Regulation of human MC2-R gene expression by CREB, CREM, and ICER in the adrenocortical cell line Y1

Hormone and Metabolic Research

Volumn 39, Issue 8, 2007, Pages 560-566

  Zwermann, O ^a   Braun, A C ^b   Lalli, E ^c   Sassone Corsi, P ^d   Beuschlein, F ^b   Reincke, M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c CNRS   (France)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

ACTH receptor; ACTH receptor promoter; Adrenal; Corticotropin; Corticotropin receptor expression

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; FORSKOLIN; LUCIFERASE; MELANOCORTIN 2 RECEPTOR; PROTEIN ICER; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADRENAL CORTEX; ANIMALS; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT MODULATOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FORSKOLIN; GENE EXPRESSION REGULATION; HUMANS; MICE; PROMOTER REGIONS (GENETICS); RECEPTOR, MELANOCORTIN, TYPE 2; TRANSFECTION;

EID: 34548371826     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-985141     Document Type: Article

References (32)

1. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encode the melanocortin receptors. Science 1992; 257: 1248-1251
2. Lotfi CF, Todorovic Z, Armelin HA, Schimmer BP. Unmasking a growth-promoting effect of the adrenocorticotropic hormone in Y1 mouse adrenocortical tumor cells. J Biol Chem 1997; 272: 29886-29891
3. Gallo-Payet N, Payet MD. Mechanism of action of ACTH: beyond cAMP. Microsc Res Tech 2003; 61: 275-287
4. Mountjoy KG, Bird IM, Rainey WE, Cone RD. ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines. Mol Cell Endocrinol 1994; 99: R17-R20
5. Naville D, Jaillard C, Barjhoux L, Durand P, Begeot M. Genomic structure and promoter characterization of the human ACTH receptor gene. Biochem Biophys Res Commun 1997; 230: 7-12
6. Marchal R, Naville D, Durand P, Begeot M, Penhoat A. A steroidogenic factor-1 binding element is essential for basal human ACTH receptor gene transcription. Biochem Biophys Res Commun 1998; 247: 28-32
7. Naville D, Penhoat A, Durand P, Begeot M. Three steroidogenic factor-1 binding elements are required for constitutive and cAMP-regulated expression of the human adrenocorticotropin receptor gene. Biochem Biophys Res Commun 1999; 255: 28-33
8. Sarkar D, Kambe F, Hayashi Y et al. Involvement of AP-1 and steroidogenic factor (SF)-1 in the cAMP-dependent induction of human adrenocorticotropic hormone receptor (ACTHR) promoter. Endocr J 2000; 47: 63-75
9. Naville D, Bordet E, Berthelon MC, Durand P, Begeot M. Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription. Eur J Biochem 2001; 268: 1802-1810
10. Craig JC, Schumacher MA, Mansoor SE et al. Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. J Biol Chem 2001; 276: 11719-11728
11. Fink JS, Verhave M, Kasper S et al. The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer. Proc Natl Acad Sci USA 1988; 85: 6662-6666
12. Fimia GM, Cesare D De, Sassone-Corsi P. CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature 1999; 398: 165-169
13. Foulkes NS, Mellstrom B, Benusiglio E, Sassone-Corsi P. Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature 1992; 355: 80-84
14. Mazzucchelli C, Sassone-Corsi P. The inducible cyclic adenosine monophosphate early repressor (ICER) in the pituitary intermediate lobe: role in the stress response. Mol Cell Endocrinol 1999; 155: 101-113
15. Nantel F, Sassone-Corsi P. CREM: a transcriptional master switch during the spermatogenesis differentiation program. Front Biosci 1996; 1: d266-d269
16. Foulkes NS, Duval G, Sassone-Corsi P. Adaptive inducibility of CREM as transcriptional memory of circadian rhythms. Nature 1996; 381: 83-85
17. Molina CA, Foulkes NS, Lalli E, Sassone-Corsi P. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 1993; 75: 875-886
18. Della Fazia MA, Servillo G, Foulkes NS, Sassone-Corsi P. Stress-induced expression of transcriptional repressor ICER in the adrenal gland. FEBS Lett 1998; 434: 33-36
19. Delmas V, Hoorn F van der, Mellstrom B, Jegou B, Sassone-Corsi P. Induction of CREM activator proteins in spermatids: down-stream targets and implications for haploid germ cell differentiation. Mol Endocrinol 1993; 7: 1502-1514
20. Oetjen E, Diedrich T, Eggers A, Eckert B, Knepel W. Distinct properties of the cAMP-responsive element of the rat insulin I gene. J Biol Chem 1994; 269: 27036-27044
21. Lynch JP, Lala DS, Peluso JJ et al. Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol 1993; 7: 776-786
22. Gonzalez GA, Yamamoto KK, Fischer WH et al. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 1989; 337: 749-752
23. Penhoat A, Jaillard C, Saez JM. Regulation of bovine adrenal cell corticotropin receptor mRNA levels by corticotropin (ACTH) and angiotensin-II (A-II). Mol Cell Endocrinol 1994; 103: R7-R10
24. Quandt K, Freeh K, Karas H, Wingender E, Werner T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995; 23: 4878-4884
25. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001; 2: 599-609
26. Groussin L, Massias JF, Bertagna X, Bertherat J. Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory overexpression of the activator CREMtau in the human adrenocortical cancer cell line H295R. J Clin Endocrinol Metab 2000; 85: 345-354
27. Manna PR, Dyson MT, Eubank DW et al. Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol 2002; 16: 184-199
28. Clem BF, Hudson EA, Clark BJ. Cyclic Adenosine 3′,5′-Monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse Steroidogenic Acute Regulatory (StAR) protein gene promoter. Endocrinology 2005; 146: 1348-1356
29. Winnay JN, Hammer GD. ACTH-mediated signaling cascades coordinate a cyclic pattern of SF-1-dependent transcriptional activation. Mol Endocrinol 2005; 18: 18
30. Sewer MB, Waterman MR. CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells. J Biol Chem 2003; 278: 8106-8111
31. Sewer MB, Waterman MR. ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex. Microsc Res Tech 2003; 61: 300-307
32. Ozbay T, Merrill Jr AH. Sewer MB ACTH regulates steroidogenic gene expression and Cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. Endocr Res 2004; 30: 787-794