Chronic valproic acid intoxication: Reversal by naloxone

Emergency Medicine Journal

Volumn 24, Issue 9, 2007, Pages 677-678

  Thanacoody, H K Ruben ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CIPROFLOXACIN; FUROSEMIDE; NALOXONE; OLANZAPINE; RAMIPRIL; SIMVASTATIN; UREA; VALPROIC ACID;

AGED; ANAMNESIS; APNEA; ARTICLE; ARTIFICIAL HEART PACEMAKER; BACTERIUM CULTURE; BIPOLAR DEPRESSION; CASE REPORT; CLINICAL EXAMINATION; COMPLETE HEART BLOCK; CONFUSION; CONSCIOUSNESS DISORDER; CONVALESCENCE; DISEASE DURATION; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG INTOXICATION; EMERGENCY WARD; ESCHERICHIA COLI; FEMALE; GLASGOW COMA SCALE; HEMODIALYSIS; HUMAN; INTENSIVE CARE UNIT; ISCHEMIC HEART DISEASE; MALAISE; MYOCLONUS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT MONITORING; PRIORITY JOURNAL; THROMBOCYTE COUNT; TREATMENT OUTCOME; TREMOR; URINARY TRACT INFECTION;

AGED; ANTIMANIC AGENTS; BIPOLAR DISORDER; FEMALE; HUMANS; NALOXONE; NARCOTIC ANTAGONISTS; POISONING; VALPROIC ACID;

EID: 34548297396     PISSN: 14720205     EISSN: None     Source Type: Journal    
DOI: 10.1136/emj.2007.049791     Document Type: Article

References (4)

1. Spiller HA, Krenzelok EP, Klein-Schwartz W. Multicenter case series of valproic acid ingestion: serum concentrations and toxicity. J Toxicol clin Toxicol 2000;38:755-60.
2. Hicks LK, McFarlane PA. Valproic acid overdose and haemodialysis. Nephrol Dial Transplant 2001;16:1483-6.
3. Dingledine R, Iverson LL, Breuker E. Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies. Eur J Pharmacol 1978;47:19-27.
4. Hyden H, Cupello A, Palm A. Naloxone reverses the inhibition by sodium valproate of GABA transport across the Deiter's neuronal plasma membrane. Ann Neurol 1987;21:416-7.