Treatment of naturally acquired common colds with zinc: A structured review

Clinical Infectious Diseases

Volumn 45, Issue 5, 2007, Pages 569-574

  Caruso, Thomas J ^a   Prober, Charles G ^a   Gwaltney Jr , Jack M ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOSE SPRAY; PLACEBO; ZINC;

ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; DATA BASE; DISEASE DURATION; DRUG EFFICACY; DRUG FORMULATION; EXPERIMENTAL STUDY; HUMAN; LOZENGE; MEDICAL LITERATURE; MEDICAL RESEARCH; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL;

ANTIVIRAL AGENTS; COMMON COLD; DOUBLE-BLIND METHOD; HUMANS; RANDOMIZED CONTROLLED TRIALS; ZINC;

EID: 34548279282     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/520031     Document Type: Article

References (47)

1. Gwaltney JM Jr, Hendley JO, Simon G, Jordan WS Jr. Rhinovirus infections in an industrial population. I. The occurrence of illness. N Engl J Med 1966; 275:1261-8.
2. Pitkaranta A, Hayden FG. Rhinoviruses: important respiratory pathogens. Ann Med 1998; 30:529-37.
3. Gwaltney JM. Viral respiratory infection therapy: historical perspectives and current trials. Am J Med 2002; 112(Suppl 6A):33S-41S.
4. Couch RB. The common cold: control? J Infect Dis 1984; 150:167-73.
5. Gaur AH, Hare ME, Shorr RI. Provider and practice characteristics associated with antibiotic use in children with presumed viral respiratory tract infections. Pediatrics 2005; 115:635-41.
6. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984; 25:20-4.
7. Novick SG, Godfrey JC, Godfrey NJ, Wilder HR. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action. Med Hypotheses 1996; 46:295-302.
8. Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol 1976; 18:298-306.
9. Geist FC, Bateman JA, Hayden FG. In vitro activity of zinc salts against human rhinoviruses. Antimicrob Agents Chemother 1987; 31:622-4.
10. Gadomski A. A cure for the common cold? Zinc again. JAMA 1998; 279:1999-2000.
11. Alexander TH, Davidson TM. Intranasal zinc and anosmia: the zinc-induced anosmia syndrome. Laryngoscope 2006; 116:217-20.
12. Jafek BW, Linschoten MR, Murrow BW. Anosmia after intranasal zinc gluconate use. Am J Rhinol 2004; 18:137-41.
13. Farr BM, Conner EM, Betts RF, Oleske J, Minnefor A, Gwaltney JM Jr. Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds. Antimicrob Agents Chemother 1987; 31:1183-7.
14. Douglas RM, Miles HB, Moore BW, Ryan P, Pinnock CB. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987; 31:1263-5.
15. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989; 33:646-8.
16. Garland ML, Hagmeyer KO. The role of zinc lozenges in treatment of the common cold. Ann Pharmacother 1998; 32:63-9.
17. Hulisz D. Efficacy of zinc against common cold viruses: an overview. J Am Pharm Assoc 2004; 44:594-603.
18. Marshall S. Zinc gluconate and the common cold: review of randomized controlled trials. Can Fam Physician 1998; 44:1037-42.
19. Jackson JL, Lesho E, Peterson C. Zinc and the common cold: a meta-analysis revisited. J Nutr 2000; 130(5S Suppl):1512S-5S.
20. Jackson JL, Peterson C, Lesho E. A meta-analysis of zinc salts lozenges and the common cold. Arch Intern Med 1997; 157:2373-6.
21. Caruso TJ, Gwaltney JM Jr. Treatment of the common cold with echinacea: a structured review. Clin Infect Dis 2005; 40:807-10.
22. Higgins JPT, Green S, eds. Incorporating assessments of study validity in reviews. Section 6.10. In: The Cochrane handbook for systematic reviews of interventions 4.2.5. Updated May 2005. Available at: http://www.cochrane. org/resources/handbook/. Accessed 15 January 2007.
23. Macknin ML, Piedmonte M, Calendine C, Janosky J, Wald E. Zinc gluconate lozenges for treating the common cold in children: a randomized controlled trial. JAMA 1998; 279:1962-7.
24. Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Am J Med 2001; 111:103-8.
25. Turner RB, Cetnarowski WE. Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds. Clin Infect Dis 2000; 31:1202-8.
26. Weismann K, Jakobsen JP, Weismann JE, et al. Zinc gluconate lozenges for common cold: a double-blind clinical trial. Dan Med Bull 1990; 37:279-81.
27. Eby GA, Halcomb WW. Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006; 12:34-8.
28. Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM 2003; 96:35-43.
29. Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 2000; 133:245-52.
30. Mossad SB, Macknin ML, Medendorp SV, Mason P. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125:81-8.
31. Petrus EJ, Lawson KA, Bucci LR, Blum K. Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Curr Ther Res 1998; 59:595-607.
32. Godfrey JC, Conant Sloane B, Smith DS, Turco JH, Mercer N, Godfrey NJ. Zinc gluconate and the common cold: a controlled clinical study. J Int Med Res 1992; 20:234-46.
33. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: a double-blind, placebo-controlled trial. Ear Nose Throat J 2000; 79:778-80, 82.
34. Moher D, Jadad AR, Nichol G, Penman M, Tugwell P, Walsh S. Assessing the quality of randomized controlled trials: an annotated bibliography of scales and checklists. Control Clin Trials 1995; 16:62-73.
35. Moher D, Jadad AR, Tugwell P. Assessing the quality of randomized controlled trials: current issues and future directions. Int J Technol Assess Health Care 1996; 12:195-208.
36. Higgins JPT, Green S, eds. Approaches to summarizing the validity of studies. Section 6.7. In: The Cochrane handbook for systematic reviews of interventions 4.2.5. Updated May 2005. Available at: http://www.cochrane. org/resources/handbook/. Accessed 15 January 2007.
37. Emerson JD, Burdick E, Hoaglin DC, Mosteller F, Chalmers TC. An empirical study of the possible relation of treatment differences to quality scores in controlled randomized clinical trials. Control Clin Trials 1990; 11:339-52.
38. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995; 273:408-12.
39. Juni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. JAMA 1999; 282:1054-60.
40. Farr BM, Gwaltney JM Jr. The problems of taste in placebo matching: an evaluation of zinc gluconate for the common cold. J Chronic Dis 1987; 40:875-9.
41. Higgins JPT, Green S, eds. Intention to treat issues. Section 8.4. In: The Cochrane handbook for systematic reviews of interventions 4.2.5. Updated May 2005. Available at: http://www.cochrane.org/resources/handbook/. Accessed 15 January 2007.
42. Diehl HS. Medicinal treatment of the common cold. JAMA 1933; 101:2042-9.
43. Hayden FG, Diamond L, Wood PB, Korts DC, Wecker MT. Effectiveness and safety of intranasal ipratropium bromide in common colds: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1996; 125:89-97.
44. Chalmers TC. Effects of ascorbic acid on the common cold: an evaluation of the evidence. Am J Med 1975; 58:532-6.
45. Karlowski TR, Chalmers TC, Frenkel LD, Kapikian AZ, Lewis TL, Lynch JM. Ascorbic acid for the common cold: a prophylactic and therapeutic trial. JAMA 1975; 231:1038-42.
46. Turner RB. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Clin Infect Dis 2001; 33:1865-70.
47. Fendrick AM, Monto AS, Nightengale B, Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003; 163:487-94.