Sildenafil may facilitate weaning in mechanically ventilated COPD patients: A report of three cases

Anaesthesia and Intensive Care

Volumn 35, Issue 4, 2007, Pages 610-613

  Stanopoulos, I ^a   Manolakoglou, N ^a   Pitsiou, G ^a   Trigonis, I ^a   Tsiata, E A ^a   Boutou, A K ^a,b   Kontou, P K ^a   Argyropoulou, P ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b NONE   (Greece)

Author keywords

COPD; Mechanical ventilation; Sildenafil

Indexed keywords

ANTIBIOTIC AGENT; BRONCHODILATING AGENT; FUROSEMIDE; OXYGEN; SILDENAFIL;

ADULT; AGED; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE EXACERBATION; EMPHYSEMA; ENDOTRACHEAL TUBE; HEART OUTPUT; HEMODYNAMICS; HUMAN; HYPERCAPNIA; LUNG ARTERY PRESSURE; MALE; NASOGASTRIC TUBE; OXYGEN THERAPY; PULMONARY ARTERY CATHETER; RESPIRATORY FAILURE; TIDAL VOLUME; VENTILATED PATIENT;

EID: 34548294705     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0703500425     Document Type: Article

References (18)

1. Lemaire F. Difficult weaning. Intensive Care Med 1993; 19: S69-S73.
2. Vallverdu I, Calaf N, Subirana M, Net A, Benito S, Mancebo J. Clinical characteristics, respiratory functional parameters, and outcome of a two-hour T-piece trial in patients weaning from mechanical ventilation. Am J Respir Crit Care Med 1998; 158:1855-1862.
3. Jubran A, Tobin M. Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation. Am J Respir Crit Care Med 1997; 155:906-915.
4. Pinsky MR. Cardiovascular issues in respiratory care. Chest 2005; 128:592S-597S.
5. Lemaire F, Teboul JL, Cinotti L, Giotto G, Abrouk F, Steg G et al. Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology 1988; 69:171-179.
6. Richard C, Teboul JL, Archambaud F, Hebert JL, Michaut P, Auzepy P. Left ventricular function during weaning of patients with chronic obstructive pulmonary disease. Intensive Care Med 1994; 20:181-186.
7. Jubran A, Mathru M, Dries D, Tobin M. Continuous recordings of mixed venous oxygen saturation during weaning from mechanical ventilation and the ramifications thereof. Am J Respir Crit Care Med 1998; 158:1763-1769.
8. Chatila W, Ani S, Guaglianone D, Jacob B, Amoateng-Adjepong Y, Manthous CA. Cardiac ischemia during weaning from mechanical ventilation. Chest 1996; 109:1421-1422.
9. Galie N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005; 353:2148-2157.
10. Stanopoulos I, Hatzichristou D, Tryfon S, Tzortzis V, Apostolidis A, Argyropoulou P. Effects of sildenafil on cardiopulmonary responses during stress. J Urol 2003; 169:1417-1421.
11. Ghofrani HA, Wiedermann R, Rose F, Schermuly RT, Olschewski H, Weissmann N et al. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 2002; 360:895-900.
12. Ng J, Finney SJ, Shulman R, Bellingan GJ, Singer M, Glyme PA. Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil? Br J Anaesth 2005; 94:774-777.
13. Giacomini M, Borotto E, Bosotti L, Denkewitz T, Reali-Forster C, Carlucci P et al. Vardenafil and weaning from inhaled nitric oxide: effect on pulmonary hypertension in ARDS. Anaesth Intensive Care 2007; 35:91-93.
14. Alp S, Skrygan M, Schmidt WE, Bastian A. Sildenafil improves hemodynamic parameters in COPD - an investigation of six patients. Pulm Pharmacol Ther 2006; 19:386-390.
15. Vassilakopoulos T, Routsi C, Sotiropoulou C, Bitsakou C, Stanopoulos I, Roussos C et al. The combination of the load/force balance and the frequency/tidal volume can predict weaning outcome. Intensive Care Med 2006; 32:684-691.
16. 2 difference and dead space/tidal volume ratio in respiratory failure. Chest 1987; 92:832.
17. Charan NB. Does sildenafil also improve breathing? Chest 2001; 120:305-306.
18. Guazzi M, Tumminello G, Di Marco F, Fiorentini C, Guazzi MD. The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure. J Am Coll Cardiol 2004; 44:2339-2348.