Dissociation between objective psychomotor impairment and subjective sleepiness after diazepam administration in the aged people

Human Psychopharmacology

Volumn 22, Issue 6, 2007, Pages 365-372

  Echizenya, Masaru ^a   Mishima, Kazuo ^b   Satoh, Kohtoku ^a   Kusanagi, Hiroaki ^a   Ohkubo, Tadashi ^c   Shimizu, Tetsuo ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^c Research Institute of Shichifuku Pharmacy   (Japan)

Author keywords

Aging; Benzodiazepine; Diazepam; Dissociation; Psychomotor function; Sleepiness

Indexed keywords

BENZODIAZEPINE; DIAZEPAM;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BRAIN FUNCTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; PSYCHOMOTOR DISORDER; RANDOMIZED CONTROLLED TRIAL; RESPONSE TIME; SCORING SYSTEM; SIDE EFFECT; SINGLE BLIND PROCEDURE; SOMNOLENCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADOLESCENT; ADULT; AGED; AGING; ANALYSIS OF VARIANCE; ATTENTION; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CROSS-OVER STUDIES; DIAZEPAM; HUMANS; MALE; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE; SINGLE-BLIND METHOD; SLEEP;

EID: 34548229366     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.859     Document Type: Article

References (32)

1. Baranski JV, Pigeau RA, Angus RG. 1994. On the ability to self-monitor cognitive performance during sleep deprivation: a calibration study. J Sleep Res 3: 36-44.
2. Barbanoj MJ, Garcia-Gea C, Antonijoan R, et al. 2006. Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol in healthy volunteers. Hum Psychopharmacol 21: 13-26.
3. Barbone F, McMahon AD, Davey PG, et al. 1998. Association of road-traffic accidents with benzodiazepine use. Lancet 352: 1331-1336.
4. Barbui C, Gregis M, Zappa M. 1998. A cross-sectional audit of benzodiazepine use among general practice patients. Acta Psychiatr Scand 97: 153-156.
5. Bertz RJ, Kroboth PD, Kroboth FJ, et al. 1997. Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects. J Pharmacol Exp Ther 281: 1317-1329.
6. Campbell SS, Dawson D. 1990. Enhancement of night time alertness and performance with bright ambient light. Physiol Behav 48: 317-320.
7. Cole RJ, Kripke DF, Gruen W, Mullaney DJ, Gillin JC. 1992. Automatic sleep/wake identification from wrist activity. Sleep 15: 461-469.
8. Dorrian J, Lamond N, Dawson D. 2000. The ability to self-monitor performance when fatigued. J Sleep Res 9: 137-144.
9. Gillberg M, Kecklund G, Akerstedt T. 1994. Relations between performance and subjective ratings of sleepiness during a night awake. Sleep 17: 236-241.
10. Greenblatt DJ, Harmatz JS, Shader RI. 1991a. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I). Clin Pharmacokinet 21: 165-177.
11. Greenblatt DJ, Harmatz JS, Shader RI. 1991b. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II). Clin Pharmacokinet 21: 262-273.
12. Greenblatt DJ, Harmatz JS, Shapiro L, Engelhardt N, Gouthro TA, Shader RI. 1991c. Sensitivity to triazolam in the elderly. N Engl J Med 324: 1691-1698.
13. Hemmelgarn B, Suissa S, Huang A, Boivin JF, Pinard G. 1997. Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA 278: 27-31.
14. Herings RM, Stricker BH, de Boer A, Bakker A, Sturmans F. 1995. Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. Arch Intern Med 155: 1801-1807.
15. Hinrichs JV, Ghoneim MM. 1987. Diazepam, behavior, and aging: increased sensitivity or lower baseline performance? Psychopharmacology (Bed) 92: 100-105.
16. Hoddes E, Zarcone V, Smythe H, Phillips R, Dement WC. 1973. Quantification of sleepiness: a new approach. Psychophysiology 10: 431-436.
17. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Harmatz JS, Shader RI. 1998. Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects. J Clin Pharmacol 38: 14-21.
18. Koelega HS. 1989. Bonzodiazepines and vigilance performance: a review. Psychopharmacology (Berl) 98: 145-156.
19. Magrini N, Vaccheri A, Parma E, et al. 1996. Use of benzodiazepines in the Italian general population: prevalence, pattern of use and risk factors for use. Eur J Clin Pharmacol 50: 19-25.
20. Matsumoto Y, Mishima K, Satoh K, Shimizu T, Hishikawa Y. 2002. Physical activity increases the dissociation between subjective sleepiness and objective performance levels during extended wakefulness in human. Neurosci Lett 326: 133-136.
21. Mills JN, Minors DS, Waterhouse JM. 1978. Adaptation to abrupt time shifts of the oscillator(s) controlling human circadian rhythms. J Physiol 285: 455-470.
22. Miura M, Ohkubo T, Sugawara K, Okuyama N, Otani K. 2002. Determination of estazolam in plasma by high-performance liquid chromatography with solid-phase extraction. Anal Sci 18: 525-528.
23. Morgan K. 1990. Hypnotics in the elderly. What cause for concern? Drugs 40: 688-696.
24. Nagasaki T, Ohkubo T, Sugawara K, Yasui N, Furukori H, Kaneko S. 1999. Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography: application to therapeutic drug monitoring in Japanese patients with schizophrenia. J Pharm Biomed Anal 19: 595-601.
25. Platten HP, Schweizer E, Dilger K, Mikus G, Kiotz U. 1998. Pharmacokinetics and the pharmacodynamic action of midazolain in young and elderly patients undergoing tooth extraction. Clin Pharmacol Ther 63: 552-560.
26. Ray WA, Thapa PB, Gideon P. 2000. Benzodiazepines and the risk of falls in nursing home residents. J Am Geriatr Soc 48: 682-685.
27. Sekine A, Niiyama Y, Kutsuzawa O, Shimizu T. 2001. A negative component superimposed on event-related potentials during light drowsiness. Psychiatry Clin Neurosci 55: 473-478.
28. Sheehan DV, Lecrubier Y, Sheehan KH, et al. 1998. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59: 22-33.
29. Verster JC, Veldhuijzen DS, Volkerts ER. 2004. Residual effects of sleep medication on driving ability. Sleep Med Rev 8: 309-325.
30. Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J. 2001. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry 158: 892-898.
31. Woods JH, Katz JL, Winger G. 1987. Abuse liability of benzodiazepines. Pharmacol Rev 39: 251-413.
32. Woods JH, Katz JL, Winger G. 1992. Benzodiazepines: use, abuse, and consequences. Pharmacol Rev 44: 151-347.