Modeling mixtures resulting from concurrent exposures to multiple sources

Toxicology and Applied Pharmacology

Volumn 223, Issue 2, 2007, Pages 121-124

  Arnold, Susan F ^a   Price, Paul S ^a  

^a NONE   (United States)

Author keywords

Exposure assessment; Longitudinal; Mixtures; Multiple chemicals; Person oriented models

Indexed keywords

ENVIRONMENTAL CHEMICAL; PESTICIDE; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON; TOXIC SUBSTANCE;

AIR POLLUTANT; ARTICLE; CHEMICAL ANALYSIS; DANGEROUS GOODS; DIET; DRUG EXPOSURE; FLUID INTAKE; HUMAN; MEDICAL RESEARCH; METHODOLOGY; MODEL; RISK ASSESSMENT; SIMULATION; TECHNIQUE; TOXICITY;

ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; HUMANS; MODELS, THEORETICAL; RISK ASSESSMENT;

EID: 34548317566     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.11.032     Document Type: Article

References (12)

1. EPA, 2000a. Proposed guidance on cumulative risk assessment of pesticides chemicals having a common mechanism of toxicity. June 22, 2999. U.S. EPA, OPP, Washington, D.C.
2. EPA. Voluntary children's chemical evaluation program federal register December 26 (65). Num. 248 (2000) 81699-81718
3. EPA, 2001. General principles for performing aggregate exposure and risk assessments, Office of Pesticide Programs (www.epa.gov/pesticides/trac/science/aggregate.pdf).
4. EPA, 2003. Total Risk Integrated Methodology, TRIM ExpoInhalation User's Document Volume I: Air Pollutants Exposure Model (APEX, version 3), User's Guide Office of Air Quality Planning and Standards, Draft April 24, 2003.
5. ILSI. In: Olin S. (Ed). Aggregate Exposure a Report to EPA/ILSI Workshop (1998), ILSI Press, Washington, DC
6. ILSI. In: Mileson B., Faustman E., Olin S., Ryan P., Ferenc S., and Burke T. (Eds). A Framework for Cumulative Risk Assessment, An ILSI Risk Science Institute Workshop Report (1999) Washington D.C.
7. LifeLine 2004. Designing exposure models that support PBPK/PBPD models of cumulative risk prepared for USEPA Office Pesticide Programs Under EPA Contract EP-W-04-016. In partial fulfillment Work Assignment 1-4 "Technical Support and Model Enhancement for LifeLine Software" Prepared by Paul S. Price, Christine F. Chaisson, Claire A. Franklin, Michael A. Jayjock The LifeLine Group Inc. www.TheLifeLinegroup.org November 8, 2004.
8. Price P.S., and Chaisson C.F. A conceptual framework for modeling aggregate and cumulative exposures to chemicals manuscript. J. Exp. Anal. Environ. Epid. (2005). Advanced Online Publication 27 April 2005 10.1038/sj.jea.7500425
9. Price P.S., Curry C.L., Goodrum P.E., Gray M.N., McCrodden J.I., Harrington N.W., Carlson-Lynch H., and Keenan R.E. Monte Carlo modeling of time-dependent exposures using a microexposure event approach. Risk Anal. 16 3 (1996) 339-348
10. Price, P., Chaisson, C., Koontz, M., Wilkes, C., Ryan, P., Macintosh, D., Georgopoulos, P. (2003a). Construction of a comprehensive chemical exposure framework using person oriented modeling. Exposure Technical Implementation Panel American Chemistry Council Contract # 1388 http://www.thelifelinegroup.org/report.html.
11. Price P.S., Conolly R.B., Chaisson C.F., Young J.S., Mathis E.T., and Tedder D.T. Modeling inter-individual variation in physiological factors used in PBPK models of humans. Crit. Rev. Toxicol. 33 5 (2003) 469-503
12. Zartarian V.G., Özkaynak H., Burke J.M., Zufall M.J., Rigas M.L., and Furtaw Jr. E.J. A modeling framework for estimating children's residential exposure and dose to chlorpyrifos via dermal residue contact and nondietary ingestion. Environ. Health Perspect. 108 Number 6 (2000)