELL COMMUNICATION; CELL MEMBRANE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; GAP JUNCTION; GENE EXPRESSION REGULATION; GROWTH INHIBITION; NONHUMAN; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; UPREGULATION;

ANIMALS; BONE NEOPLASMS; CELL COMMUNICATION; CELL LINE, TUMOR; CELL PROLIFERATION; CONNEXIN 43; FORSKOLIN; GAP JUNCTIONS; OSTEOSARCOMA; RATS; UP-REGULATION;

RATTUS;

EID: 34548422219     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2007.06.008     Document Type: Article

References (52)

1. Abu J., Batuwangala M., Herbert K., and Symonds P. Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6 (2005) 712-720
2. Conklin C.M., Bechberger J.F., MacFabe D., Guthrie N., Kurowska E.M., and Naus C.C. Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells. Carcinigenesis 28 (2007) 93-100
3. Contreras J.E., Sanchez H.A., Eugenin E.A., Speidel D., Theis M., Willecke K., et al. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A 99 (2002) 495-500
4. Chipman J.K., Mally A., and Edwards G.O. Disruption of gap junctions in toxicity and carcinogenicity. Toxicol Sci 71 (2003) 146-153
5. Evans W.H., and Martin P.E. Gap junctions: structure and function. Mol Membr Biol 19 (2002) 121-136
6. Fernstrom M.J., Koffler L.D., Abou-Rjaily G., Boucher P.D., Shewach D.S., and Ruch R.J. Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43. Exp Mol Pathol 73 (2002) 54-60
7. Flachon V., Tonoli H., Selmi-Ruby S., Durand C., Rabilloud R., Rousset B., et al. Thyroid cell proliferation in response to forced expression of gap junction proteins. Eur J Cell Biol 81 (2002) 243-252
8. + and cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts. J Biol Chem 276 (2001) 21642-21648
9. Hanna E.A., Umhauer S., Roshong S.L., Piechocki M.P., Fernstrom M.J., Fanning J.D., et al. Gap junctional intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro. Caicinogenesis 20 (1999) 1369-1373
10. Holder J.W., Elmore E., and Barrett J.C. Gap junction function and cancer. Cancer Res 53 (1993) 3475-3485
11. Hossain M.Z., Jagdale A.B., Ao P., LeCiel C., Huang R.P., and Boynton A.L. Impaired expression and posttranslational processing of connexin43 and downregulation of gap junctional communication in neoplastic human prostate cells. Prostate 38 (1999) 55-59
12. Hirschi K.K., Xu C.E., Tsukamoto T., and Sager R. Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ 7 (1996) 861-870
13. Huang R.P., Fan Y., Hossain M.Z., Peng A., Zeng Z.L., and Boynton A.L. Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res 58 (1998) 5089-5096
14. Huang R.P., Hossain M.Z., Sehgal A., and Boynton A.L. Reduced connexin43 expression in high-grade human brain glioma cells. J Surg Oncol 70 (1999) 21-24
15. Jiang J.X., and Gu S. Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta 1711 (2005) 208-214
16. John S.A., Kondo R., Wang S.Y., Goldhaber J.I., and Weiss J.N. Connexin-43 hemichannels opened by metabolic inhibition. J Biol Chem 274 (1999) 236-240
17. King T.J., and Bertram J.S. Connexins as targets for cancer chemoprevention and chemotherapy. Biochim Biophys Acta 1791 (2005) 146-160
18. King T.J., Fukushima L.H., Hieber A.D., Shimabukuro K.A., Sakr W.A., and Bertram J.S. Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Caicinogenesis 21 (2000) 1097-1109
19. Koffler L., Roshong S., Kyu Park I., Cesen-Cummings K., Thompson D.C., Dwyer-Nield L.D., et al. Growth inhibition in G(1) and altered expression of cyclin D1 and p27(kip-1)after forced connexin expression in lung and liver carcinoma cells. J Cell Biochem 79 (2000) 347-354
20. Kumar N.M., and Gilula N.B. The gap junction communication channel. Cell 84 (1996) 381-388
21. Lecanda F., Towler D.A., Ziambaras K., Cheng S.L., Koval M., Steinberg T.H., et al. Gap junctional communication modulates gene expression in osteoblastic cells. Mol Biol Cell 9 (1998) 2249-2258
22. Li Z., and Wang J. A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Cell Biol Int 30 (2006) 940-946
23. Li Z., Zhou Z., Saunders M.M., and Donahue H.J. Modulation of connexin43 alters expression of osteoblastic differentiation markers. Am J Physiol Cell Physiol 290 (2005) 1248-1255
24. Martin P.E., and Evans W.H. Incorporation of connexins into plasma membranes and gap junctions. Cardiovasc Res 62 (2004) 378-387
25. Martin T.J., Ingleton P.M., Underwood J.C., Michelangeli V.P., Hunt N.H., and Melick R.A. Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma. Nature 260 (1976) 436-438
26. Mesnil M., Krutovskikh V., Piccoli C., Elfgang C., Traub O., Willecke K., et al. Negative growth control of HeLa cells by connexin genes: connexin species specificity. Cancer Res 55 (1995) 629-639
27. Moorby C., and Patel M. Dual functions for connexins: Cx43 regulates growth independently of gap junction formation. Exp Cell Res 271 (2001) 238-248
28. Naus C.C., Elisevich K., Zhu D., Belliveau D.J., and Del Maestro R.F. In vivo growth of C6 glioma cells transfected with connexin43 cDNA. Cancer Res 52 (1992) 4208-4213
29. Ng K.W., Livesey S.A., Collier F., Gummer P.R., and Martin T.J. Effect of retinoids on the growth, ultrastructure, cytoskeletal structures of malignant rat osteoblasts. Cancer Res 45 (1985) 5106-5113
30. Proulx A.A., Lin Z.X., and Naus C.C. Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation. Cell Growth Differ 8 (1997) 533-540
31. Quist A.P., Rhee S.K., Lin H., and Lal R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J Cell Biol 148 (2000) 1063-1074
32. Rogers M., Berestecky J.M., Hossain M.Z., Guo H.M., Kadle R., Nicholson B.J., et al. Retinoid-enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein. Mol Carcinog 3 (1990) 335-343
33. Romanello M., Moro L., Pirulli D., Crovella S., and D'Andrea P. Effects of cAMP on intercellular coupling and osteoblast differentiation. Biochem Biophys Res Commun 282 (2001) 1138-1144
34. Sigler K., and Ruch R.J. Enhancement of gap junctional intercellular communication in tumor promoter-treated cells by components of green tea. Cancer Lett 69 (1993) 15-19
35. Stahl W., and Sies H. The role of carotenoids and retinoids in gap junctional communication. Int J Vitam Nutr Res 68 (1998) 354-359
36. Steinberg T.H., Civitelli R., Geist S.T., Robertson A.J., Hick E., Veenstra R.D., et al. Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. EMBO J 13 (1994) 744-750
37. Stout C.E., Costantin J.L., Naus C.C., and Charles A.C. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 277 (2002) 10482-10488
38. Tanmahasamut P., and Sidell N. Up-regulation of gap junctional intercellular communication and connexin43 expression by retinoic acid in human endometrial stromal cells. J Clin Endocrinol Metab 90 (2005) 4151-4156
39. Temme A., Buchmann A., Gabriel H.D., Nelles E., Schwarz M., and Willecke K. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol 7 (1997) 713-716
40. Valiunas V. Biophysical properties of connexin-45 gap junction hemichannels studied in vertebrate cells. J Gen Physiol 119 (2002) 147-164
41. Vine A.L., and Bertram J.S. Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs. Nutr Cancer 21 (2002) 199-204
42. Vinken M., Vanhaecke T., Papeleu P., Snykers S., Henkens T., and Rogiers V. Connexins and their channels in cell growth and cell death. Cell Signal 18 (2006) 592-600
43. Weinberg R.A. Tumor suppressor genes. Science 254 (1991) 1138-1146
44. Yamasaki H., and Naus C.C. Role of connexin genes in growth control. Caicinogenesis 17 (1996) 1199-1213
45. Yano T., and Yamasaki H. Regulation of cellular invasion and matrix metalloproteinase activity in HepG2 cell by connexin 26 transfection. Mol Carcinog 31 (2001) 101-109
46. Ye J., and Wang J. CF mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin D1 expression in human hepatoma HepG2 cells. Hepatol Res 35 (2006) 88-95
47. Yen A., Roberson M.S., Varvayanis S., and Lee A.T. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res 58 (1998) 3163-3171
48. Zhang L.X., Cooney R.V., and Bertram J.S. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 12 (1991) 2109-2114
49. Zhang L.X., Cooney R.V., and Bertram J.S. Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 52 (1992) 5707-5712
50. Zhang Y.W., Kaneda M., and Morita I. The gap junction-independent tumor-suppressing effect of connexin 43. J Biol Chem 278 (2003) 44852-44856
51. Zhang Y.W., Morita I., Ikeda M., Ma K.W., and Murota S. Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. Oncogene 20 (2001) 4138-4149
52. Zhang Y.W., Nakayama K., Nakayama K., and Morita I. A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2). Cancer Res 63 (2003) 1623-1630