A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm

PLoS Computational Biology

Volumn 3, Issue 8, 2007, Pages 1633-1647

  Gurkiewicz, Meron ^a   Korngreen, Alon ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; IONS; KINETIC PARAMETERS; MARKOV PROCESSES; NEURONS; PARAMETER ESTIMATION; POTASSIUM; PROTEINS; SODIUM;

CELL VOLTAGES; CHANNEL KINETICS; CHANNEL MODELLING; ION CHANNEL; NUMERICAL APPROACHES; SINGLE CHANNEL RECORDING; SODIUM CHANNEL; TRANS-MEMBRANE PROTEINS; VOLTAGE CLAMP; WHOLE CELL;

GENETIC ALGORITHMS;

VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; ION CHANNEL;

ACCURACY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENETIC ALGORITHM; HODGKIN HUXLEY EQUATION; KINETICS; MATHEMATICAL COMPUTING; NONHUMAN; POTASSIUM CURRENT; PROBABILITY; RAT; SODIUM CURRENT; STIMULATION; VOLTAGE CLAMP; WHOLE CELL; ACTION POTENTIAL; ALGORITHM; BIOLOGICAL MODEL; CELL MEMBRANE; CHANNEL GATING; COMPUTER SIMULATION; MEMBRANE POTENTIAL; NERVE CELL; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

RATTUS;

ACTION POTENTIALS; ALGORITHMS; CELL MEMBRANE; COMPUTER SIMULATION; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MODELS, GENETIC; MODELS, NEUROLOGICAL; NEURONS; SYNAPTIC TRANSMISSION;

EID: 34548403017     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0030169     Document Type: Article

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