Cardiac output and leg and arm blood flow during incremental exercise to exhaustion on the cycle ergometer

Journal of Applied Physiology

Volumn 103, Issue 3, 2007, Pages 969-978

  Calbet, Jose A L ^a,b,f   Gonzalez Alonso, Jose ^b,e   Helge, Jörn W ^b,c   Søndergaard, Hans ^b   Munch Andersen, Thor ^b   Boushe, Robert ^c,d   Saltin, Bengt ^b  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Gina Cody School of Engineering and Computer Science   (Canada)

^e BRUNEL UNIVERSITY   (United Kingdom)

^f Campus Univ de Tafira   (Spain)

Author keywords

Fatigue; Oxygen extraction; Performance; Sympatholysis

Indexed keywords

ADULT; ARM BLOOD FLOW; ARTICLE; CONTROLLED STUDY; ERGOMETER; EXERCISE; HEART OUTPUT; HUMAN; MALE; NORMAL HUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; VEIN BLOOD FLOW;

ADULT; ARM; BLOOD PRESSURE; CARDIAC OUTPUT; ELECTROLYTES; EXERCISE; EXERCISE TEST; HEMODYNAMICS; HUMANS; LEG; MALE; OXYGEN; REGIONAL BLOOD FLOW; VASODILATION;

EID: 34548401590     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01281.2006     Document Type: Article

References (63)

1. Aaker A, Laughlin MH. Diaphragm arterioles are less responsive to α1-adrenergic constriction than gastrocnemius arterioles. J Appl Physiol 92: 1808-1816, 2002.
2. Andersen P, Adams RP, Sjøgaard G, Thorboe A, Saltin B. Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59: 1647-1653, 1985.
3. Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol 366: 233-249, 1985.
4. Bergfeld GR, Forrester T. Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res 26: 40-47, 1992.
5. Bevegard BS, Shepherd JT. Reaction in man of resistance and capacity vessels in forearm and hand to leg exercise. J Appl Physiol 21: 123-132, 1966.
6. Boushel R, Calbet JA, Radegran G, Sondergaard H, Wagner PD, Saltin B. Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation 104: 1785-1791, 2001.
7. Buehler PW, Alayash AI. Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature. Antioxid Redox Signal 6: 1000-1010, 2004.
8. Calbet JA. Oxygen tension and content in the regulation of limb blood flow. Acta Physiol Scand 168: 465-472, 2000.
9. Calbet JA, Holmberg HC, Rosdahl H, van Hall G, Jensen-Urstad M, Saltin B. Why do arms extract less oxygen than legs during exercise? Am J Physiol Regul Integr Comp Physiol 289: R1448-R1458, 2005.
10. Calbet JA, Jensen-Urstad M, Van Hall G, Holmberg HC, Rosdahl H, Saltin B. Maximal muscular vascular conductances during whole body upright exercise in humans. J Physiol 558: 319-331, 2004.
11. Calbet JA, Lundby C, Koskolou M, Boushel R. Importance of hemoglobin concentration to exercise: acute manipulations. Respir Physiol Neurobiol 151: 132-140, 2006.
12. 2 extraction during maximal exercise in humans. Am J Physiol Regul Integr Comp Physiol 291: R447-R453, 2006.
13. Callister R, Ng AV, Seals DR. Arm muscle sympathetic nerve activity during preparation for and initiation of leg-cycling exercise in humans. J Appl Physiol 77: 1403-1410, 1994.
14. Clifford PS, Hellsten Y. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97: 393-403, 2004.
15. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9: 1498-1505, 2003.
16. Delp MD, O'Leary DS. Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exercise. J Appl Physiol 97: 1112-1118, 2004.
17. Dempsey JA, Romer L, Rodman J, Miller J, Smith C. Consequences of exercise-induced respiratory muscle work. Respir Physiol Neurobiol 151: 242-250, 2006.
18. Dempsey JA, Sheel AW, St Croix CM, Morgan BJ. Respiratory influences on sympathetic vasomotor outflow in humans. Respir Physiol Neurobiol 130: 3-20, 2002.
19. Dinenno FA, Joyner MJ. Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory? J Physiol 553: 281-292, 2003.
20. Dow P. Estimations of cardiac output and central blood volume by dye dilution. Physiol Rev 36: 77-102, 1956.
21. Ellsworth ML, Forrester T, Ellis CG, Dietrich HH. The erythrocyte as a regulator of vascular tone. Am J Physiol Heart Circ Physiol 269: H2155-H2161, 1995.
22. Esler M, Jennings G, Leonard P, Sacharias N, Burke F, Johns J, Blombery P. Contribution of individual organs to total noradrenaline release in humans. Acta Physiol Scand Suppl 527: 11-16, 1984.
23. Grubbstrom J, Berglund B, Kaijser L. Myocardial oxygen supply and lactate metabolism during marked arterial hypoxaemia. Acta Physiol Scand 149: 303-310, 1993.
24. Hansen J, Sander M, Thomas GD. Metabolic modulation of sympathetic vasoconstriction in exercising skeletal muscle. Acta Physiol Scand 168: 489-503, 2000.
25. Harms CA, Babcock MA, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Dempsey JA. Respiratory muscle work compromises leg blood flow during maximal exercise. J Appl Physiol 82: 1573-1583, 1997.
26. 2peak and left ventricular systolic function in recent cardiac transplant recipients. Am J Cardiol 95: 1002-1004, 2005.
27. Hilton SM, Jeffries MG, Vrbova G. Functional specializations of the vascular bed of soleus. J Physiol 206: 543-562, 1970.
28. Jacob G, Costa F, Shannon J, Robertson D, Biaggioni I. Dissociation between neural and vascular responses to sympathetic stimulation: contribution of local adrenergic receptor function. Hypertension 35: 76-81, 2000.
29. 2 delivery mediated by hemoglobin oxygenation. Am J Physiol Heart Circ Physiol 280: H2833-H2839, 2001.
30. Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380: 221-226, 1996.
31. Keller DM, Ogoh S, Greene S, Olivencia-Yurvati A, Raven PB. Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle. J Physiol 561: 273-282, 2004.
32. Kjellmer I. On the competition between metabolic vasodilatation and neurogenic vasoconstriction in skeletal muscle. Acta Physiol Scand 63: 450-459, 1965.
33. Laughlin MH, Armstrong RB. Adrenoreceptor effects on rat muscle blood flow during treadmill exercise. J Appl Physiol 62: 1465-1472, 1987.
34. Lee F, Shoemaker JK, McQuillan PM, Kunselman AR, Smith MB, Yang QX, Smith H, Gray K, Sinoway LI. Effects of forearm bier block with bretylium on the hemodynamic and metabolic responses to handgrip. Am J Physiol Heart Circ Physiol 279: H586-H593, 2000.
35. Mortensen SP, Dawson EA, Yoshiga CC, Dalsgaard MK, Damsgaard R, Secher NH, Gonzalez-Alonso J. Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans. J Physiol 566: 273-285, 2005.
36. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN. Different vasodilator responses of human arms and legs. J Physiol 556: 1001-1011, 2004.
37. Nielsen HB, Clemmesen JO, Skak C, Ott P, Secher NH. Attenuated hepatosplanchnic uptake of lactate during intense exercise in humans. J Appl Physiol 92: 1677-1683, 2002.
38. Pawelczyk JA, Levine BD. Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect? J Appl Physiol 92: 2105-2113, 2002.
39. Ra°degran G, Blomstrand E, Saltin B. Peak muscle perfusion and oxygen uptake in humans: importance of precise estimates of muscle mass. J Appl Physiol 87: 2375-2380, 1999.
40. Ra°degran G, Saltin B. Human femoral artery diameter in relation to knee extensor muscle mass, peak blood flow, and oxygen uptake. Am J Physiol Heart Circ Physiol 278: H162-H167, 2000.
41. Remensnyder JP, Mitchell JH, Sarnoff SJ. Functional sympatholysis during muscular activity. Observations on influence of carotid sinus on oxygen uptake. Circ Res 11: 370-380, 1962.
42. Richardson RS, Kennedy B, Knight DR, Wagner PD. High muscle blood flows are not attenuated by recruitment of additional muscle mass. Am J Physiol Heart Circ Physiol 269: H1545-H1552, 1995.
43. 2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am J Physiol Heart Circ Physiol 276: H438-H445, 1999.
44. Rosenmeier JB, Hansen J, Gonzalez-Alonso J. Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J Physiol 558: 351-365, 2004.
45. 2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 100: 744-748, 2006.
46. Saltin B, Kiens B, Savard G, Pedersen PK. Role of hemoglobin and capillarization for oxygen delivery and extraction in muscular exercise. Acta Physiol Scand Suppl 556: 21-32, 1986.
47. Savard G, Strange S, Kiens B, Richter EA, Christensen NJ, Saltin B. Noradrenaline spillover during exercise in active versus resting skeletal muscle in man. Acta Physiol Scand 131: 507-515, 1987.
48. Savard GK, Areskog NH, Saltin B. Cardiovascular response to exercise in humans following acclimatization to extreme altitude. Acta Physiol Scand 154: 499-509, 1995.
49. Seals DR. Influence of muscle mass on sympathetic neural activation during isometric exercise. J Appl Physiol 67: 1801-1806, 1989.
50. Secher NH, Clausen JP, Klausen K, Noer I, Trap-Jensen J. Central and regional circulatory effects of adding arm exercise to leg exercise. Acta Physiol Scand 100: 288-297, 1977.
51. Sheel AW, Derchak PA, Pegelow DF, Dempsey JA. Threshold effects of respiratory muscle work on limb vascular resistance. Am J Physiol Heart Circ Physiol 282: H1732-H1738, 2002.
52. Singel DJ, Stamler JS. Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin. Annu Rev Physiol 67: 99-145, 2005.
53. Stenberg J, Astrand PO, Ekblom B, Royce J, Saltin B. Hemodynamic response to work with different muscle groups, sitting and supine. J Appl Physiol 22: 61-70, 1967.
54. Strange S. Cardiovascular control during concomitant dynamic leg exercise and static arm exercise in humans. J Physiol 514: 283-291, 1999.
55. Strange S, Rowell LB, Christensen NJ, Saltin B. Cardiovascular responses to carotid sinus baroreceptor stimulation during moderate to severe exercise in man. Acta Physiol Scand 138: 145-153, 1990.
56. Sundberg CJ, Kaijser L. Effects of graded restriction of perfusion on circulation and metabolism in the working leg; quantification of a human ischaemia-model. Acta Physiol Scand 146: 1-9, 1992.
57. Tanaka H, Shimizu S, Ohmori F, Muraoka Y, Kumagai M, Yoshizawa M, Kagaya A. Increases in blood flow and shear stress to nonworking limbs during incremental exercise. Med Sci Sports Exerc 38: 81-85, 2006.
58. Thomas GD, Hansen J, Victor RG. ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. J Clin Invest 99: 2602-2609, 1997.
59. Thomas GD, Segal SS. Neural control of muscle blood flow during exercise. J Appl Physiol 97: 731-738, 2004.
60. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z, Joyner MJ. Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541: 623-635, 2002.
61. VanTeeffelen JW, Segal SS. Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscle. J Physiol 550: 563-574, 2003.
62. Volianitis S, Secher NH. Arm blood flow and metabolism during arm and combined arm and leg exercise in humans. J Physiol 544: 977-984, 2002.
63. Volianitis S, Yoshiga CC, Nissen P, Secher NH. Effect of fitness on arm vascular and metabolic responses to upper body exercise. Am J Physiol Heart Circ Physiol 286: H1736-H1741, 2004.