Microvascular responses following digital thermal hyperaemia and iontophoresis measured by laser Doppler imaging in idiopathic inflammatory myopathy

Rheumatology

Volumn 46, Issue 9, 2007, Pages 1483-1486

  Gunawardena, H ^a   Harris, N D ^a   Carmichael, C ^a   McHugh, Neil J ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

Author keywords

Endothelial function; Laser Doppler imaging; Microvascular; Myositis

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM; VASOACTIVE AGENT;

ADULT; AGED; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOMYOSITIS; DIGITAL ARTERY; DISEASE DURATION; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; HYPEREMIA; IMAGE ANALYSIS; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MALE; MICROVASCULATURE; POLYMYOSITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VASCULAR ENDOTHELIUM; VASODILATATION;

AGED; DERMATOMYOSITIS; ENDOTHELIUM, VASCULAR; FEMALE; FINGERS; HUMANS; HYPEREMIA; IONTOPHORESIS; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MIDDLE AGED; MYOSITIS; POLYMYOSITIS; VASODILATION;

EID: 34548257354     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kem175     Document Type: Article

References (22)

1. Dalakas MC. Polymyositis and dermatomyositis. Lancet 2003;362:971-82.
2. Kissel JT, Mendell JR, Rammohan KW. Microvascular deposition of complement membrane attack complex in dermatomyositis. N Eng J Med 1988;314:329-34.
3. Emslie-Smith AM, Engel AG. Microvascular changes in early and advanced dermatomyositis: A quantitative study. Ann Neurol 1990;27:343-56.
4. Crowson AN, Magro CM. The role of microvascular injury in the pathogenesis of cutaneous lesions in dermatomyositis. Hum Pathol 1996;27:15-9.
5. Diallakas MC. Mechanisms of disease: Signalling pathways and immunobiology of inflammatory myopathies. Nat Clin Pract Rheumtol 2006;2:219-27.
6. Nagaraju K, Rider LG, Fan C et al. Endothelial call activation and neovascularization are prominent in dermatomyositis. J Autoimmune Dis 2006;3:2.
7. Sallum AM, Kiss MH, Silva CA et al. Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. Autoimmun Rev 2006;5:93-100.
8. D'Cruz D, Keser G, Khamashta MA et al. Antlendothelial cell antibodies in inflammatory myopathies: Distribution among clinical and serologic groups and association with interstitial lung disease. J Rheumatoll 2000;27:161-4.
9. La Civita L, Rossi M, Vagheggini G et al. Microvascular involvement in systemic sclerosis: Laser Doppler evaluation of reactivity to acetylcholine and sodium nitroprusside by iontophoresis. Ann Rheum Dis 1998;57:52-5.
10. Anderson ME, Moore TL, Lunt M, Herrick AL. Digital iontophotesis of vasoactive substances as measured by laser Doppler imaging-a non-Invasive technique by which to meapure microvescular dysfunction in Raynaud's phenomenon. Rheumalology 2004;43:986-91.
11. Gunawardena H, Harris ND, Carmichael C, McHugh NJ. Maxinium blood flow and microvascular regulatory responses in systemic sclerosis. Rheumatolqgy 2007 May 9, [Epub ahead of print).
12. Bohan A, Peter JB. Polymyositis and dermatomyositis (parts 1 and 2). N Engf J Med 1975;292:344-7. 403-7.
13. Betteridge Z, North J, Gunawardena H, Slinn J, McHugh N. Identification of Novel Autoantibodies to SUMO-1 E1 In Dermatomyositis (abstract), Arthritis Rheum 2006;54(Suppi 9):S660.
14. Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 2001;91:1619-26.
15. Boignard A, Salvat-Mells M, Carpentier PH et al. Local hyperaemia to heating is impaired in secondary Raynaud's phenomenon. Arthritis Res Ther 2005;7:1103-12.
16. Kubli S, Waeber B, Dalle-Ave A, Feihl F. Reproducibility of laser Doppler imaging of skin blood flow as a tool to assess andothelial function. J Cardiovasc Pharmacol 2000;36:640-8.
17. Harris ND, Hiscock S, Elvins DM, McHugh NJ. Maximum hyperaemic response as a biological reference for Laser Doppler blood flow measurements (abstract). Microcirculation 2004;11(Suppl)S527.
18. Rajagopalan S, Pfenninger D, Kehrer C et al. Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: Implications for vascular dysfunction and progression of disease. Arthritis Rheum 2003;48:1992-2000.
19. Hansell J, Henareh L, Agewall S, Norman M. Non-invassive assessment of endothelial function - relation between vasodilatory responses in skin microcirculation and brachial artery. Clin Physiol Funct Imaging 2004;24:317-22.
20. Clark S, Dunn G, Moore T, Jayson M, King TA, Herrick AL. Comparison of thermography and laser Doppler imaging in the assessment of Raynaud's phenomenon, Microvasc Res 2003;66:73-6.
21. Anderson ME, Moore TL, Lunt M, Herrick AL, The 'distal-dorsal difference': A thermographic parameter by which to differentiate between primary and secondary Raynaud's phenomenon. Rheumatology 2007;46:533-8.
22. Datta D, Ferrel WR, Sturrock RD, Jadhav ST, Sattar N, Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis. Atherosclerosis 2006 Jun 22, [Epub ahead of print].