Organelle-specific targeting in drug delivery and design

Advanced Drug Delivery Reviews

Volumn 59, Issue 8, 2007, Pages 697-

  Lim, Carol S ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN;

CELL NUCLEUS; CELL ORGANELLE; CHRONIC MYELOID LEUKEMIA; CYTOSOL; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG TARGETING; EDITORIAL; ENDOPLASMIC RETICULUM; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING;

EID: 34548294740     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2007.06.001     Document Type: Editorial

References (6)

1. Blobel G., and Dobberstein B. Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J. Cell. Biol. l67 (1975) 835-851
2. Heemels M.T. Medicine Nobel goes to pioneer of protein guidance mechanisms. Nature 401 (1999) 625
3. Davis J.R., Kakar M., and Lim C.S. Controlling protein compartmentalization to overcome disease. Pharm. Res. 24 (2007) 17-27
4. Jans D.A., Chan C.K., and Huebner S. Signals mediating nuclear targeting and their regulation: application in drug delivery. Med. Res. Rev. 18 (1998) 189-223
5. Kanwal C., Mu S., Kern S.E., and Lim C.S. Bidirectional on/off switch for controlled targeting of proteins to subcellular compartments. J. Control. Release 98 (2004) 379-393
6. M. Kakar, J.R. Davis, C.S. Lim, Optimizing the protein switch: altering nuclear import and export signals, and ligand binding domain. J. Control. Release (in press).