Urinary purine derivates excretion as an indicator of in vivo microbial N flow in cattle: A review

Livestock Science

Volumn 111, Issue 3, 2007, Pages 181-192

  Tas, B M ^a   Susenbeth, A ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Allantoin; Cattle; Microbial N; Purine base; Purine derivative excretion

Indexed keywords

ANIMALIA; BOS;

EID: 34548220445     PISSN: 18711413     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.livsci.2007.05.010     Document Type: Review

References (93)

1. Allen M.S. Relationship between fermentation acid production in the rumen and the requirement for physically effective fiber. J. Dairy Sci. 80 (1997) 1447-1452
2. Al-Khalidi U.A.S., and Chaglassian T.H. The species distribution of xanthine oxidase. Biochem. J. 97 (1965) 318-320
3. Antoniewicz A.M., Heinemann W.W., and Hanks E.M. The effect of changes in the intestinal flow of nucleic acids on the allantoin excretion in the urine of sheep. J. Agric. Sci. Camb. 95 (1980) 395-400
4. Bach A., Calsamiglia S., and Stern M.D. Nitrogen metabolism in the rumen. J. Dairy Sci. 88 (2005) E9-E21
5. Balcells J., Guada J.A., Castrillo C., and Gasa J. Urinary excretion of allantoin and allantoin precursors by sheep after different rates of purine infusion into the duodenum. J. Agric. Sci. 116 (1991) 309-317
6. Balcells J., Guada J.A., Peiro J.M., and Parker D.S. Simultaneous determination of allantoin and oxypurines in biological-fluids by high-performance liquid-chromatography. J. Chromatogr., B, Biomed. Sci. Appl. 575 (1992) 153-157
7. Balcells J., Guada J.A., Castrillo C., and Gasa J. Rumen digestion and urinary excretion of purine derivatives in response to urea supplementation of sodium-treated straw fed to sheep. Br. J. Nutr. 69 (1993) 721-732
8. Balcells J., Seal C.J., and Parker D.S. Effect of intravenous glucose-infusion on metabolism of portal-drained viscera in sheep fed a cereal straw-based diet. J. Anim. Sci. 73 (1995) 2146-2155
9. Bannink A., Valk H., and van Vuuren A.M. Intake and excretion of sodium, potassium, and nitrogen and the effects on urine production by lactating dairy cows. J. Dairy Sci. 82 (1999) 1008-1018
10. Bannink A., Kogut J., Dijkstra J., France J., Kebreab E., Van Vuuren A.M., and Tamminga S. Estimation of the stoichiometry of volatile fatty acid production in the rumen of lactating cows. J. Theor. Biol. 238 (2006) 36-51
11. Beckers Y., and Thewis A. Excretion of purine derivatives in urine of Belgian Blue bulls following duodenal infusion of purines from Torula yeast. Proc. Soc. Nutr. Physiol. 235 (1994)
12. Broderick G.A., and Merchen N.R. Markers for quantifying microbial protein synthesis in the rumen. J. Dairy Sci. 75 (1992) 2618-2632
13. Calsamiglia S., Stern M.D., and Firkins J.L. Comparison of nitrogen-15 and purines as microbial markers in continuous culture. J. Anim. Sci. 74 (1996) 1375-1381
14. 15N and purine bases) and bacterial isolated for the estimation of rumen microbial protein synthesis. Anim. Sci. 75 (2002) 315-321
15. Chen X.B., Hovell F.D.D., and Ørskov E.R. Excretion of purine derivatives by ruminants - recycling of allantoin into the rumen via saliva and its fate in the gut. Br. J. Nutr. 63 (1990) 197-205
16. Chen X.B., Ørskov E.R., and Hovell F.D.D. Excretion of purine derivatives by ruminants - endogenous excretion, differences between cattle and sheep. Br. J. Nutr. 63 (1990) 121-129
17. Chen X.B., Hovell F.D.D., Ørskov E.R., and Brown D.S. Excretion of purine derivatives by ruminants - effect of exogenous nucleic-acid supply on purine derivative excretion by sheep. Br. J. Nutr. 63 (1990) 131-142
18. Chen X.B., Chen Y.K., Franklin M.F., Ørskov E.R., and Shand W.J. The effect of feed intake and body weight on purine derivative excretion and microbial protein supply in sheep. J. Anim. Sci. 70 (1992) 1534-1542
19. Chen X.B., Chowdhury S.A., Hovell F.D.D., Ørskov E.R., and Kyle D.J. Endogenous allantoin excretion in response to changes in protein supply in sheep. J. Nutr. 122 (1992) 2226-2232
20. Chen X.B., Grubic G., Ørskov E.R., and Osuji P. Effect of feeding frequency on diurnal-variation in plasma and urinary purine derivatives in steers. Anim. Prod. 55 (1992) 185-191
21. Chen X.B., Kyle D.J., and Ørskov E.R. Measurement of allantoin in urine and plasma by high-performance liquid-chromatography with precolumn derivatization. J. Chromatogr., B, Biomed. Sci. Appl. 617 (1993) 241-247
22. Chen X.B., Mejia A.T., Kyle D.J., and Ørskov E.R. Evaluation of the use of the purine derivative-creatinine ratio in spot urine and plasma samples as an index of microbial protein supply in ruminants - studies in sheep. J. Agric. Sci. 125 (1995) 137-143
23. Chen X.B., Fujihara T., Nakamura K., Mawuenyegah P.O., Franklin M.F., and Kyle D.J. Response of urinary and plasma purine derivatives to various rates and infusion patterns of purines in sheep nourished by intragastric infusion. J. Agric. Sci. 129 (1997) 343-352
24. Dapoza C., Castrillo C., Balcells J., Martín-Orúe S., and Guada J.A. On the variation of urinary excretion of creatinine and purine derivatives in pregnant and lactating ewes given diets with different protein contents. Anim. Sci. 68 (1999) 555-566
25. Dewhurst R.J., Mitton A.M., Offer N.W., and Thomas C. Effects of the composition of grass silages on milk production and nitrogen utilization by dairy cows. Anim. Sci. 62 (1996) 25-34
26. Dijkstra J. Production and absorption of volatile fatty acids in the rumen. Livest. Prod. Sci. 39 (1994) 61-69
27. Djouvinov D.S., Nakashima Y., Todorov N., and Pavlov D. In situ degradation of feed purines. Anim. Feed Sci. Technol. 71 (1998) 67-77
28. Faichney G.J., Welch R.J., and Brown G.H. Prediction of the excretion of allantoin and total purine derivatives by sheep from the 'creatinine coefficients'. J. Agric. Sci. 125 (1995) 425-428
29. Firkins J.L., Hristov A.N., Hall M.B., Varga G.A., and St-Pierre N.R. Integration of ruminal metabolism in dairy cattle. J. Dairy Sci. 89 (2006) E31-E51
30. Fujihara T., Ørskov E.R., Reeds P.J., and Kyle D.J. The effect of protein infusion on urinary excretion of purine derivatives in ruminants nourished by intragastric nutrition. J. Agric. Sci. 109 (1987) 7-12
31. Giesecke D., Balsliemke J., Südekum K.-H., and Stangassinger M. Plasma level, clearance and renal excretion of endogenous and ruminal purines in the bovine. J. Anim. Physiol. Anim. Nutr. 70 (1993) 180-189
32. Giesecke D., Ehrentreich L., Stangassinger M., and Ahrens F. Mammary and renal excretion of purine metabolites in relation to energy intake and milk yield in dairy cows. J. Dairy Sci. 77 (1994) 2376-2381
33. Gonda H.L., and Lindberg J.E. Evaluation of dietary nitrogen utilization in dairy cows based on urea concentrations in blood, urine and milk, and on urinary concentration of purine derivatives. Acta Agric. Scand., A Anim. Sci. 44 (1994) 236-245
34. Gonda H.L., and Lindberg J.E. Effect of diet on milk allantoin and its relationship with urinary allantoin in dairy cows. J. Dairy Sci. 80 (1997) 364-373
35. González-Ronquillo M., Balcells J., Guada J.A., and Vicente F. Purine derivative excretion in dairy cows: endogenous excretion and the effect of exogenous nucleic acid supply. J. Dairy Sci. 86 (2003) 1282-1291
36. González-Ronquillo M., Balcells J., Belenguer A., Castrillo C., and Mota M. A comparison of purine derivatives excretion with conventional methods as indices of microbial yield in dairy cows. J. Dairy Sci. 87 (2004) 2211-2221
37. Hristov A.N., Price W.J., and Shafii B. A meta-analysis examining the relationship among dietary factors, dry matter intake, and milk and milk protein yield in dairy cows. J. Dairy Sci. 87 (2004) 2184-2196
38. Hristov A.N., McAllister T.A., Ouellet D.R., and Broderick G.A. Comparison of purines and nitrogen-15 as microbial flow markers in beef heifers fed barley- or corn-based diets. Can. J. Anim. Sci. 85 (2005) 211-222
39. Jensen C., Weisbjerg M.R., and Hvelplund T. Evaluation of methods for estimating the amino acid supply to the duodenum of microbial, endogenous and undegraded feed protein on maize silage diets fed to dairy cows. Anim. Feed Sci. Technol. 131 (2006) 1-24
40. Johnson L.M., Harrison J.H., and Riley R.E. Estimation of the flow of microbial nitrogen to the duodenum using urinary uric acid or allantoin. J. Dairy Sci. 81 (1998) 2408-2420
41. Jonker J.S., Kohn R.A., and Erdman R.A. Using milk urea nitrogen to predict nitrogen excretion and utilization efficiency in lactating dairy cows. J. Dairy Sci. 81 (1998) 2681-2692
42. Kahn L.P., and Nolan J.V. Kinetics of allantoin metabolism in sheep. Br. J. Nutr. 84 (2000) 629-634
43. Kanjanapruthipong J., and Leng R.A. Purine derivatives excreted in urine as an indicator estimating microbial yield from the rumen: a review, Asian Australasia. J. Anim. Sci. 11 (1998) 209-216
44. Kauffman A.J., and St Pierre N.R. The relationship of milk urea nitrogen to urine nitrogen excretion in Holstein and Jersey cows. J. Dairy Sci. 84 (2001) 2284-2294
45. Kohn R.A., Kalscheur K.F., and Russek-Cohen E. Evaluation of models to estimate urinary nitrogen and expected milk urea nitrogen. J. Dairy Sci. 85 (2002) 227-233
46. Makkar H.P.S., and Becker K. Purine quantification in digests from ruminants by spectrophotometric and HPLC methods. Br. J. Nutr. 81 (1999) 107-112
47. Martín-Orúe S.M., Balcells J., Zakraoui F., and Castrillo C. Quantification and chemical composition of mixed bacteria harvested from solid fractions of rumen digesta: effect of detachment procedure. Anim. Feed Sci. Technol. 71 (1998) 269-282
48. Martín-Orúe S.M., Balcells J., Guada J.A., and Fondevila M. Microbial nitrogen production in growing heifers: direct measurement of duodenal flow of purine bases versus urinary excretion of purine derivatives as estimation procedures. Anim. Feed Sci. Technol. 88 (2000) 171-188
49. McAllan A.B. The degradation of nucleic acids in, and the removal of breakdown products from the small intestines of steers. Br. J. Nutr. 44 (1980) 99-112
50. McAllan A.B. The fate of nucleic acids in ruminants. Proc. Nutr. Soc. 41 (1982) 309-317
51. McAllan A.B., and Smith R.H. Degradation of nucleic acids in the rumen. Br. J. Nutr. 29 (1973) 331-345
52. Moorby J.M., Dewhurst R.J., Evans R.T., and Danelón J.L. Effects of dairy cow diet forage proportion on duodenal nutrient supply and urinary purine derivative excretion. J. Dairy Sci. 89 (2006) 3552-3562
53. Nennich T.D., Harrison J.H., Van Wieringen L.M., St-Pierre N.R., Kincaid R.L., Wattiaux M.A., Davidson D.L., and Block E. Prediction and evaluation of urine and urinary nitrogen and mineral excretion from dairy cattle. J. Dairy Sci. 89 (2006) 353-364
54. Obispo N.E., and Dehority B.A. Feasibility of using total purines as a marker for ruminal bacteria. J. Anim. Sci. 77 (1999) 3084-3095
55. Ojeda A., de Parra O., Balcells J., and Belenguer A. Urinary excretion of purine derivatives in Bos indicus × Bos taurus crossbred cattle. Br. J. Nutr. 93 (2005) 821-828
56. Oldick B.S., Firkins J.L., and St-Pierre N.R. Estimation of microbial nitrogen flow to the duodenum of cattle based on dry matter intake and diet composition. J. Dairy Sci. 82 (1999) 1497-1511
57. Orellana Boero P., Balcells J., Martín-Orúe S.M., Liang J.B., and Guada J.A. Excretion of purine derivatives in cows: endogenous contribution and recovery of exogenous purine bases. Livest. Prod. Sci. 68 (2001) 243-250
58. Perez J.F., Rodriguez C.A., Gonzalez J., Balcells J., and Guada J.A. Contribution of dietary purine bases to duodenal digesta in sheep. In situ studies of purine degradability corrected for microbial contamination. Anim. Feed Sci. Technol. 62 (1996) 251-262
59. Perez J.F., Balcells J., Guada J.A., and Castrillo C. Determination of rumen microbial-nitrogen production in sheep: a comparison of urinary purine excretion with methods using N-15 and purine bases as markers of microbial-nitrogen entering the duodenum. Br. J. Nutr. 75 (1996) 699-709
60. Perez J.F., Balcells J., Guada J.A., and Castrillo C. Contribution of dietary nitrogen and purine bases to the duodenal digesta: comparison of duodenal and polyester-bag measurements. Anim. Sci. 65 (1997) 237-245
61. Perez J.F., Balcells J., Guada J.A., and Castrillo C. Rumen microbial production estimated either from urinary purine derivative excretion or from direct measurements of N-15 and purine bases as microbial markers: effect of protein source and rumen bacteria isolates. Anim. Sci. 65 (1997) 225-236
62. Perez J.F., Balcells J., Cebrian J.A., and Martín-Orúe S.M. Excretion of endogenous and exogenous purine derivatives in sheep: effect of increased concentrate intake. Br. J. Nutr. 79 (1998) 237-240
63. Prasitkusol P., Ørskov E.R., Chen X.B., Hovell F.D.D., and Kyle D.J. Variation between sheep in renal excretion of [C-14]allantoin. Br. J. Nutr. 87 (2002) 561-568
64. Reynal S.M., Broderick G.A., Ahvenjarvi S., and Huhtanen P. Effect of feeding protein supplements of differing degradability on omasal flow of microbial and undegraded protein. J. Dairy Sci. 86 (2003) 1292-1305
65. Reynal S.M., Broderick G.A., and Bearzi C. Comparison of four markers for quantifying microbial protein flow from the rumen of lactating dairy cows. J. Dairy Sci. 88 (2005) 4065-4082
66. Rodriguez C.A., Gonzalez J., Alvir M.R., Repetto J.L., Centeno C., and Lamrani F. Composition of bacteria harvested from the liquid and solid fractions of the rumen of sheep as influenced by feed intake. Br. J. Nutr. 84 (2000) 369-376
67. Rosskopf R., and Giesecke D. Investigations in cows on the influence of energy intake on rumen metabolism by means of allantoin excretion in the milk. J. Vet. Med., Ser. A 39 (1992) 515-524
68. Schager W.M., Harrison J.H., Gaskins C.T., and Davidson D. Factors affecting application of milk allantoin as an estimator of microbial protein flow to the duodenum under commercial conditions. J. Dairy Sci. 86 (2003) 1716-1721
69. +-dependent transport across the brush border membrane in cows. J. Dairy Sci. 84 (2001) 614-619
70. Shingfield K.J., and Offer N.W. Evaluation of milk allantoin excretion as an index of microbial protein supply in lactating dairy cows. Anim. Sci. 67 (1998) 371-385
71. Shingfield K.J., and Offer N.W. Evaluation of the spot urine sampling technique to assess urinary pseudouridine excretion in lactating dairy cows. Agric. Food Sci. Finl. 7 (1998) 345-356
72. St-Pierre N.R. Integrating quantitative findings from multiple studies using mixed model methodology. J. Dairy Sci. 84 (2001) 741-755
73. Stangassinger M., Chen X.B., Lindberg J.E., and Giesecke D. Metabolism of purines in relation to microbial production. In: von Engelhardt W., Leonhard-Marek S., Breves G., and Giesecke D. (Eds). Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction (1995), Enke Verlag, Stuttgart 387-406
74. Stefanon B., Mills C.R., Spanghero M., and Susmel P. An evaluation of purine derivatives as indicators of rumen microbial protein synthesis in dry and lactating cows. VII Symposium on Protein Metabolism and Nutrition, Santarem, Portugal, 24-27 May 1995 (1995) 147-152
75. Stern M.D., Varga G.A., Clark J.H., Firkins J.L., Huber J.T., and Palmquist D.L. Evaluation of chemical and physical properties of feeds that affect protein metabolism in the rumen. J. Dairy Sci. 77 (1994) 2762-2786
76. Storm E., Ørskov E.R., and Brown D.S. Nutritive value of rumen microorganisms in ruminants 3. Digestion of microbial amino-acids and nucleic-acids in and losses of endogenous nitrogen from the small intestine of sheep. Br. J. Nutr. 50 (1983) 479-485
77. Südekum K.-H., Brüsemeister K., Schröder A., and Stangassinger M. Effects of amount of intake and stage of forage maturity on urinary allantoin excretion and estimated microbial crude protein synthesis in the rumen of steers. J. Anim. Physiol. Anim. Nutr. 90 (2006) 136-145
78. Surra J.C., Guada J.A., Balcells J., and Castrillo C. Salivary losses of purine derivatives. Anim. Prod. 56 (1993) 463
79. Surra J.C., Guada J.A., Balcells J., and Castrillo C. Renal and salivary clearance of purine derivatives in sheep. Anim. Sci. 65 (1997) 83-91
80. Susmel P., Stefanon B., Plazzotta E., Spanghero M., and Mills C.R. The effect of energy and protein intake on the excretion of purine derivatives. J. Agric. Sci. 123 (1994) 257-265
81. Susmel P., Spanghero M., Stefanon B., and Mills C.R. Nitrogen balance and partitioning of some nitrogen catabolites in milk and urine of lactating cows. Livest. Prod. Sci. 44 (1995) 207-219
82. Tamminga S., and Chen X.B. Animal based techniques for the estimation of protein value of forages. In: Givens D.I., Owen E., Axford R.F.E., and Omed H.M. (Eds). Forage Evaluation in Ruminant Nutrition (2000), CABI Publishing, Wallingford 215-232
83. Timmermans Jr. S.J., Johnson L.M., Harrison J.H., and Davidson D. Estimation of the flow of microbial nitrogen to the duodenum using milk uric acid or allantoin. J. Dairy Sci. 83 (2000) 1286-1299
84. Timmermans Jr. S.J., Johnson L.M., Harrison J.H., and Davidson D. Estimation of the flow of microbial nitrogen to the duodenum using milk uric acid or allantoin. J. Dairy Sci. 83 (2000) 2387-2390
85. Topps J.H., and Elliot R.C. Relationship between concentrations of ruminal nucleic acids and excretion of purine derivatives by sheep. Nature 205 (1965) 498-499
86. Vagnoni D.B., Broderick G.A., Clayton M.K., and Hatfield R.D. Excretion of purine derivatives by Holstein cows abomasally infused with incremental amounts of purines. J. Dairy Sci. 80 (1997) 1695-1702
87. Valadares R.F.D., Broderick G.A., Valadares S.C., and Clayton M.K. Effect of replacing alfalfa silage with high moisture corn on ruminal protein synthesis estimated from excretion of total purine derivatives. J. Dairy Sci. 82 (1999) 2686-2696
88. Van Soest P.J. Nutritional ecology of the ruminant (1994), Comstock Publishing Associates, Ithaca
89. Verbic J., Chen X.B., Macleod N.A., and Ørskov E.R. Excretion of purine derivatives by ruminants - effect of microbial nucleic acid Infusion on purine derivative excretion by steers. J. Agric. Sci. 114 (1990) 243-248
90. Vicente F., Guada J.A., Surra J., Balcells J., and Castrillo C. Microbial contribution to duodenal purine flow in fattening cattle given concentrate diets, estimated by purine N labelling (N-15) of different microbial fractions. Anim. Sci. 78 (2004) 159-167
91. Volden H., Mydland L.T., and Harstad O.M. Chemical composition of protozoal and bacterial fractions isolated from ruminal contents of dairy cows fed diets differing in nitrogen supplementation. Acta Agric. Scand., A Anim. Sci. 49 (1999) 235-244
92. Zebeli Q., Tafaj M., Steingass H., Metzler B., and Drochner W. Effects of physically effective fiber on digestive processes and milk fat content in early lactating dairy cows fed total mixed rations. J. Dairy Sci. 89 (2006) 651-668
93. Zinn R.A., and Owens F.N. A rapid procedure for purine measurement and its use for estimating net ruminal protein synthesis. Can. J. Anim. Sci. 66 (1986) 157-166