The effectiveness of antidepressant medication in the management of behaviour problems in adults with intellectual disabilities: A systematic review

Journal of Intellectual Disability Research

Volumn 51, Issue 10, 2007, Pages 750-765

  Sohanpal, S K ^a   Deb, Shoumitro ^a   Thomas, C ^a   Soni, R ^a   Lenotre L ^a   Unwin, G ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adults; Anmtidespressants; Behavior problem; Intellectual disabilities; Systematic review

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE; CLOMIPRAMINE; FLUOXETINE; FLUVOXAMINE; NEUROLEPTIC AGENT; PAROXETINE; PLACEBO; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADD ON THERAPY; ADULT; AGGRESSION; AGITATION; ANOREXIA; ANXIETY DISORDER; AUTOMUTILATION; BEHAVIOR DISORDER; BEHAVIOR THERAPY; CINAHL; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; COHORT ANALYSIS; DISEASE ASSOCIATION; DROWSINESS; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ERUPTION; DRUG RESPONSE; DRUG WITHDRAWAL; EMBASE; EVIDENCE BASED MEDICINE; FOLLOW UP; HUMAN; HYPOMANIA; INFORMATION RETRIEVAL; INSOMNIA; INTELLECTUAL IMPAIRMENT; MALADJUSTMENT; MEDLINE; OBSESSIVE COMPULSIVE DISORDER; OUTCOMES RESEARCH; PSYCINFO; REVIEW; SEIZURE; SIDE EFFECT; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VOMITING; WEIGHT REDUCTION;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS; HUMANS; MENTAL DISORDERS; MENTAL RETARDATION; SELF-INJURIOUS BEHAVIOR;

EID: 34548392124     PISSN: 09642633     EISSN: 13652788     Source Type: Journal    
DOI: 10.1111/j.1365-2788.2006.00935.x     Document Type: Review

References (32)

1. Barak Y., Ring A., Levy D., Granek I., Szor H. & Elizur A. (1995) Disabling compulsions in 11 mentally retarded adults: An open trial of clomipramine SR. Journal of Clinical Psychiatry 56, 459-61.
2. Berman A. L. (1992) Treating suicidal behavior in the mentally retarded: the case of Kim. Suicide and Life-Threatening Behavior 22, 504-6; discussion 506-12.
3. British National Formulary 50 (September 2005) British Medical Association & Royal Pharmaceutical Society, London.
4. Bodfish J. W. & Madison J. T. (1993) Diagnosis and fluoxetine treatment of compulsive behavior disorder of adults with mental retardation. American Journal on Mental Retardation 98, 360-7.
5. Branford D., Bhaumik S. & Naik B. (1998) Selective serotonin re-uptake inhibitors for the treatment of perseverative and maladaptive behaviours of people with intellectual disability. Journal of Intellectual Disability Research 42, 301-6.
6. Brylewski J. & Duggan L. (2004) Antipsychotic medication for challenging behaviour in people with learning disability. In: The Cochrane Database of Systematic Reviews Issue 3. John Wiley & Sons, Ltd., Chicester, UK.
7. Carr E. G., Horner R. H. & Turnbull A. P. (1999) Positive Behaviour Support for People with Developmental Disabilities: A Research Synthesis. American Association on Mental Retardation, Washington, DC.
8. Cassidy S. B. (1992) Prozac use to manage behaviour in a Prader-Willi syndrome population. Dysmorphology and Clinical Genetics 6, 76.
9. Clarke D. J., Kelley S., Thinn K. & Corbett J. A. (1990) Psychotropic drugs and mental retardation: 1. Disabilities and the prescription of drugs for behaviour and for epilepsy in 3 residential settings. Journal of Mental Deficiency Research 28, 229-33.
10. Cook E. H. Jr, Rowlett R., Jaselskis C. & Leventhal B. L. (1992) Fluoxetine treatment of children and adults with autistic disorder and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry 31, 739-45.
11. Davanzo P. A., Belin T. R., Widawski M. H. & King B. H. (1998) Paroxetine treatment of aggression and self-injury in persons with mental retardation. American Journal on Mental Retardation 102, 427-37.
12. Deb S. & Fraser W. (1994) The use of psychotropic medication in people with learning disability: Towards rational prescribing. Human Psychopharmacology 9, 259-72.
13. Deb S., Thomas M. & Bright C. (2001) Mental disorder in adults with intellectual disability. 2: The rate of behaviour disorders among a community-based population aged between 16 and 64 years. Journal of Intellectual Disability Research 45, 506-14.
14. Duker P. C., Welles K., Seys D., Rensen H., Vis A. & Van den Berg G. (1991) Brief report: Effects of fenfluramine on communicative, stereotypic, and inappropriate behaviours of autistic-type mentally handicapped individuals. Journal of Autism and Developmental Disorders 21, 355-63.
15. Friedman E. H. (1996) Fluoxetine and aggressive behaviour. Pharmacopsychiatry 29, 121.
16. Hagerman R. J., Fulton M. J., Leaman A., Riddle J., Hagerman K. & Sobesky W. (1994) A survey of fluoxetine therapy in fragile X syndrome. Developmental Brain Dysfunction 7, 155-64.
17. Janowsky D. S., Shetty M., Barnhill J., Elamir B. & Davis J. M. (2005) Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: A retrospective, open-label, naturalistic trial. International Journal of Neuropsychopharmacology 8, 37-48.
18. La Malfa G. P., Bertelli M., Ricca V., Mannucci E. & Cabras P. L. (1997) Fluvoxamine and mental retardation: Clinical use. Italian Journal of Intellective Impairment 10, 3-6.
19. La Malfa G. P., Bertelli M. & Conte M. (2001) Fluvoxamine and aggression in mental retardation. Psychiatric Services 52, 1105.
20. Langee H. R. & Conlon M. (1992) Predictors of response to antidepressant medications. American Journal on Mental Retardation 97, 65-70.
21. Lewis M. H., Bodfish J. W., Powell S. B. & Golden R. N. (1995) Clomipramine treatment for stereotype and related repetitive movement disorders associated with mental retardation. American Journal on Mental Retardation 100, 299-312.
22. McDougle C. J., Naylor S. T., Cohen D. J., Volkmar F. R., Heninger G. R. & Price L. H. (1996) A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Archives of General Psychiatry 53, 1001-8.
23. McDougle C. J., Brodkin E. S., Naylor S. T., Carlson D. C., Cohen D. J. & Price L. H. (1998) Sertraline in adults with pervasive developmental disorders: A prospective open-label investigation. Journal of Clinical Psychopharmacology 18, 62-6.
24. Markowitz P. I. (1990) Fluoxetine treatment of self-injurious behaviour in mentally retarded patients. Journal of Clinical Psychopharmacology 10, 299-300.
25. Markowitz P. I. (1992) Effect of fluoxetine on self-injurious behavior in the developmentally disabled: A preliminary study. Journal of Clinical Psychopharmacology 12, 27-31.
26. Posey D. J., Guenin K. D., Kohn A. E., Swiezy N. B. & McDougle C. J. (2001) A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology 11, 267-77.
27. Singh A. N., Kleynhans D. & Barton G. (1998) Selective serotonin re-uptake inhibitors in the treatment of self-injurious behaviour in adults with mental retardation. Human Psychopharmacology 13, 267-70.
28. Smith S., Branford D., Collacott R., Cooper S. A. & McGrother C. (1996) Prevalence and cluster typology of maladaptive behaviours in a geographically defined population of adults with leaning disabilities. British Journal of Psychiatry 169, 219-27.
29. Troisi A., Vicario E., Nuccetelli F., Ciani N. & Pasini A. (1995) Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy. Pharmacopsychiatry 28, 73-6.
30. Tsiouris J. A., Cohen I. L., Patti P. J. & Korosh W. M. (2003) Treatment of previously undiagnosed psychiatric disorders in persons with developmental disabilities decreased or eliminated self-injurious behavior. Journal of Clinical Psychiatry 64, 1081-90.
31. Vanden Borre R., Vermote R., Buttiens M., Thiry P., Dierick G., Geutjens J., Sieben G. & Heylen S. (1993) Risperidone as add-on therapy in behavioural disturbances in mental retardation: A double-blind placebo-controlled crossover study. Acta Psychiatrica Scandinavica 87, 167-71.
32. Verhoeven W. M. A., Veendrik-Meekes M. J., Jacobs G. A. J., van den Berg Y. W. M. M. & Tuinier B. S. (2001) Citalopram in mentally retarded patients with depression: A long-term clinical investigation. European Psychiatry 16, 104-8.