Association between Inflammation-Associated Cytokines, Serum Albumins, and Mortality in the Elderly

Journal of the American Medical Directors Association

Volumn 8, Issue 7, 2007, Pages 458-463

  Sullivan, Dennis H ^a,b   Roberson, Paula K ^c   Johnson, Larry E ^b,d   Mendiratta, Priya ^b   Bopp, Melinda M ^b   Bishara, Osama ^e  

^a GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d Central Arkansas Veterans Healthcare System Little   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

albumin; Elderly; inflammatory cytokines; mortality; protein energy undernutrition

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PREALBUMIN; SERUM ALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GERIATRIC CARE; GERIATRIC PATIENT; GERIATRIC REHABILITATION; HOSPITAL ADMISSION; HOSPITAL DEPARTMENT; HOSPITAL DISCHARGE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT SELECTION; PREDICTION; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; UNIVERSITY HOSPITAL;

EID: 34548420600     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2007.04.004     Document Type: Article

References (21)

1. Goldwasser P., and Feldman J. Association of serum albumin and mortality risk. J Clin Epidemiol 50 6 (1997) 693-703
2. Sullivan D.H., Roberson P.K., and Bopp M.M. Hypoalbuminemia 3 Months after hospital discharge: Significance for long-term survival. J Am Geriatr Soc 53 7 (2005) 1222-1226
3. Rothschild M.A., Oratz M., and Schreiber S.S. Serum albumin. Hepatology 8 (1988) 385-401
4. Doweiko J.P., and Nompleggi D.J. Role of albumin in human physiology and pathophysiology. JPEN J Parenter Enteral Nutr 15 (1991) 207-211
5. Doweiko J.P., and Nompleggi D.J. The role of albumin in human physiology and pathophysiology, Part III: Albumin and disease states. JPEN J Parenter Enteral Nutr 15 (1991) 476-483
6. Puskarich-May C.L., Sullivan D.H., Nelson C.L., et al. The change in serum protein concentration in response to the stress of total joint surgery: a comparison of older versus younger patients. J Am Geriatr Soc 44 (1996) 555-558
7. Hoye R.C., Bennett S.H., Geelhoed G.W., et al. Fluid volume and albumin kinetics occurring with major surgery. JAMA 222 10 (1972) 1255-1261
8. Johnson A.M. Low levels of plasma proteins: Malnutrition or inflammation?. Clin Chem Lab Med 37 2 (1999) 91-96
9. Gabay C., and Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340 6 (1999) 448-454
10. Sullivan D.H., and Walls R.C. The risk of life-threatening complications in a select population of geriatric patients: The impact of nutritional status. J Am Coll Nutr 1 (1995) 29-36
11. Reuben D.B., Ferrucci L., Wallace R., et al. The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels. J Am Geriatr Soc 48 11 (2000) 1404-1407
12. Katz S., Ford A.B., Moskowitz R.W., et al. Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychosocial function. JAMA 185 12 (1963) 914-919
13. Morgan E., Varro R., Sepulveda H., et al. Cytometric bead array: A multiplexed assay platform with applications in various areas of biology. Clin Immunol 110 3 (2004) 252-266
14. Camilla C., Mely L., Magnan A., et al. Flow cytometric microsphere-based immunoassay: Analysis of secreted cytokines in whole-blood samples from asthmatics. Clin Diagn Lab Immunol 8 4 (2001) 776-784
15. Carson R., and Vignali D. Simultaneous quantitation of fifteen cytokines using a multiplexed flow cytometric assay. J Immunol Methods 227 (1999) 41-52
16. Simovic M.O., Bonham M.J., bu-Zidan F.M., et al. Anti-inflammatory cytokine response and clinical outcome in acute pancreatitis. Crit Care Med 27 12 (1999) 2662-2665
17. Sullivan D.H., and Walls R.C. Protein-energy undernutrition and the risk of mortality within six years of hospital discharge. J Am Coll Nutr 17 6 (1998) 571-578
18. Charlson M.E., Pompei P., Ales K.L., et al. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 40 (1987) 373-383
19. Rudman D., Feller A.G., Nagraj H.S., et al. Relation of serum albumin concentration to death rate in nursing home men. JPEN J Parenter Enteral Nutr 11 (1987) 360-363
20. Bernstein L., and Prealbumin in Nutritional Care Consensus Group. Measurement of visceral protein status in assessing protein and energy malnutrition: Standard of care. Nutrition 11 2 (1995) 169-171
21. Hasegawa Y., Sawada M., Ozaki N., et al. Increased soluble tumor necrosis factor receptor levels in the serum of elderly people. Gerontology 46 4 (2000) 185-188