HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: The spectrum of HHV-8+ lymphoproliferative disorders expands

American Journal of Surgical Pathology

Volumn 31, Issue 9, 2007, Pages 1439-1445

  Seliem, Rania M ^a,b   Griffith, Rogers C ^d   Harris, Nancy L ^a,b   Beheshti, Javad ^d   Schiffman, Fred J ^d   Longtine, Janina ^b,c   Kutok, Jeffery ^b,c   Ferry, Judith A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MIRIAM HOSPITAL   (United States)

Author keywords

Germinotropic; HIV; Human herpesvirus 8 (HHV 8); Kaposi sarcomaassociated herpes virus (KSHV); Lymphoma; Multicentric Castleman disease

Indexed keywords

CD20 ANTIBODY; SYNDECAN 1;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; EPSTEIN BARR VIRUS; ERYTHROPHAGOCYTOSIS; HISTOPATHOLOGY; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; IMMUNOBLAST; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MALE; PARAAORTIC LYMPH NODE; SPLENOMEGALY;

ANTIGENS, CD20; BONE MARROW CELLS; CELL PROLIFERATION; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; FATAL OUTCOME; GIANT LYMPH NODE HYPERPLASIA; HERPESVIRUS 4, HUMAN; HERPESVIRUS 8, HUMAN; HIV SEROPOSITIVITY; HUMANS; INTERFERON REGULATORY FACTORS; KI-67 ANTIGEN; LYMPH NODES; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; RECEPTORS, COMPLEMENT 3D; SPLENOMEGALY; SYNDECAN-1;

EID: 34548237869     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31804d43d8     Document Type: Article

References (23)

1. Cesarman E, Chang Y, Moore PS, et al. Kaposi's sarcoma-associated herpes virus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995;332:1186-1191.
2. Cesarman E, Knowles D. Kaposi's sarcoma-associated herpesvirus: a lymphotropic human herpesvirus associated with Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. Sem Diagn Pathol. 1997;14:54-66.
3. Chadburn A, Hyjek E, Mathew S, et al. KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol. 2004;28:1401-1416.
4. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpes virus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266:1865-1869.
5. Coupland SE, Charlotte F, Mansour G, et al. HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man. Am J Surg Pathol. 2005;29:647-652.
6. Dong HY, Scadden DT, de Leval L, et al. Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. Am J Surg Pathol. 2005;29:1633-1641.
7. Donovan J, Ladetto M, Zou G, et al. Immunoglobulin heavy-chain consensus probes for real-time PCR quantification of residual disease in acute lymphoblastic leukemia. Blood. 2000;95:2651-2658.
8. Du M-Q, Liu H, Diss T, et al. Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood. 2001;97:2130-2136.
9. Du M-Q, Diss T, Liu H, et al. KSHV- and EBV-associated germinotropic lymphoproliferative disorder. Blood. 2002;100:3415-3418.
10. Dupin N, Diss T, Kellam P, et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood. 2000;95:1406-1412.
11. Filipovich A. Hemophagocytic lymphohistiocytosis and related disorders. Curr Opin Allergy Clin Immunol. 2006;6:410-415.
12. Hamoudi R, Diss TC, Oksenhendler E, et al. Distinct cellular origins of primary effusion lymphoma with and without EBV infection. Leukemia Res. 2004;28:333-338.
13. Henke-Gendo C, Schulz TF, Du MQ. Transmission and disease association of Kaposi's sarcoma-associated herpesvirus: recent developments KSHV- and EBV-associated germinotropic lymphoproliferative disorder. Curr Opin Infect Dis. 2004;17:53-57.
14. Herrada J, Cabanillas F, Rice L, et al. The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med. 1998;128:657-662.
15. Jaffe ES. Primary body cavity-based AIDS-related lymphomas. Evolution of a new disease entity. Am J Clin Pathol. 1996;105:141-143.
16. Jaffe E, Harris N, Stein H, et al. Tumours of the Haematopoietic and Lymphoid Tissues. 1st ed. Lyon: IARC Press; 2001:351.
17. Janka G, Imashuku S, Elinder G, et al. Infection and malignancy- associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am. 1998;12:435-444.
18. Li CF, Ye H, Liu H, et al. Fatal HHV-8-associated hemophagocytic syndrome in an HIV-negative immunocompetent patient with plasmablastic variant of multicentric Castleman disease (plasmablastic microlymphoma). Am J Surg Pathol. 2006;30:123-127.
19. Low P, Neipel F, Rascu A, et al. Suppression of HHV-8 viremia by foscarnet in an HIV-infected patient with Kaposi's sarcoma and HHV-8 associated hemophagocytic syndrome. Eur J Med Res. 1998;3:461-464.
20. Nador R, Cesarman E, Chadburn A, et al. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood. 1996;88:645-656.
21. Oksenhendler E, Boulanger E, Galicier L, et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphomas in patients with HIV infection and multicentric Castleman's disease. Blood. 2002;99:2331-2336.
22. Soulier J, Grollet L, Oksenhendler E, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995;84:1276-1280.
23. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.